Results 91 to 100 of about 28,420 (218)

Cellular Hallmarks From Volume Electron Microscopy Reveal Developmental Progression of Plasmodium Ookinetes

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Nedal Darif, Marco Rheinnecker, Kolja Hildenbrand, Thanat Chookajorn, Lilian P. Dorner, Jean‐Karim Hériché, Sara Henriksson, Charlotta Funaya, Franziska Hentzschel, Linda Sandblad, Oliver Billker, Yannick Schwab, Friedrich Frischknecht   +12 more
wiley   +1 more source

The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei

International Journal for Parasitology: Drugs and Drug Resistance
Background: Studying and discovering the molecular mechanism of Plasmodium sexual development is crucial for the development of transmission blocking drugs and malaria eradication.
Xitong Jia, Yong Wang, Meilian Wang, Hui Min, Zehou Fang, Haifeng Lu, Jiao Li, Yaming Cao, Lunhao Bai, Jinghan Lu   +9 more
doaj   +1 more source

Hepcidin and Host Defense against Infectious Diseases. [PDF]

, 2015
Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Ganz, Tomas, Mehrad, Borna, Michels, Kathryn, Nemeth, Elizabeta   +3 more
core   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Host–parasite oxidative arms race: who will win?

Journal of Avian Biology, Volume 2026, Issue 1, January 2026.
Avian haemosporidian parasites are globally widespread with a broad repertoire of hosts. When infected, the host can either reduce (resistance) and/or limit the severity of parasitaemia (tolerance). Oxidative stress plays a pivotal role in the host's resistance and tolerance, as well as its detrimental endpoints.
Caroline Isaksson, Vaidas Palinauskas, Amparo Herrera Duenas, Olof Hellgren   +3 more
wiley   +1 more source

Sex in Immune Cells and Parasitic Diseases — A Complex Relationship

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Epidemiological studies consistently show that many parasitic diseases affect males more frequently than females. These disparities are multifactorial, arising partly from gender‐specific behaviors that influence exposure risk and health‐seeking practices, especially in low‐ and middle‐income countries. Increasing evidence also highlights that
Barbara Honecker, Charlotte Sophie Hansen, Hanna Lotter   +2 more
wiley   +1 more source

Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events [PDF]

, 2009
Background Plasmodium sporozoites migrate to the liver where they traverse several hepatocytes before invading the one inside which they will develop and multiply into thousands of merozoites.
Prudêncio Miguel, Kappe Stefan HI, Peng Xinxia, Tarun Alice S, Grosso Ana, Carret Céline, Albuquerque Sónia S, Mota Maria M   +7 more
core   +1 more source

Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65)

Journal of Parasitology Research, 2014
The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract of Anthocleista vogelii at different doses in albino mice infected with Plasmodium berghei berghei (NK 65).
Lebari Barine Gboeloh, Okpok Eta Okon, Samuel Effiong Udoh   +2 more
doaj   +1 more source

ELISPOT assay to measure antigen-specific murine CD8(+) T cell responses.

, 2001
The enzyme-linked immunospot technique (ELISPOT) relies on the visualization of cytokine secretion by individual T cells following in vitro stimulation with antigen. This assay has been developed and standardized for the quantitative detection of antigen-
Carvalho, LH, Hafalla, JC, Zavala, F
core   +1 more source

BamView: visualizing and interpretation of next-generation sequencing read alignments. [PDF]

, 2012
So-called next-generation sequencing (NGS) has provided the ability to sequence on a massive scale at low cost, enabling biologists to perform powerful experiments and gain insight into biological processes.
Berriman, Matthew, Carver, Tim, Harris, Simon R., McQuillan, Jacqueline A., Otto, Thomas D., Parkhill, Julian   +5 more
core   +1 more source