Results 111 to 120 of about 124,584 (310)

Evolution of virulence: triggering host inflammation allows invading pathogens to exclude competitors. [PDF]

, 2008
Virulence is generally considered to benefit parasites by enhancing resource-transfer from host to pathogen. Here, we offer an alternative framework where virulent immune-provoking behaviours and enhanced immune resistance are joint tactics of invading ...
Alizon S., Anderson R.M., Andre J.B., Dawkins R., Gordon D.M., Kerr B., Odling-Smee F.J., Otto S.P., Plunkett G., Poulin R.   +9 more
core   +2 more sources

Apolipophorin-III mediates antiplasmodial epithelial responses in Anopheles gambiae (G3) mosquitoes. [PDF]

PLoS ONE, 2010
Apolipophorin-III (ApoLp-III) is known to play an important role in lipid transport and innate immunity in lepidopteran insects. However, there is no evidence of involvement of ApoLp-IIIs in the immune responses of dipteran insects such as Drosophila and
Lalita Gupta, Ju Young Noh, Yong Hun Jo, Seung Han Oh, Sanjeev Kumar, Mi Young Noh, Yong Seok Lee, Sung-Jae Cha, Sook Jae Seo, Iksoo Kim, Yeon Soo Han, Carolina Barillas-Mury   +11 more
doaj   +1 more source

Anopheles gambiae Blood Feeding Initiates an Anticipatory Defense Response to Plasmodium berghei

Journal of Innate Immunity, 2014
Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pathogens. Much remains unknown about how different pathogens are sensed and specific responses triggered.
L. Upton, M. Povelones, G. Christophides
semanticscholar   +1 more source

Biosynthesis of the Red Algal Diterpene Peyssonnosol in Bacteria

Angewandte Chemie International Edition, Volume 64, Issue 34, August 18, 2025.
Two terpene synthases derived from Anaerolineae bacteria catalyse the biosynthesis of peyssonnosene‐type diterpenes from red algae. Site‐directed mutagenesis enabled a partial functional switch, resulting in the formation of additional byproducts. The intricate cyclisation mechanisms were investigated through isotopic labelling experiments and density ...
Zhiyong Yin, Zhehui Hu, Kexin Yang, Guihu Lu, Georges B. Tabekoueng, Pingping Wu, Qi Luo, Juan Xu, Bernd Goldfuss, Jeroen S. Dickschat, Guangkai Bian   +10 more
wiley   +1 more source

Methanol Extract of Ficus trigonata Stem Bark Demonstrated Antiplasmodial Activity in Mice

Baghdad Journal of Biochemistry and Applied Biological Sciences
Malaria, caused by Plasmodium parasites, remains a global health concern, with drug resistance complicating control efforts. Plant-derived compounds have emerged as potential antimalarial agents.
Suleiman mahmoud Jada, Yusuf Umar, Abdullahi Usman Wurochekke   +2 more
doaj   +1 more source

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands [PDF]

, 2010
Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host. We show that sporozoite latency is an active
Anat Caspi, Balagopal, Beatriz M.A. Fontoura, Boyce, Boyd, Bruña-Romero, Chakraborty, Chakraborty, Christian Doerig, Clare Fennell, Coppi, Dar, David S. Roos, Elizabeth A. Winzeler, Fennell, Ferreira da Silva, Florens, Gantt, Janse, Kaiser, Kappe, Kebaier, Kedersha, Khater, Lasonder, Le Roch, Lisa Ranford-Cartwright, Mair, Meis, Min Zhang, Mota, Mueller, Narasimhan, Pascale Gueirard, Paton, Porter, Proud, Ramanavelan Sakthivel, Renu Tuteja, Robert Ménard, Ruth S. Nussenzweig, Sherman, Stephan Meister, Sullivan, Sullivan, Thompson, Tsuji, Tuteja, Van Der Kelen, Vanderberg, Vervenne, Victor Nussenzweig, Ward, William J. Sullivan, Yamauchi, Yoshida, Yoshida, Zhou   +57 more
core   +2 more sources

The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei

International Journal for Parasitology: Drugs and Drug Resistance
Background: Studying and discovering the molecular mechanism of Plasmodium sexual development is crucial for the development of transmission blocking drugs and malaria eradication.
Xitong Jia, Yong Wang, Meilian Wang, Hui Min, Zehou Fang, Haifeng Lu, Jiao Li, Yaming Cao, Lunhao Bai, Jinghan Lu   +9 more
doaj   +1 more source

Ajuvant effect of a Synthetic Aluminium - Magnesium Silicate on chloroquine phosphate, against Plasmodium berghei. [PDF]

, 2012
effect of a synthetic Aluminium - Magnesium Silicate (AMS) on antiplasmodial activity of chloroquine was tested. Plasmodium berghei-infected mice were treated with 7 mg/kg, 5 mg/kg and 3 mg/kg chloroquine, respectively.
Augustine Ngene, madike ezeibe, nnenna elendu-eleke, obianuju obianuju Okoroafor   +3 more
core   +2 more sources

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs

Advanced NanoBiomed Research, Volume 5, Issue 8, August 2025.
Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng   +11 more
wiley   +1 more source

Exploration of Fluorinated Peptoid‐Based Histone Deacetylase Inhibitors as Dual‐Stage Antiplasmodial Agents

Archiv der Pharmazie, Volume 358, Issue 8, August 2025.
The antiplasmodial properties of a series of fluorinated peptoid‐based histone deacetylase (HDAC) inhibitors were evaluated by screening them for their activity against asexual blood and liver stage malaria parasites and assessing their mammalian cell toxicity, to elucidate structure–activity and structure‐toxicity relationships. Compound 1h emerged as
Nina Reßing, Daniel Stopper, Thomas Martin Schäfer, Lais Pessanha de Carvalho, Elizabeth A. Winzeler, Jana Held, Finn K. Hansen   +6 more
wiley   +1 more source