Results 91 to 100 of about 296,027 (331)

Tandem Mass Spectrometry and Bio‐Guided Isolation of Secondary Metabolites With Antiplasmodial Activity From Dalbergia miscolobium Bark

Chemistry &Biodiversity, EarlyView.
ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas, Igor M. R. Moura, Romário Pereira da Costa, Guilherme Eduardo de Souza, Richele Priscila Severino, Hélder Nagai Consolaro, Luis Felipe de Oliveira, Vinicius Bonatto, Quezia Bezerra Cass, Rafael V. C. Guido, Lorena Ramos Freitas de Sousa   +10 more
wiley   +1 more source

Detection of Plasmodium falciparum male and female gametocytes and determination of parasite sex ratio in human endemic populations by novel, cheap and robust RTqPCR assays [PDF]

, 2017
The presence of Plasmodium falciparum gametocytes in peripheral blood is essential for human to mosquito parasite transmission. The detection of submicroscopic infections with gametocytes and the estimation of the gametocyte sex ratio are crucial to ...
Alano, Pietro, Avellino, Pamela, Lombardo, Fabrizio, Mangano, Valentina Dianora, Modiano, David, Ouédraogo, Jean Bosco, Santolamazza, Federica, Siciliano, Giulia, Yao, Franck Adama   +8 more
core   +2 more sources

The prevalence of Plasmodium falciparum in sub Saharan Africa since 1900

Nature, 2017
Malaria transmission is influenced by climate, land use and deliberate interventions. Recent declines have been observed in malaria transmission. Here we show that the African continent has witnessed a long-term decline in the prevalence of Plasmodium ...
R. Snow, B. Sartorius, D. Kyalo, Joseph Maina, P. Amratia, Clara W. Mundia, P. Bejon, A. Noor   +7 more
semanticscholar   +1 more source

Batch Synthesis of Primaquine Diphosphate Anti‐Malarial Drug

Chemistry – A European Journal, EarlyView.
According to the WHO, a child under the age of five dies every 2 minutes from malaria in Africa. It is therefore paramount that access and availability of anti‐malarial drugs must be improved. We report a process for the synthesis of Primaquine Diphosphate, where key intermediates were obtained in a much shorter reaction time compared to processes ...
Faith M. Akwi, Simthandile Swartbooi, Paul Watts   +2 more
wiley   +1 more source

RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts. [PDF]

, 2011
Over 50% of genes in Plasmodium falciparum, the deadliest human malaria parasite, contain predicted introns, yet experimental characterization of splicing in this organism remains incomplete.
DeRisi, Joseph L, Dimon, Michelle T, Sorber, Katherine   +2 more
core   +3 more sources

Performance of Microscopy for the Diagnosis of Malaria and Human African Trypanosomiasis by Diagnostic Laboratories in the Democratic Republic of the Congo: Results of a Nation-Wide External Quality Assessment. [PDF]

PLoS ONE, 2016
The present External Quality Assessment (EQA) assessed microscopy of blood parasites among diagnostic laboratories in the Democratic Republic of the Congo. The EQA addressed 445 participants in 10/11 provinces (October 2013-April 2014). Participants were
Pierre Mukadi, Veerle Lejon, Barbara Barbé, Philippe Gillet, Christophe Nyembo, Albert Lukuka, Joris Likwela, Crispin Lumbala, Justin Mbaruku, Wim Vander Veken, Dieudonné Mumba, Pascal Lutumba, Jean-Jacques Muyembe, Jan Jacobs   +13 more
doaj   +1 more source

AgamOBP1‐Directed Discovery of Repellents to Control the Spread of Mosquito‐Borne Diseases

ChemMedChem, EarlyView.
Toward the discovery of novel mosquito repellents, a library of potential binders of AgamOBP1 (secondary amines) generated from two amines and seven aldehydes was designed aiming to enable interactions with critical amino acids at the DEET‐site and to bridge the DEET‐ and Icaridin sIC‐binding pockets. 1H STD NMR spectroscopy in the presence of AgamOBP1
Evanthia Chazapi, Eftichia Kritsi, Constantinos Potamitis, Panagiota G. V. Liggri, Katerina E. Tsitsanou, Christina E. Drakou, Antonios Michaelakis, Dimitrios P. Papachristos, Spyros E. Zographos, Maria Zervou, Theodora Calogeropoulou   +10 more
wiley   +1 more source

Sequence analysis of genes associated with resistance to chloroquine and sulphadoxine pyrimethamine in P. falciparum and P. vivax isolates from the Bannu district of Pakistan

Brazilian Journal of Infectious Diseases, 2013
Plasmodium vivax and Plasmodium falciparum are becoming resistant to drugs including antifolates, sulphonamides and chloroquine. This study was focused at sequence analysis of resistant genes of these parasites against sulphadoxine–pyrimethamine and ...
Lubna Khatoon, Frederick N. Baliraine, Salman A. Malik, Guiyun Yan   +3 more
doaj   +1 more source

False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

Malaria Journal, 2017
Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative
Christina Kozycki, Noella Umulisa, S. Rulisa, E. I. Mwikarago, J. Musabyimana, J. Habimana, C. Karema, D. Krogstad   +7 more
semanticscholar   +1 more source

Plasmodium falciparum « toutankhamonensis » [PDF]

Bulletin de la Société de pathologie exotique, 2010
Alexandre le Grand, les empereurs Titus et Othon II, Alaric, Olivier Cromwell, les papes Gregoire V, Leon X, Sixte V, Urbain VII, Alexandre VI, Borgia, Dante Alighieri, Byron, Le Caravage, Fausto Coppi... A la liste des victimes celebres, reelles, presumees ou imaginaires du paludisme, les medias viennent d’ajouter Toutankhamon sans se poser de ...
openaire   +2 more sources