Results 101 to 110 of about 287,184 (330)

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Performance of rapid diagnostic tests for imported malaria in clinical practice: results of a national multicenter study. [PDF]

PLoS ONE, 2013
We compared the performance of four rapid diagnostic tests (RDTs) for imported malaria, and particularly Plasmodium falciparum infection, using thick and thin blood smears as the gold standard.
Sandrine Houzé, Isabelle Boutron, Anne Marmorat, Marie Dalichampt, Christophe Choquet, Isabelle Poilane, Nadine Godineau, Anne-Sophie Le Guern, Marc Thellier, Hélène Broutier, Odile Fenneteau, Pascal Millet, Stéphanie Dulucq, Véronique Hubert, Pascal Houzé, Florence Tubach, Jacques Le Bras, Sophie Matheron   +17 more
doaj   +1 more source

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Nature, 2017
Malaria is among the most serious infectious diseases affecting humans, accounting for approximately half a million deaths each year. Plasmodium falciparum causes most life-threatening cases of malaria.
Fumiji Saito, Kouyuki Hirayasu, T. Satoh, Christian W. Wang, J. Lusingu, T. Arimori, K. Shida, N. Palacpac, Sawako Itagaki, S. Iwanaga, E. Takashima, T. Tsuboi, M. Kohyama, T. Suenaga, M. Colonna, J. Takagi, T. Lavstsen, T. Horii, H. Arase   +18 more
semanticscholar   +1 more source

Isoprenoid Biosynthesis in Plasmodium falciparum [PDF]

Eukaryotic Cell, 2014
ABSTRACT Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via the methylerythritol phosphate (MEP) pathway represents an attractive target for the development of new antimalarials ...
Guggisberg, Ann M, Amthor, Rachel E, Odom, Audrey R   +2 more
openaire   +3 more sources

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. [PDF]

PLoS ONE, 2011
Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium
María B Cassera, Keith Z Hazleton, Emilio F Merino, Nicanor Obaldia, Meng-Chiao Ho, Andrew S Murkin, Richard DePinto, Jemy A Gutierrez, Steven C Almo, Gary B Evans, Yarlagadda S Babu, Vern L Schramm   +11 more
doaj   +1 more source

False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

Malaria Journal, 2017
Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative
C. Kozycki, Noella Umulisa, S. Rulisa, E. I. Mwikarago, J. Musabyimana, J. Habimana, C. Karema, D. Krogstad   +7 more
semanticscholar   +1 more source

Antigenic variation in Plasmodium falciparum. [PDF]

Proceedings of the National Academy of Sciences, 1991
Antigenic variation of infectious organisms is a major factor in evasion of the host immune response. However, there has been no definitive demonstration of this phenomenon in the malaria parasite Plasmodium falciparum. In this study, cloned parasites were examined serologically and biochemically for the expression of erythrocyte surface antigens.
Biggs, BA, Goozé, L, Wycherley, K, Wollish, W, Southwell, B, Leech, JH, Brown, ZV   +6 more
openaire   +4 more sources

Structural and Functional Characterization of the 28 kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Babesiosis is a tick‐borne disease that poses a significant threat to animal health worldwide. In addition, climate change and the risk of human‐to‐human transmission through blood transfusion have made babesiosis an emerging disease in humans.
Assia Mouhand, Joana Pissarra, Philippe Barthe, Christian Roumestand, Stéphane Delbecq   +4 more
wiley   +1 more source

Plasmodium species occurrence, temporal distribution and interaction in a child-aged population in rural Burkina Faso

Malaria Journal, 2013
Background Malaria can be caused by five Plasmodium species. Due to their higher prevalence, much of the research concentrates on Plasmodium falciparum and Plasmodium vivax. In Burkina Faso, where P.
Gnémé Awa, Guelbéogo Wamdaogo M, Riehle Michelle M, Tiono Alfred B, Diarra Amidou, Kabré Gustave B, Sagnon N’falé, Vernick Kenneth D   +7 more
doaj   +1 more source