Results 101 to 110 of about 296,027 (331)

C1′‐Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6‐Oxopurine Phosphoribosyltransferase

ChemMedChem, EarlyView.
Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych, Dianne T. Keough, Haojun Xia, Lenka Poštová Slavětínská, Martin Dračínský, Michal Česnek, Jye Travis, Marina Chavchich, Michael Edstein, Dana Hocková, Luke W. Guddat, Zlatko Janeba   +11 more
wiley   +1 more source

Inactivation of Plasmodium falciparum in whole blood by riboflavin plus irradiation.

, 2013
BACKGROUND: Malaria parasites are frequently transmitted by unscreened blood transfusions in Africa. Pathogen reduction methods in whole blood would thus greatly improve blood safety.
Allain, Jean-Pierre, Atwal, Sharan, Dinko, Bismarck, El Chaar, Mira, Freimanis, Graham L, Sutherland, Colin J   +5 more
core   +1 more source

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Nature, 2017
Malaria is among the most serious infectious diseases affecting humans, accounting for approximately half a million deaths each year. Plasmodium falciparum causes most life-threatening cases of malaria.
Fumiji Saito, Kouyuki Hirayasu, T. Satoh, Christian W. Wang, J. Lusingu, T. Arimori, K. Shida, N. Palacpac, Sawako Itagaki, S. Iwanaga, E. Takashima, T. Tsuboi, M. Kohyama, T. Suenaga, M. Colonna, J. Takagi, T. Lavstsen, T. Horii, H. Arase   +18 more
semanticscholar   +1 more source

Isoprenoid Biosynthesis in Plasmodium falciparum [PDF]

Eukaryotic Cell, 2014
ABSTRACT Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via the methylerythritol phosphate (MEP) pathway represents an attractive target for the development of new antimalarials ...
Guggisberg, Ann M, Amthor, Rachel E, Odom, Audrey R   +2 more
openaire   +3 more sources

FIGO good practice recommendations on anemia in pregnancy, to reduce the incidence and impact of postpartum hemorrhage (PPH)

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Anemia affects 32 million pregnant women globally, contributing annually to more than 115 000 maternal deaths and 591 000 perinatal deaths worldwide. Low‐ and middle‐income countries (LMICs) bear the highest burden of anemia in pregnancy, with nearly 50% of affected pregnant women. It is now 2025, which is WHO's target year for a 50% reduction
Akaninyene E. Ubom, Ferdousi Begum, Diana Ramasauskaite, Albaro J. Nieto‐Calvache, Monica Oguttu, Inês Nunes, Zechariah J. Malel, Jolly Beyeza‐Kashesya, Alison Wright, on behalf of the FIGO Committee on Childbirth and Postpartum Hemorrhage   +9 more
wiley   +1 more source

Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development. [PDF]

, 2014
BACKGROUND: Gametocytes are the Plasmodium life stage that is solely responsible for malaria transmission. Despite their important role in perpetuating malaria, gametocyte differentiation and development is poorly understood.
Delves, MJ, Lamour, SD, Saric, J, Straschil, U   +3 more
core   +3 more sources

Antigenic variation in Plasmodium falciparum. [PDF]

Proceedings of the National Academy of Sciences, 1991
Antigenic variation of infectious organisms is a major factor in evasion of the host immune response. However, there has been no definitive demonstration of this phenomenon in the malaria parasite Plasmodium falciparum. In this study, cloned parasites were examined serologically and biochemically for the expression of erythrocyte surface antigens.
Biggs, BA, Goozé, L, Wycherley, K, Wollish, W, Southwell, B, Leech, JH, Brown, ZV   +6 more
openaire   +4 more sources

Unstained Blood Smear Analysis: A Review of Rule‐Based, Machine Learning, and Deep Learning Techniques

Journal of Biophotonics, EarlyView.
Bright‐field images of unstained smears. (1) Sparse erythrocytes allow straightforward intensity‐ or phase‐based segmentation. (2) Overlapping cells blur boundaries, causing over‐ or under‐segmentation and lowering rule‐based accuracy, thus motivating overlap‐aware algorithms for reliable downstream feature extraction and classification. ABSTRACT Blood
Husnu Baris Baydargil, Thomas Bocklitz
wiley   +1 more source

Indels, structural variation, and recombination drive genomic diversity inPlasmodium falciparum [PDF]

, 2016
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. Current understanding of parasite evolution is impeded by the fact that a large fraction of the genome is ...
Campino, Susana, Drury, Eleanor, Ferdig, Michael, Gould, Kelda, Hayton, Karen, Iqbal, Zamin, Kwiatkowski, Dominic, MacInnis, Bronwyn, McVean, Gil, Mead, Daniel, Miles, Alistair, Mwangi, Jonathan, O'Brien, John, Pearson, Richard, Ranford-Cartwright, Lisa, Rayner, Julian, Ruano Rubio, Valentin, Samarakoon, Upeka, Su, Xin-zhuan, Theron, Michel, Vauterin, Paul, Wellems, Thomas   +21 more
core   +3 more sources

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. [PDF]

PLoS ONE, 2011
Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium
María B Cassera, Keith Z Hazleton, Emilio F Merino, Nicanor Obaldia, Meng-Chiao Ho, Andrew S Murkin, Richard DePinto, Jemy A Gutierrez, Steven C Almo, Gary B Evans, Yarlagadda S Babu, Vern L Schramm   +11 more
doaj   +1 more source