Results 111 to 120 of about 287,184 (330)
Aminoisothiazolamides, a new class of potent inhibitors of lysyl‐tRNA synthetase
Pest Management Science, EarlyView.The present work covers a series of novel herbicidal lead structures that possess an aminoisothiazolamide scaffold as a structural key feature. Lysyl‐tRNA synthetase 1 (KRS1) was identified as the biochemical mode‐of‐action. Based on optimized and tailored synthetic approaches, a broader SAR study was carried out delivering some lead structures that ...
David Bernier +26 more
wiley +1 more source
Submicroscopic placental infection by non-falciparum Plasmodium spp. [PDF]
PLoS Neglected Tropical Diseases, 2018 Among the Plasmodium species that infect humans, adverse effects of P. falciparum and P. vivax have been extensively studied and reported with respect to poor outcomes particularly in first time mothers and in pregnant women living in areas with unstable
Justin Y A Doritchamou +6 more
doaj +1 more source
Cessation of mass drug administration for lymphatic filariasis in Zanzibar in 2006: was transmission interrupted? [PDF]
, 2015 BACKGROUND: Lymphatic filariasis (LF) is targeted for elimination through annual mass drug administration (MDA) for 4-6 years. In 2006, Zanzibar stopped MDA against LF after five rounds of MDA revealed no microfilaraemic individuals during surveys at ...
Cullen, Katelyn J +10 more
core +7 more sources
Small, EarlyView.This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai +5 more
wiley +1 more source
Combating multidrug‐resistant Plasmodium falciparum malaria
The FEBS Journal, 2017 Over the past 50 years, Plasmodium falciparum has developed resistance against all antimalarial drugs used against it: chloroquine, sulphadoxine–pyrimethamine, quinine, piperaquine and mefloquine.
A. Thu +4 more
semanticscholar +1 more source
Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway [PDF]
, 2012 Background Protein kinase CK2 is a pleiotropic serine/threonine protein kinase with hundreds of reported substrates, and plays an important role in a number of cellular processes.
Chene, A. +11 more
core +5 more sources
Molecular Ecology Resources, EarlyView.ABSTRACT Vector control remains an important strategy worldwide to prevent human infection with pathogens transmitted by arthropods. Vector control strategies rely on accurate identification of vector taxa along with vector‐specific biological indicators such as feeding ecology, infection prevalence and insecticide resistance.
Raquel Lima‐Cordón +18 more
wiley +1 more source
Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixed-species malaria in Gabon [PDF]
, 2012 Background: The recommendation of artemisinin combination therapy (ACT) as first-line treatment for uncomplicated falciparum malaria is supported by a plethora of high quality clinical trials.
Adegnika, Ayola A. +12 more
core +1 more source
The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
Aging Cell, EarlyView.Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond
Muthu Saravanan Manoharan +176 more
wiley +1 more source
Pakistan Armed Forces Medical JournalObjective: To test the sensitivity of locally available strips for the detection of Plasmodium Vivax and Plasmodium Falciparum species at a tertiary care hospital. Study Design: Cross-sectional study.
Nabila Rafique +5 more
doaj +1 more source