Results 131 to 140 of about 192,328 (309)

Plasmodium falciparum: multifaceted resistance to artemisinins

Malaria Journal, 2016
Plasmodium falciparum resistance to artemisinins, the most potent and fastest acting anti-malarials, threatens malaria elimination strategies. Artemisinin resistance is due to mutation of the PfK13 propeller domain and involves an unconventional ...
L. Paloque, A. Ramadani, O. Mercereau‐Puijalon, J. Augereau, F. Benoit‐Vical   +4 more
semanticscholar   +1 more source

Phylogeny of plasmodium falciparum [PDF]

Parasitology Today, 1992
Ayala, FJ, Fitch, WM
openaire   +4 more sources

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

The FEBS Journal, EarlyView.
Compounds were identified that inhibit the aspartic protease plasmepsin V from Plasmodium vivax. Further development of these compounds identified compounds, such as S‐WM48, that could inhibit both plasmepsin V and plasmepsin X but plasmepsin IX was not significantly inhibited.
Anthony N. Hodder, Brad E. Sleebs, Greg Adams, Sina Rezazadeh, Anna Ngo, Kate Jarman, Stephen Scally, Peter Czabotar, Hongwu Wang, John A. McCauley, David B. Olsen, Alan F. Cowman   +11 more
wiley   +1 more source

DNA to DNA transcription might exist in eukaryotic cells [PDF]

arXiv, 2016
Till now, in biological sciences, the term, transcription, mainly refers to DNA to RNA transcription. But our recently published experimental findings obtained from Plasmodium falciparum strongly suggest the existence of DNA to DNA transcription in the genome of eukaryotic cells, which could shed some light on the functions of certain noncoding DNA in ...
arxiv  

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

Science, 2015
Mechanisms propelling drug resistance If it were to spread, resistance to the drug artemisinin would seriously derail the recent gains of global malaria control programs (see the Perspective by Sibley).
J. Straimer, Nina F. Gnädig, B. Witkowski, C. Amaratunga, V. Duru, A. Ramadani, Mélanie A. Dacheux, N. Khim, Lei Zhang, Stephen C. Lam, P. Gregory, F. Urnov, O. Mercereau‐Puijalon, F. Benoit‐Vical, R. Fairhurst, D. Ménard, D. Fidock   +16 more
semanticscholar   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

The FEBS Journal, EarlyView.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés, Aida Beà, Anna Sancho‐Balsells, Juan G Valero, David Aluja, Javier Inserte, Sandra García‐Carpi, Elisabet Miró‐Casas, Sara Borràs‐Pernas, Sara Hernández, Ana Martínez‐Val, Jesper V Olsen, Francesc Tebar, Xavier Cañas, Joan X. Comella, Patricia Pérez‐Galán, Marisol Ruiz‐Meana, Albert Giralt, Marta Llovera, Daniel Sanchis   +19 more
wiley   +1 more source

Evaluation of the rapid diagnostic test SDFK40 (Pf-pLDH/pan-pLDH) for the diagnosis of malaria in a non-endemic setting

Malaria Journal, 2011
Background The present study evaluated the SD Bioline Malaria Ag 05FK40 (SDFK40), a three-band RDT detecting Plasmodium falciparum-specific parasite lactate dehydrogenase (Pf-pLDH) and pan Plasmodium-specific pLDH (pan-pLDH), in a reference setting ...
Van Esbroeck Marjan, Bottieau Emmanuel, Cnops Lieselotte, Gillet Philippe, Maltha Jessica, Bruggeman Cathrien, Jacobs Jan   +6 more
doaj   +1 more source

Implications of Parasites Lacking Plasmodium falciparum Histidine-Rich Protein 2 on Malaria Morbidity and Control When Rapid Diagnostic Tests Are Used for Diagnosis

Journal of Infectious Diseases, 2017
Background Rapid diagnostic tests (RDTs) are an important tool for malaria diagnosis, with most using antibodies against Plasmodium falciparum histidine-rich protein 2 (PfHRP2). Reports of P.
M. Gatton, J. Dunn, A. Chaudhry, Sadmir Ciketic, J. Cunningham, Q. Cheng   +5 more
semanticscholar   +1 more source

New insights into Sti1/Hop's cochaperone function highlight the complexity of proteostatic regulation

The FEBS Journal, EarlyView.
Sti1/Hop functions extend beyond scaffolding in the Hsp70‐Hsp90 chaperone complex to sequester misfolded proteins during cell stress. Consequently, imbalances between levels of Sti1/Hop relative to the rest of the proteostasis machinery negatively affect fitness and stress resilience. Sti1/Hop is a cochaperone that regulates Hsp70 and Hsp90 chaperones.
Gregory Lloyd Blatch, Adrienne Lesley Edkins   +1 more
wiley   +1 more source

Assessing the burden of submicroscopic Plasmodium infections in a pre-elimination malaria setting in sub-Saharan Africa, Guinea-Bissau

Malaria Journal
Background Submicroscopic Plasmodium infections can be a source of persistent malaria transmission. The aim of this study was to assess their frequency, distribution, morbidity and associated factors in a pre-elimination malaria setting in sub-Saharan ...
Ronise Silva, Luis Filipe Lopes, Amabelia Rodrigues, Ana Paula Arez, Márcia M. Medeiros   +4 more
doaj   +1 more source