Results 131 to 140 of about 296,027 (331)

Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

Nature Microbiology, 2017
Plasmodium parasites, the causative agents of malaria, have evolved a unique cell division cycle in the clinically relevant asexual blood stage of infection1. DNA replication commences approximately halfway through the intracellular development following
Markus Ganter, J. Goldberg, Jeffrey D. Dvorin, J. Paulo, Jonas G King, A. Tripathi, Aditya S. Paul, Jing Yang, I. Coppens, R. Jiang, Brendan Elsworth, D. Baker, R. Dinglasan, S. Gygi, M. Duraisingh   +14 more
semanticscholar   +1 more source

Stress in dipteran insects mass‐reared for sterile insect technique applications

Insect Science, EarlyView.
The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri, Vera I.D. Ros, Adly M.M. Abd‐Alla, Monique M. van Oers   +3 more
wiley   +1 more source

Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach [PDF]

, 2017
The symptoms of malaria are brought about by blood-stage parasites, which are established when merozoites invade human erythrocytes. Our understanding of the molecular events that underpin erythrocyte invasion remains hampered by the short-period of time
Geromanos, Scott J., Haynes, J. David, Herrera, Raul, Kumar, Krishan, Moch, J. Kathleen, Nagarajan, Vijayaraj, Narum, David L., Nold, Michael J., Otto, Thomas D., Porcella, Stephen F., Rayner, Julian C., Reiter, Karine, Squires, R. Burke, Srinivasan, Prakash, Sturdevant, Dan   +14 more
core   +2 more sources

Extreme mutation bias and high AT content in Plasmodium falciparum

Nucleic Acids Research, 2016
For reasons that remain unknown, the Plasmodium falciparum genome has an exceptionally high AT content compared to other Plasmodium species and eukaryotes in general - nearly 80% in coding regions and approaching 90% in non-coding regions.
W. Hamilton, A. Claessens, T. Otto, M. Kekre, R. Fairhurst, J. Rayner, D. Kwiatkowski   +6 more
semanticscholar   +1 more source

Enrichment of Helminth Mitochondrial Genomes From Faecal Samples Using Hybridisation Capture

Molecular Ecology Resources, EarlyView.
ABSTRACT New approaches are urgently needed to enrich rare or low‐abundant DNA in complex samples. Soil‐transmitted helminths (STHs) inhabit heterogeneous environments, including the gastrointestinal tract of their host as adults and are excreted as eggs and larvae in faeces, complicating our understanding of their biology and the use of genetic tools ...
Marina Papaiakovou, Andrea Waeschenbach, Roy M. Anderson, Piet Cools, Zeleke Mekonnen, D. Timothy J. Littlewood, Cinzia Cantacessi, Stephen R. Doyle   +7 more
wiley   +1 more source

Epidemiological data of falciparum malaria in Ado-Odo/Ota, Southwest Ogun State, Nigeria

Data in Brief, 2018
In this data article, Blood and corresponding saliva samples from subjects presenting with fever and parasetaemia ≥2000 were obtained from selected hospitals in Ado-Odo/Ota, Ogun State over a period of two years and analyzed using Polymerase chain ...
I.Ruth Diji-geske, I.Grace Olasehinde, Irawo Fadinad, Damola Arogundade, Precious Darby   +4 more
doaj   +1 more source

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

Nature Communications, 2015
The mechanism of action of artemisinin and its derivatives, the most potent of the anti-malarial drugs, is not completely understood. Here we present an unbiased chemical proteomics analysis to directly explore this mechanism in Plasmodium falciparum. We
Jigang Wang, Chong-Jing Zhang, W. Chia, Cheryl C. Y. Loh, Zhengjun Li, Y. Lee, Yingke He, Li-xia Yuan, T. Lim, Min Liu, C. Liew, Yan Quan Lee, Jianbin Zhang, Nianci Lu, C. Lim, Z. Hua, B. Liu, Han-Ming Shen, K. Tan, Q. Lin   +19 more
semanticscholar   +1 more source

Internationally Adopted and Migrant Children Had Important Health Issues Requiring Systematic Initial Screening at Arrival

Acta Paediatrica, EarlyView.
ABSTRACT Aim Internationally adopted and migrant children have similar profiles as they may have experienced many adversities before arrival in their new country. We sought to compare both groups at arrival, focusing on nutritional status, infections and vaccination status.
Céline Lafay, Laurie Miller, Juliette Goutines, Enora Leroux, Albert Faye, Frédéric Sorge   +5 more
wiley   +1 more source

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Adjuik, M, Barnes, K, Day, N P J, Farrar, J, Guthmann, J P, Hien, T T, Looareesuwan, S, Mayxay, M, Myint, H Y, Nosten, F, Olliaro, P, Price, R, Pukrittayakamee, S, Smithuis, F, Stepniewska, K, Taylor, W R J, White, N J   +16 more
core   +3 more sources

Genetic association between the Pfk13 gene mutation and artemisinin resistance phenotype in Plasmodium falciparum isolates from Yunnan Province, China

Malaria Journal, 2018
Background The problem of anti-malarial drug resistance is a long-term challenge faced by malaria control in Yunnan Province. Recently, the detection rates of chloroquine-resistant molecular markers (Plasmodium falciparum chloroquine resistant ...
Ying Dong, Jian Wang, Aiming Sun, Yan Deng, Mengni Chen, Yanchun Xu, Jingpo Xue   +6 more
doaj   +1 more source