Results 91 to 100 of about 515,233 (262)
Frontiers in Cellular and Infection Microbiology, 2021 Malaria caused by Plasmodium species and transmitted by Anopheles mosquitoes affects large human populations, while Ixodes ticks transmit Babesia species and cause babesiosis.
Vitomir Djokic +2 more
doaj +1 more source
Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes
Cell Biology International, EarlyView.ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio +6 more
wiley +1 more source
Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach [PDF]
, 2017 The symptoms of malaria are brought about by blood-stage parasites, which are established when merozoites invade human erythrocytes. Our understanding of the molecular events that underpin erythrocyte invasion remains hampered by the short-period of time
Geromanos, Scott J. +14 more
core +2 more sources
Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor. [PDF]
PLoS Pathogens, 2015 Stage-specific transcription is a fundamental biological process in the life cycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation and belong to the only known ...
Izumi Kaneko +4 more
doaj +1 more source
Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives
ChemMedChem, EarlyView.Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi +7 more
wiley +1 more source
Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? [PDF]
, 2006 The organization and mining of malaria genomic and post-genomic data is highly motivated by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data
Bastien, Olivier +14 more
core +4 more sources
Proceedings, 2017 There currently exists a dire need for safe and inexpensive new antimalarial drugs, which are effective against multiple life cycle stages of Plasmodium falciparum, and act through mechanisms that differ from those of the available drugs to prevent drug ...
Caterina Pont +13 more
doaj +1 more source
Identification and characterization of a liver stage-specific promoter region of the malaria parasite Plasmodium. [PDF]
PLoS ONE, 2010 During the blood meal of a Plasmodium-infected mosquito, 10 to 100 parasites are inoculated into the skin and a proportion of these migrate via the bloodstream to the liver where they infect hepatocytes.
Susanne Helm +6 more
doaj +1 more source
Unveiling the Sugary Secrets of Plasmodium Parasites
Frontiers in Microbiology, 2021 Plasmodium parasites cause malaria disease, one of the leading global health burdens for humanity, infecting hundreds of millions of people each year.
Felix Goerdeler +4 more
doaj +1 more source
Food Frontiers, EarlyView.This review systematically and comprehensively analyzes hawthorn (Crataegus spp.), covering its bioactive constituents, properties, and processed products. ABSTRACT Hawthorn is widely cultivated in China, with excellent varieties and steadily increasing production.
Wenteng Yang +7 more
wiley +1 more source