Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members. [PDF]
, 2014 Emerging pathogens undermine initiatives to control the global health impact of infectious diseases. Zoonotic malaria is no exception. Plasmodium knowlesi, a malaria parasite of Southeast Asian macaques, has entered the human population. P.
A Berry +61 more
core +3 more sources
H2S Is a Potential Universal Reducing Agent for Prx6‐Type Peroxiredoxins
Advanced Science, EarlyView.We report the identification of H2S as reducing agent for Prx6‐type peroxiredoxins. In contrast to common physiological reducing agents of other peroxiredoxins, HS− is small enough to access the active site of oxidized Prx6‐type enzymes in the fully‐folded protein conformation.
Lukas Lang +3 more
wiley +1 more source
Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor. [PDF]
PLoS Pathogens, 2015 Stage-specific transcription is a fundamental biological process in the life cycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation and belong to the only known ...
Izumi Kaneko +4 more
doaj +1 more source
Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? [PDF]
, 2006 The organization and mining of malaria genomic and post-genomic data is highly motivated by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data
Bastien, Olivier +14 more
core +4 more sources
In Vitro Monitoring of Babesia microti Infection Dynamics in Whole Blood Microenvironments
Advanced Science, EarlyView.Here, an open microfluidic platform termed “µ‐Blood” is reported for real‐time, continuous monitoring of Babesia microti infection dynamics in vitro. µ‐Blood allows direct interrogation of whole blood with preserved integrity of the original whole blood microenvironment through an extended period (e.g., 72 h with mouse red blood cells) ex vivo. µ‐Blood
Chao Li +4 more
wiley +1 more source
Proceedings, 2017 There currently exists a dire need for safe and inexpensive new antimalarial drugs, which are effective against multiple life cycle stages of Plasmodium falciparum, and act through mechanisms that differ from those of the available drugs to prevent drug ...
Caterina Pont +13 more
doaj +1 more source
Identification and characterization of a liver stage-specific promoter region of the malaria parasite Plasmodium. [PDF]
PLoS ONE, 2010 During the blood meal of a Plasmodium-infected mosquito, 10 to 100 parasites are inoculated into the skin and a proportion of these migrate via the bloodstream to the liver where they infect hepatocytes.
Susanne Helm +6 more
doaj +1 more source
Unveiling the Sugary Secrets of Plasmodium Parasites
Frontiers in Microbiology, 2021 Plasmodium parasites cause malaria disease, one of the leading global health burdens for humanity, infecting hundreds of millions of people each year.
Felix Goerdeler +4 more
doaj +1 more source
Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages [PDF]
, 2009 Malaria pathology is caused by multiplication of asexual parasites within erythrocytes, whereas mosquito transmission of malaria is mediated by sexual precursor cells (gametocytes).
Beitz +37 more
core +4 more sources
Advanced Science, EarlyView.This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Nedal Darif +12 more
wiley +1 more source