Results 91 to 100 of about 67,974 (216)

Thrombospondin Related Anonymous Protein Superfamily in Vector-Borne Apicomplexans: The Parasite’s Toolkit for Cell Invasion

Frontiers in Cellular and Infection Microbiology, 2022
Apicomplexan parasites transmitted by vectors, including Babesia spp. and Plasmodium spp., cause severe disease in both humans and animals. These parasites have a complex life cycle during which they migrate, invade, and replicate in contrasting hosts ...
Martina Soledad Paoletta, Silvina Elizabeth Wilkowsky   +1 more
doaj   +1 more source

Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach [PDF]

, 2019
We introduce an agent-based model describing a susceptible-infectious-susceptible (SIS) system of humans and mosquitoes to predict malaria epidemiological scenarios in realistic biological conditions.
Lind, Pedro G., Louçã, Jorge, Mendes, António M., Sequeira, João   +3 more
core   +2 more sources

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

Predicting the direct and indirect impacts of climate change on malaria in coastal Kenya.

PLoS ONE, 2019
BACKGROUND:The transmission of malaria is highly variable and depends on a range of climatic and anthropogenic factors. This study investigates the combined, i.e.
Phong V V Le, Praveen Kumar, Marilyn O Ruiz, Charles Mbogo, Ephantus J Muturi   +4 more
doaj   +1 more source

Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies

Microorganisms, 2023
Malaria elimination may never succeed without the implementation of transmission-blocking strategies. The transmission of Plasmodium spp. parasites from the human host to the mosquito vector depends on circulating gametocytes in the peripheral blood of ...
Dinkorma T. Ouologuem, Antoine Dara, Aminatou Kone, Amed Ouattara, Abdoulaye A. Djimde   +4 more
doaj   +1 more source

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

PLOS Genetics, 2019
Determining the genetic basis of fitness is central to understanding evolution and transmission of microbial pathogens. In human malaria parasites (Plasmodium falciparum), most experimental work on fitness has focused on asexual blood stage parasites, because this stage can be easily cultured, although the transmission of malaria requires both female ...
Xue Li, Sudhir Kumar, Marina McDew‐White, Meseret T. Haile, Ian H. Cheeseman, Scott Emrich, Katrina A. Button-Simons, François Nosten, Stefan H. I. Kappe, Michael T. Ferdig, Tim Anderson, Ashley M. Vaughan   +11 more
openaire   +4 more sources

Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle [PDF]

Genome Research, 2004
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for
Karine G, Le Roch, Jeffrey R, Johnson, Laurence, Florens, Yingyao, Zhou, Andrey, Santrosyan, Munira, Grainger, S Frank, Yan, Kim C, Williamson, Anthony A, Holder, Daniel J, Carucci, John R, Yates, Elizabeth A, Winzeler   +11 more
openaire   +2 more sources

Effects of Vector Density on Blood Parasite Spread and Health Consequences for Avian Hosts: An Experimental Epidemiology Blueprint

Integrative Zoology, EarlyView.
In an experimental epidemiology setup, groups of pigeons were exposed to different numbers of infective malaria vectors. Vector number explained the speed of transmission, the final prevalence, and changes in host behavior. ABSTRACT Vector density plays a critical role in the transmission dynamics of vector‐borne diseases and thus in their health and ...
Nayden Chakarov, Tim Brandler, Kai Fischer, Carmen Schwietz   +3 more
wiley   +1 more source

Development of reverse-transcription PCR techniques to analyse the density and sex ratio of gametocytes in genetically diverse Plasmodium chabaudi infections [PDF]

, 2007
We have developed cross-genotype and genotype-specific quantitative reverse-transcription PCR (qRT-PCR) assays to detect and quantify the number of parasites, transmission stages (gametocytes) and male gametocytes in blood stage Plasmodium chabaudi ...
Abdel-Wahab, Alano, Babiker, Bell, Cheeseman, Damien R. Drew, De Roode, De Roode, De Roode, Dye, Ferguson, Ferguson, Foster, Gardner, Gautret, Hamilton, Khan, Mackinnon, Nee, Paterson, Paul, Paul, Paul, Pinheiro, Ranford-Cartwright, Read, Read, Read, Reece, Reece, Reece, Sarah E. Reece, Schall, Schall, Schneider, Shutler, Sinden, Taylor, Taylor, Wargo, Wargo, West, West, West, West   +44 more
core   +1 more source

An ultrasensitive NanoLuc-based luminescence system for monitoring Plasmodium berghei throughout its life cycle [PDF]

Malaria Journal, 2016
Bioluminescence imaging is widely used for cell-based assays and animal imaging studies, both in biomedical research and drug development. Its main advantages include its high-throughput applicability, affordability, high sensitivity, operational simplicity, and quantitative outputs. In malaria research, bioluminescence has been used for drug discovery
De Niz Hidalgo, Mariana Isabel, Limenitakis Stanway, Rebecca, Wacker, Rahel Corina, Keller, Derya, Heussler, Volker T.   +4 more
openaire   +3 more sources