Results 101 to 110 of about 515,233 (262)

Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach [PDF]

, 2019
We introduce an agent-based model describing a susceptible-infectious-susceptible (SIS) system of humans and mosquitoes to predict malaria epidemiological scenarios in realistic biological conditions.
Lind, Pedro G., Louçã, Jorge, Mendes, António M., Sequeira, João   +3 more
core   +2 more sources

Thrombospondin Related Anonymous Protein Superfamily in Vector-Borne Apicomplexans: The Parasite’s Toolkit for Cell Invasion

Frontiers in Cellular and Infection Microbiology, 2022
Apicomplexan parasites transmitted by vectors, including Babesia spp. and Plasmodium spp., cause severe disease in both humans and animals. These parasites have a complex life cycle during which they migrate, invade, and replicate in contrasting hosts ...
Martina Soledad Paoletta, Silvina Elizabeth Wilkowsky   +1 more
doaj   +1 more source

Unstained Blood Smear Analysis: A Review of Rule‐Based, Machine Learning, and Deep Learning Techniques

Journal of Biophotonics, EarlyView.
Bright‐field images of unstained smears. (1) Sparse erythrocytes allow straightforward intensity‐ or phase‐based segmentation. (2) Overlapping cells blur boundaries, causing over‐ or under‐segmentation and lowering rule‐based accuracy, thus motivating overlap‐aware algorithms for reliable downstream feature extraction and classification. ABSTRACT Blood
Husnu Baris Baydargil, Thomas Bocklitz
wiley   +1 more source

Detecting signatures of balancing selection to identify targets of anti-parasite immunity.

, 2010
Parasite antigen genes might evolve under frequency-dependent immune selection. The distinctive patterns of polymorphism that result can be detected using population genetic methods that test for signatures of balancing selection, allowing genes encoding
Conway, David J, Weedall, Gareth D
core   +1 more source

Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages [PDF]

, 2009
Malaria pathology is caused by multiplication of asexual parasites within erythrocytes, whereas mosquito transmission of malaria is mediated by sexual precursor cells (gametocytes).
Beitz, Billker, Bork, Bystrom, CCP4, Daily, Darbon, Deitsch, Duraisingh, Emsley, Feese, Fivelman, Gouet, Greenwood, Guan, Hansen, Herzberg, Holz, Hurley, Hurley, Liu, Mair, McCabe, Murshudov, Ormo, Perrakis, Promeneur, Roudier, Sambrook, Santiago, Sharp, Studier, Trager, Vagin, Vial, Witteveen, Yeh, Young   +37 more
core   +4 more sources

Predicting the direct and indirect impacts of climate change on malaria in coastal Kenya.

PLoS ONE, 2019
BACKGROUND:The transmission of malaria is highly variable and depends on a range of climatic and anthropogenic factors. This study investigates the combined, i.e.
Phong V V Le, Praveen Kumar, Marilyn O Ruiz, Charles Mbogo, Ephantus J Muturi   +4 more
doaj   +1 more source

Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies

Microorganisms, 2023
Malaria elimination may never succeed without the implementation of transmission-blocking strategies. The transmission of Plasmodium spp. parasites from the human host to the mosquito vector depends on circulating gametocytes in the peripheral blood of ...
Dinkorma T. Ouologuem, Antoine Dara, Aminatou Kone, Amed Ouattara, Abdoulaye A. Djimde   +4 more
doaj   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development. [PDF]

, 2014
BACKGROUND: Gametocytes are the Plasmodium life stage that is solely responsible for malaria transmission. Despite their important role in perpetuating malaria, gametocyte differentiation and development is poorly understood.
Delves, MJ, Lamour, SD, Saric, J, Straschil, U   +3 more
core   +3 more sources

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source