Results 101 to 110 of about 36,588 (218)

Unveiling the Leishmanicidal Mechanism of 4‐Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Fabiana Brusco Lorenzetti, Rodolfo Bento Balbinot, Danielle Lazarin‐Bidóia, Viviane dos Santos Faiões, Eduardo Caio Torres‐Santos, Celso Vataru Nakamura, Tânia Ueda‐Nakamura, Diógenes Aparício Garcia Cortez, Benedito Prado Dias Filho   +8 more
wiley   +1 more source

9‐Deoxymuzigadial, a Sesquiterpene Isolated From Drimys brasiliensis (Winteraceae), Displays Reduced Cytotoxicity In Vitro and Modulates Leukocyte Activity and Fibrogenesis In Vivo

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The aims of this study were to investigate in vitro cytotoxic potential and the effects of daily administration during the inflammatory response induced by sponge implants in mice of the sesquiterpene 9‐deoxymuzigadial (9‐DOM), isolated from Drimys brasiliensis (Winteraceae).
Bruno Antonio Ferreira, Isabella Silva Cassimiro, Francyelle Borges Rosa de Moura, Tais de Campos Lima, Danielle Reis Napolitano, Eric Umehara, João Henrique Ghilardi Lago, Fernanda de Assis Araújo   +7 more
wiley   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

The Malaria Cell Atlas: a comprehensive reference of single parasite transcriptomes across the complete Plasmodium life cycle [PDF]

, 2019
Virginia M. Howick, Andrew J. C. Russell, Tallulah Andrews, Haynes Heaton, Adam J. Reid, Kedar Nath Natarajan, Hellen Butungi, Tom Metcalf, Lisa Verzier, Julian C. Rayner, Matthew Berriman, Jeremy K. Herren, Oliver Billker, Martin Hemberg, Arthur M. Talman, Mara Lawniczak   +15 more
openalex   +1 more source

Use of Contaminated Habitat and Associated Selenium Uptake Mediate Haemosporidian Parasite Infections in Wild Passerine Birds

Ecology and Evolution, Volume 16, Issue 1, January 2026.
We conducted a community‐scale field study to evaluate whether trace element contaminants derived from coal combustion residuals and nuclear fission products alter the dynamics of haemosporidian blood parasites, dipteran vectors, and avian hosts in riparian and wetland habitats in South Carolina, USA.
Courtney S. Werner, Mary Chapman, Daniel A. H. Peach, Travis L. DeVault, Olin E. Rhodes Jr.   +4 more
wiley   +1 more source

Plasmodium falciparum rhoptry proteins play diverse roles in the asexual erythrocytic life cycle, including in erythrocyte invasion, protein export and nutrient import

, 2018
Emma S. Sherling
openalex   +1 more source

Vector Potential Index: Bridging Competence and Contribution as an Integrative Measure of Relative Transmission Capability

Ecology and Evolution, Volume 16, Issue 1, January 2026.
The Vector Potential Index (VPI) is a novel metric for evaluating and comparing the potential of blood‐feeding arthropod vectors to contribute to zoonotic vector‐borne disease transmission. Taking a meta‐analysis approach, the VPI combines vector competence and host use data obtained from scientific literature to assign relative and absolute VPI ranks ...
Amely M. Bauer, Nathan D. Burkett‐Cadena, Lawrence E. Reeves, Barry W. Alto, Lindsay P. Campbell   +4 more
wiley   +1 more source

Amphibian Strategies Against Attacks by Flies: Host‐Specificity and Threats

Ecology and Evolution, Volume 16, Issue 1, January 2026.
Species interactions between Diptera flies and amphibians play a significant role in tropical ecosystems, but their ecology and evolution remain understudied. This review explores the costs flies impose on amphibians, such as pathogen transmission and disruption of communication systems, and highlights the evolutionary strategies employed by both ...
Leonardo Leite Ferraz de Campos, Luiz Carlos Pinho, Selvino Neckel‐Oliveira, Ximena E. Bernal   +3 more
wiley   +1 more source

Triage and care for women with symptoms or diagnosis of pregnancy loss between 14 + 0 and 21 + 6 weeks' gestation

International Journal of Gynecology &Obstetrics, Volume 172, Issue 1, Page 25-50, January 2026.
Abstract Mid‐trimester pregnancy loss (MTL), defined as a pregnancy loss occurring between 14 + 0 and 21 + 6 weeks of gestation, causes significant physical and emotional distress to women and presents clinical challenges to healthcare professionals. It is acknowledged that in low‐resource settings, this guideline might be applicable to births up to 28 
Caroline E. Fox, Rosinder Kaur, Kugajeevan Vigneswaran, Rachel Small, Jenny Carter, Keelin O'Donoghue, Alexander E. P. Heazell, Anna L. David, Nigel Simpson, Angharad Care, Lisa Starrs, Andrew Shennan, Catalina María Valencia González, Priya Soma‐Pillay, Leah Fitzsimmons, Adam J. Devall, Arri Coomarasamy, Mid‐trimester Pregnancy Loss Guideline Consensus Panel, Owen Arthurs, Ruth Bender‐Atik, Phil Bennett, Kirstien Boelaert, Elizabeth Bonney, Leanna Brace, Naomi Carlisle, Davide Casagrandi, Manju Chandiramani, Carolyn Chiswick, Alexandra Emms, Stella Fielder, James Goadsby, Laura Goodfellow, Jim Gray, Jemma Johns, Emma Kirk, Will Lester, Sophie Mackay, Maria Memtsa, Katie Morris, Sunbal Mukhtar, Naimah Raza, Rita Sarquis, Neil Sebire, Lucy Smith, Lucy Spencer, Amos Tetteh, Natalie Woodhead   +46 more
wiley   +1 more source

A proteomic view of the Plasmodium falciparum life cycle [PDF]

, 2002
Laurence Florens, Michael P. Washburn, Joshua Raine, Robert M. Anthony, Munira Grainger, J. David Haynes, J. Kathleen Moch, Nemone Muster, John B. Sacci, David L. Tabb, Adam A. Witney, Dirk Wolters, Yimin Wu, Malcolm J. Gardner, Anthony A. Holder, Robert E. Sinden, John R. Yates, Daniel J. Carucci   +17 more
openalex   +1 more source