Frontiers in Cellular and Infection Microbiology, 2022 Apicomplexan parasites transmitted by vectors, including Babesia spp. and Plasmodium spp., cause severe disease in both humans and animals. These parasites have a complex life cycle during which they migrate, invade, and replicate in contrasting hosts ...
Martina Soledad Paoletta +1 more
doaj +1 more source
Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach [PDF]
, 2019 We introduce an agent-based model describing a susceptible-infectious-susceptible (SIS) system of humans and mosquitoes to predict malaria epidemiological scenarios in realistic biological conditions.
Lind, Pedro G. +3 more
core +2 more sources
B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns
Advanced Science, EarlyView.B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang +16 more
wiley +1 more source
Predicting the direct and indirect impacts of climate change on malaria in coastal Kenya.
PLoS ONE, 2019 BACKGROUND:The transmission of malaria is highly variable and depends on a range of climatic and anthropogenic factors. This study investigates the combined, i.e.
Phong V V Le +4 more
doaj +1 more source
Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies
Microorganisms, 2023 Malaria elimination may never succeed without the implementation of transmission-blocking strategies. The transmission of Plasmodium spp. parasites from the human host to the mosquito vector depends on circulating gametocytes in the peripheral blood of ...
Dinkorma T. Ouologuem +4 more
doaj +1 more source
Evolving Gene Regulatory Networks with Mobile DNA Mechanisms
, 2013 This paper uses a recently presented abstract, tuneable Boolean regulatory network model extended to consider aspects of mobile DNA, such as transposons.
Adamatzky, Andrew, Bull, Larry
core +1 more source
Avian malaria co-infections confound infectivity and vector competence assays of Plasmodium homopolare. [PDF]
, 2018 Currently, there are very few studies of avian malaria that investigate relationships among the host-vector-parasite triad concomitantly. In the current study, we experimentally measured the vector competence of several Culex mosquitoes for a newly ...
Barker, Christopher M +5 more
core +1 more source
Advanced Science, EarlyView.ACE can modulate the CBL‐mediated K48 ubiquitination degradation of PSAP by altering its glycosylation levels in NP cells. As a result, NP cells secrete PSAP, which interacts with GPR37 on macrophage surfaces, facilitating their polarization toward the M2 phenotype. These M2 macrophages subsequently secrete TGFβ, which exerts feedback effects on the NP
Youfeng Guo +6 more
wiley +1 more source
Systems Biology and the Development of Vaccines and Drugs for Malaria Treatments [PDF]
, 2006 The sequencing race has ended and the functional race has already begun. Microarray technology enables simultaneous gene expression analysis of thousands of genes, enabling a snapshot of an organisms’ transcriptome at an unprecedented resolution.
Adebiyi, E. F.
core +1 more source
Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS) [PDF]
, 2012 Background: The pir genes comprise the largest multi-gene family in Plasmodium, with members found in P. vivax, P. knowlesi and the rodent malaria species.
Berriman, Matthew +11 more
core +3 more sources