Results 171 to 180 of about 530,210 (299)

Determinants of Malaria Vaccine Awareness Among Women in Ghana: Findings From the 2022 Ghana Malaria Indicator Survey

open access: yesPublic Health Challenges, Volume 4, Issue 4, December 2025.
Malaria vaccine awareness in Ghana is driven by education, digital access, age, religion, and region. Closing digital and regional gaps is essential to reach underserved women and support Ghana's malaria elimination goals. ABSTRACT Background In Ghana, pregnant women are disproportionately affected by malaria, yet awareness of malaria vaccination ...
Michael Sarfo   +4 more
wiley   +1 more source

PfSPATR, a Plasmodium falciparum Protein Containing an Altered Thrombospondin Type I Repeat Domain Is Expressed at Several Stages of the Parasite Life Cycle and Is the Target of Inhibitory Antibodies [PDF]

open access: hybrid, 2003
Rana Chattopadhyay   +10 more
openalex   +1 more source

Ligand binding Pro‐miscuity of acylpeptide hydrolase, structural analysis of a detoxifying serine hydrolase

open access: yesProtein Science, Volume 34, Issue 11, November 2025.
Abstract Acylpeptide hydrolase (APEH) or acylaminoacyl‐peptidase (AAP) is a serine hydrolase that regulates protein metabolism. It can also bind to and process unusual substrates, acting as a detoxifier. To better understand its promiscuous specificity, we determined the cryo‐EM structures of mammalian APEH complexed with classical serine protease ...
Anna J. Kiss‐Szemán   +8 more
wiley   +1 more source

Acute Plasmodium yoelii 17XNL Infection During BCG Vaccination Limits T Cell Responses and Mycobacterial Growth Inhibition

open access: yesImmunology, Volume 176, Issue 3, Page 373-384, November 2025.
Tuberculosis and malaria overlap in many sub‐Saharan African countries where BCG vaccination is routinely administered. The aim of this study was to determine whether the timing of BCG vaccination in relation to a malaria infection has implications for BCG vaccine efficacy.
Emily Tangie   +7 more
wiley   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang   +15 more
wiley   +1 more source

The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite [PDF]

open access: gold, 2009
Elyzana Putrianti   +5 more
openalex   +1 more source

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar   +15 more
wiley   +1 more source

One‐Pot Isothermal Nucleic Acid Amplification Assisted CRISPR/Cas Detection Technology: Challenges, Strategies, and Perspectives

open access: yesAdvanced Science, Volume 12, Issue 37, October 6, 2025.
This review combines the current status of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)‐based molecular diagnostic technology to expound the necessity and challenges faced in promoting the development of one‐pot detection. Besides, the focus is on a comprehensive summary and incisive analysis of emerging strategies for one‐pot ...
Hongyan Liu   +10 more
wiley   +1 more source

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