Results 41 to 50 of about 530,210 (299)

Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites

mBio, 2021
During its complex life cycle, the malaria parasite survives dramatic environmental stresses, including large temperature shifts.
Emily S. Mathews, Andrew J. Jezewski, Audrey R. Odom John   +2 more
doaj   +1 more source

Plasmodium Reproduction, Cell Size, and Transcription: How to Cope With Increasing DNA Content?

Frontiers in Cellular and Infection Microbiology, 2021
Plasmodium, the unicellular parasite that causes malaria, evolved a highly unusual mode of reproduction. During its complex life cycle, invasive or transmissive stages alternate with proliferating stages, where a single parasite can produce tens of ...
Marta Machado, Marta Machado, Salome Steinke, Markus Ganter   +3 more
doaj   +1 more source

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

eLife, 2020
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins ...
Aurélia C Balestra, Mohammad Zeeshan, Edward Rea, Carla Pasquarello, Lorenzo Brusini, Tobias Mourier, Amit Kumar Subudhi, Natacha Klages, Patrizia Arboit, Rajan Pandey, Declan Brady, Sue Vaughan, Anthony A Holder, Arnab Pain, David JP Ferguson, Alexandre Hainard, Rita Tewari, Mathieu Brochet   +17 more
doaj   +1 more source

The role of cGMP signalling in regulating life cycle progression of Plasmodium [PDF]

Microbes and Infection, 2012
The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and ...
Christine S. Hopp, Paul W. Bowyer, David A. Baker   +2 more
openalex   +4 more sources

Plasmodium yoelii yoelii 17XNL constitutively expressing GFP throughout the life cycle [PDF]

Experimental Parasitology, 2006
Plasmodium yoelii is a rodent parasite commonly used as a model to study malaria infection. It is the preferred model parasite for liver-stage immunological studies and is also widely used to study hepatocyte, erythrocyte and mosquito infection. We have generated a P.
Takeshi Ono, Takushi Tadakuma, Ana Rodrı́guez   +2 more
openalex   +3 more sources

Checks and balances? DNA replication and the cell cycle in Plasmodium

Parasites & Vectors, 2018
It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered, yet its intricacies remain incompletely understood - a knowledge gap that may prove crucial for our efforts to control the disease.
Holly Matthews, Craig W. Duffy, Catherine J. Merrick   +2 more
doaj   +1 more source

Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector

mBio, 2021
Gametocytes of the malaria parasite Plasmodium are taken up by the mosquito vector with an infectious blood meal, representing a critical stage for parasite transmission.
Sudhir Kumar, Meseret T. Haile, Michael R. Hoopmann, Linh T. Tran, Samantha A. Michaels, Seamus R. Morrone, Kayode K. Ojo, Laura M. Reynolds, Ulrike Kusebauch, Ashley M. Vaughan, Robert L. Moritz, Stefan H. I. Kappe, Kristian E. Swearingen   +12 more
doaj   +1 more source

Probing Plasmodium falciparum sexual commitment at the single-cell level [PDF]

, 2018
Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure.
Birren, Bruce W., Brancucci, Nicolas M.B., De Niz, Mariana, Marti, Matthias, Neafsey, Daniel E., Ravel, Deepali, Sollelis, Lauriane, Straub, Timothy J., Voss, Till S.   +8 more
core   +4 more sources

Ecology: a prerequisite for malaria elimination and eradication [PDF]

, 2010
* Existing front-line vector control measures, such as insecticide-treated nets and residual sprays, cannot break the transmission cycle of Plasmodium falciparum in the most intensely endemic parts of Africa and the Pacific * The goal of malaria ...
A Bhattarai, A Kiszewski, A Saul, Anna Dornhaus, Arlyne Beeche, AY Vittor, BL Sharp, C Garrett-Jones, C Lengeler, Christian Borgemeister, CR Rodriguez-Saona, D Fish, DL Smith, DL Smith, Durland Fish, EJ Scholte, EO Lyimo, EP Odum, FO Okumu, G Giglioli, G MacDonald, G Müller, G Müller, G Zhou, Gerry F. Killeen, GF Killeen, GF Killeen, GF Killeen, GJ Devine, GJ Yang, GP Garcia, GW Fegan, H Briegel, H Mshinda, H Pates, H Ranson, H Townson, HD Trung, Heather M. Ferguson, HM Ferguson, HM Ferguson, I Bates, I Bates, I Tirados, IN Lyimo, J Cox-Singh, J Keiser, J Keiser, JA Najera, JA Patz, JA Patz, JC Beier, John E. Gimnig, JP Grieco, L Kelly-Hope, L Molineaux, L Roberts, M Coluzzi, M Rowland, MA Riehle, Michael Gottlieb, Mir S. Mulla, MJ Kirby, MN Bayoh, MT Gillies, MT Gillies, MT Gillies, NJ Govella, R Feachem, RL Kouznetsov, SJ Ceesay, TW Scott, U Fillinger, W Gu, W Gu, W Gu, WA Hawley, WP O'Meara, Y Geissbuhler   +78 more
core   +4 more sources

Systems analysis of host-parasite interactions. [PDF]

, 2015
Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide.
Jamshidi, Neema, Lewis, Nathan E, Swann, Justine, Winzeler, Elizabeth A   +3 more
core   +1 more source