Results 61 to 70 of about 530,210 (299)

An evolutionary perspective on the kinome of malaria parasites [PDF]

, 2012
Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin, Carvalho T. G., Christian Doerig, Eric Talevich, Natarajan Kannan, Wells T. N., Wilson R. J.   +6 more
core   +1 more source

Structural Insights Into Key Plasmodium Proteases as Therapeutic Drug Targets

Frontiers in Microbiology, 2019
Malaria, caused by protozoan of genus Plasmodium, remains one of the highest mortality infectious diseases. Malaria parasites have a complex life cycle, easily adapt to their host’s immune system and have evolved with an arsenal of unique proteases which
Manasi Mishra, Vigyasa Singh, Shailja Singh, Shailja Singh   +3 more
doaj   +1 more source

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]

, 2014
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P., Billker, Oliver, Creek, Darren J., Limenitakis, Julien, Macrae, James I., McConville, Malcolm J., Modrzynska, Katarzyna K., Oppenheim, Rebecca D., Pino, Paco, Polonais, Valerie, Seeber, Frank, Soldati-Favre, Dominique   +11 more
core   +1 more source

The Malaria Cell Atlas: a comprehensive reference of single parasite transcriptomes across the complete Plasmodium life cycle

bioRxiv, 2019
Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments.
Virginia M. Howick, Andrew J. C. Russell, T. Andrews, Haynes Heaton, A. Reid, K. Natarajan, Hellen Butungi, Tom Metcalf, Lisa H. Verzier, J. Rayner, M. Berriman, J. Herren, O. Billker, M. Hemberg, A. Talman, M. Lawniczak   +15 more
semanticscholar   +1 more source

MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life

Cells, 2020
The meiotic recombination 11 protein (MRE11) plays a key role in DNA damage response and maintenance of genome stability. However, little is known about its function during development of the malaria parasite Plasmodium.
David S. Guttery, Abhinay Ramaprasad, David J. P. Ferguson, Mohammad Zeeshan, Rajan Pandey, Declan Brady, Anthony A. Holder, Arnab Pain, Rita Tewari   +8 more
doaj   +1 more source

Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility

Journal of Biological Chemistry, 2017
Myosin A (MyoA) is a Class XIV myosin implicated in gliding motility and host cell and tissue invasion by malaria parasites. MyoA is part of a membrane-associated protein complex called the glideosome, which is essential for parasite motility and ...
Judith L. Green, Richard J. Wall, J. Vahokoski, N. A. Yusuf, M. A. M. Ridzuan, Rebecca R. Stanway, J. Stock, E. Knuepfer, D. Brady, S. Martin, S. Howell, Isa Pires, R. Moon, J. Molloy, I. Kursula, R. Tewari, A. Holder   +16 more
semanticscholar   +1 more source

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

The role of the liver in the migration of parasites of global significance

Parasites & Vectors, 2019
Many parasites migrate through different tissues during their life-cycle, possibly with the aim to enhance their fitness. This is true for species of three parasite genera of global importance, Ascaris, Schistosoma and Plasmodium, which cause significant
Gwendoline Deslyper, Derek G. Doherty, James C. Carolan, Celia V. Holland   +3 more
doaj   +1 more source

Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy

Frontiers in Cellular and Infection Microbiology, 2021
Malaria is a parasitic disease that represents a public health problem worldwide. Protozoans of the Plasmodium genus are responsible for causing malaria in humans.
Daffiny Sumam de Oliveira, Thales Kronenberger, Giuseppe Palmisano, Carsten Wrenger, Edmarcia Elisa de Souza   +4 more
doaj   +1 more source

DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum. [PDF]

, 2014
BackgroundIn eukaryotic organisms, packaging of DNA into nucleosomes controls gene expression by regulating access of the promoter to transcription factors.
Bunnik, Evelien M, Gill, Sarjeet S, Le Roch, Karine G, Lonardi, Stefano, Polishko, Anton, Ponts, Nadia, Prudhomme, Jacques   +6 more
core   +3 more sources