Results 71 to 80 of about 530,210 (299)

Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis

Scientific Reports, 2018
The anaphase promoting complex/cyclosome (APC/C) is a highly conserved multi-subunit E3 ubiquitin ligase that controls mitotic division in eukaryotic cells by tagging cell cycle regulators for proteolysis.
Richard J. Wall, David J. P. Ferguson, Aline Freville, Blandine Franke-Fayard, Declan Brady, Mohammad Zeeshan, Andrew R. Bottrill, Sally Wheatley, Andrew M. Fry, Chris J. Janse, Hiroyuki Yamano, Anthony A. Holder, David S. Guttery, Rita Tewari   +13 more
doaj   +1 more source

Artemisinin resistance in P. falciparum: probing the interacting partners of Kelch13 protein in parasite

Journal of Global Antimicrobial Resistance, 2023
: Objectives: Artemisinin (ART) resistance in Plasmodium is threatening the artemisinin combination therapies—the first line of defence against malaria. ART resistance has been established to be mediated by the Plasmodium Kelch13 (PfK13) protein.
Atul, Preeti Chaudhary, Swati Gupta, Rumaisha Shoaib, Rahul Pasupureddy, Bharti Goyal, Bhumika Kumar, Om Prakash Singh, Rajnikant Dixit, Shailja Singh, Mymoona Akhter, Neera Kapoor, Veena Pande, Soumyananda Chakraborti, Kapil Vashisht, Kailash C. Pandey   +15 more
doaj   +1 more source

Long-term pathogenic response to Plasmodium relictum infection in Culex pipiens mosquito. [PDF]

PLoS ONE, 2018
The transmission of Plasmodium within a vertebrate host population is strongly associated with the life history traits of its vector. Therefore the effect of malaria infection on mosquito fecundity and longevity has traditionally received a lot of ...
Romain Pigeault, Manon Villa
doaj   +1 more source

Knockout studies reveal an important role of plasmodium lipoic acid protein ligase a1 for asexual blood stage parasite survival [PDF]

, 2009
Lipoic acid (LA) is a dithiol-containing cofactor that is essential for the function of a-keto acid dehydrogenase complexes. LA acts as a reversible acyl group acceptor and 'swinging arm' during acyl-coenzyme A formation.
A Witkowski, BJ Foth, BP Mooney, BS Crabb, C Lambros, C Wrenger, CJ Janse, CJ Tonkin, J Mazumdar, J Sambrook, J Umlas, JE Cronan, JL Stephens, Kai Matuschewski, KG Le Roch, KM Keeney, Lisa F. P. Ng, LJ Reed, M Allary, M O'Riordan, MB Reed, MJ Crawford, MM Bradford, N Thomsen-Zieger, PJ McMillan, R Douce, R Yasuno, RN Perham, S Günther, S Günther, S Günther, Svenja Günther, Sylke Müller, V Gueguen, V Thathy, W Trager, Y Wu, Y Wu   +37 more
core   +3 more sources

Label-free microfluidic enrichment of ring-stage Plasmodium falciparum-infected red blood cells using non-inertial hydrodynamic lift [PDF]

, 2014
<b>Background</b> Understanding of malaria pathogenesis caused by Plasmodium falciparum has been greatly deepened since the introduction of in vitro culture system, but the lack of a method to enrich ring-stage parasites remains a technical ...
Chan, Sherwin, Franke, Thomas, Geislinger, Thomas M, Moll, Kirsten, Wahlgren, Mats, Wixforth, Achim   +5 more
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development. [PDF]

, 2014
BACKGROUND: Gametocytes are the Plasmodium life stage that is solely responsible for malaria transmission. Despite their important role in perpetuating malaria, gametocyte differentiation and development is poorly understood.
Delves, MJ, Lamour, SD, Saric, J, Straschil, U   +3 more
core   +3 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Live imaging of the Cryptosporidium parvum life cycle reveals direct development of male and female gametes from type I meronts

PLoS Biology, 2022
Cryptosporidium is a leading infectious cause of diarrhea around the world associated with waterborne outbreaks, community spread, or zoonotic transmission.
Elizabeth D. English, Amandine Guérin, Jayesh Tandel, B. Striepen   +3 more
semanticscholar   +1 more source

Dendritic cells in plasmodium infection [PDF]

, 2008
Infection with Plasmodium parasites (malaria) contributes greatly to morbidity and mortality in affected areas. Interaction of the protozoan with the immune system has a critical role in the pathogenesis of the disease, but may also hold a key to ...
Alonso, Bejon, Britta C Urban, Bruna-Romero, deWalick, Greenwood, Park, Patel, Perry, Pichyangkul, Pouniotis, Skorokhod, Stephen M Todryk, Todryk, Wong, Wykes   +15 more
core   +2 more sources