Results 1 to 10 of about 1,478,804 (377)

The Role of BDNF on Neural Plasticity in Depression [PDF]

Frontiers in Cellular Neuroscience, 2020
Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala ...
Tao Yang, Zheng Nie, Haifeng Shu, Yong-qin Kuang, Xin Chen, Jingmin Cheng, Sixun Yu, Huiying Liu   +7 more
openalex   +2 more sources

Top-down inputs enhance orientation selectivity in neurons of the primary visual cortex during perceptual learning. [PDF]

, 2014
Perceptual learning has been used to probe the mechanisms of cortical plasticity in the adult brain. Feedback projections are ubiquitous in the cortex, but little is known about their role in cortical plasticity.
Bazhenov, Maxim, Moldakarimov, Samat, Sejnowski, Terrence J   +2 more
core   +17 more sources

Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies

Signal Transduction and Targeted Therapy, 2023
Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via phenotypic switching driven by intrinsic or induced cell plasticity ...
Zhenjun Shi, K. Pang, Zhuoxun Wu, Yang Dong, Lin Hao, Jia-Xin Qin, Wen Wang, Zhe‐Sheng Chen, Cong Han   +8 more
semanticscholar   +1 more source

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

iScience, 2021
Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4 ...
Jithin D. Nair, Ellen Braksator, Busra P. Yucel, Alexandra Fletcher-Jones, Richard Seager, Jack R. Mellor, Zafar I. Bashir, Kevin A. Wilkinson, Jeremy M. Henley   +8 more
doaj   +1 more source

Plasticity, plasticity, plasticity…and the rigid problem of sex [PDF]

Trends in Cognitive Sciences, 2013
Why is popular understanding of female–male differences still based on rigid models of development, even though contemporary developmental sciences emphasize plasticity? Is it because the science of sex differences still works from the same rigid models?
Fine, Cordelia, Jordan-Young, Rebecca, Kaiser, Anelis C., Rippon, Gina   +3 more
openaire   +3 more sources

Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling

Science, 2022
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage
J. Chan, S. Zaidi, J. Love, Jimmy L. Zhao, M. Setty, K. Wadosky, A. Gopalan, Z. Choo, S. Persad, Jungmin Choi, Justin Laclair, K. Lawrence, O. Chaudhary, Tianhao Xu, I. Masilionis, I. Linkov, Shangqian Wang, Cindy J Lee, A. Barlas, M. Morris, L. Mazutis, R. Chaligné, Yu Chen, D. Goodrich, W. Karthaus, D. Pe’er, C. Sawyers   +26 more
semanticscholar   +1 more source

Online conversion of reconstructed neural morphologies into standardized SWC format

Nature Communications, 2023
Digital reconstructions provide an accurate and reliable way to store, share, model, quantify, and analyze neural morphology. Continuous advances in cellular labeling, tissue processing, microscopic imaging, and automated tracing catalyzed a ...
Ketan Mehta, Bengt Ljungquist, James Ogden, Sumit Nanda, Ruben G. Ascoli, Lydia Ng, Giorgio A. Ascoli   +6 more
doaj   +1 more source

Plasticity and dystonia: a hypothesis shrouded in variability. [PDF]

, 2020
Studying plasticity mechanisms with Professor John Rothwell was a shared highlight of our careers. In this article, we discuss non-invasive brain stimulation techniques which aim to induce and quantify plasticity, the mechanisms and nature of their ...
A Albanese, A Berardelli, A Conte, A Guerra, A Guerra, A Karabanov, A Karabanov, A Latorre, A Quartarone, A Quartarone, A Quartarone, A Quartarone, A Quartarone, A Quartarone, A Sadnicka, A Sadnicka, A Sadnicka, Anna Sadnicka, B Balint, B Cheeran, B Hordacre, C Ganos, C Terranova, D Belvisi, D Weise, F Fratello, F Pierelli, G Abbruzzese, H Eggink, HA Jinnah, HR Siebner, JF Muller-Dahlhaus, JS Kang, K Stefan, KM Fedak, KP Bhatia, L Ozelius, M Hamada, M Hamada, M Kojovic, M Pellegrini, Masashi Hamada, MC Ridding, N Patel, NH Jung, RG Carson, S Meunier, S Wiethoff, SA Schneider, V Lopez-Alonso, V Lopez-Alonso, YZ Huang, YZ Huang   +52 more
core   +1 more source

The Bergen 4-day treatment for panic disorder: adapting to COVID-19 restrictions with a hybrid approach of face-to-face and videoconference modalities

BMC Psychiatry, 2023
Background The Bergen 4-day treatment (B4DT) is a concentrated exposure-based therapy that has been shown to be effective in the treatment of anxiety disorders.
Kay Morten Hjelle, Thorstein Olsen Eide, Anders Lillevik Thorsen, Gerd Kvale, Kristen Hagen, Ivar Snorrason, Thröstur Björgvinsson, Bjarne Hansen   +7 more
doaj   +1 more source

Changes in pallidal neural activity following long-term symptom improvement from botulinum toxin treatment in DYT6 dystonia: a case report

Journal of Medical Case Reports, 2022
Background The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable.
Andrea Giorni, Terry Coyne, Peter A. Silburn, George D. Mellick, Pankaj Sah, François Windels   +5 more
doaj   +1 more source