Results 1 to 10 of about 485,193 (289)
Journal of Neuroinflammation, 2020 Background Early-life stress (ES) is an emerging risk factor for later life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 mouse model ...
Maralinde R. Abbink +7 more
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Structure and size of the plastic zone formed during nanoindentation of a metallic glass [PDF]
Journal of Non-Crystalline Solids, Volume 523, (2019), 119593, 2019 Using molecular dynamics simulation, we study the plastic zone created during nanoindentation of a large CuZr glass system. The plastic zone consists of a core region, in which virtually every atom undergoes plastic rearrangement, and a tail, where the density distribution of the plastically active atoms decays to zero.
arxiv +1 more source
iScience, 2021 Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4 ...
Jithin D. Nair +8 more
doaj
Deep Reinforcement Learning with Plasticity Injection [PDF]
arXiv, 2023 A growing body of evidence suggests that neural networks employed in deep reinforcement learning (RL) gradually lose their plasticity, the ability to learn from new data; however, the analysis and mitigation of this phenomenon is hampered by the complex relationship between plasticity, exploration, and performance in RL.
arxiv
Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth
eLife, 2014 Endocannabinoids are recently recognized regulators of brain development, but molecular effectors downstream of type-1 cannabinoid receptor (CB1R)-activation remain incompletely understood.
Alexandre B Roland +10 more
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Ancestral glycoprotein hormone-receptor pathway controls growth in C. elegans
Frontiers in Endocrinology, 2023 In vertebrates, thyrostimulin is a highly conserved glycoprotein hormone that, besides thyroid stimulating hormone (TSH), is a potent ligand of the TSH receptor.
Signe Kenis +6 more
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Nature Communications, 2021 Combining optogenetics, behavioral modelling and neural population analysis, the authors show in mice that during fear-related freezing the olfactory bulb transmits 4 Hz breathing rhythm to the prefrontal cortex where this oscillation organizes local ...
Sophie Bagur +8 more
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Mode I crack tip fields: strain gradient plasticity theory versus J2 flow theory [PDF]
European Journal of Mechanics A/Solids (2019), 2019 The mode I crack tip asymptotic response of a solid characterised by strain gradient plasticity is investigated. It is found that elastic strains dominate plastic strains near the crack tip, and thus the Cauchy stress and the strain state are given asymptotically by the elastic K-field.
arxiv +1 more source
eLife, 2019 Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear.
Alexandra Fletcher-Jones +5 more
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Ice : The paradigm of wild plasticity [PDF]
, 2019 Ice plasticity has been thoroughly studied, owing to its importance in glaciers and ice sheets dynamics. In particular, its anisotropy (easy basal slip) has been suspected for a long time, then fully characterized 40 years ago. More recently emerged the interest of ice as a model material to study some fundamental aspects of crystalline plasticity.
arxiv +1 more source