Results 1 to 10 of about 808,635 (344)

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance.

open access: yesCell Stem Cell, 2019
Our traditional understanding of phenotypic plasticity in adult somatic cells comprises dedifferentiation and transdifferentiation in the context of tissue regeneration or wound healing. Although dedifferentiation is central to tissue repair and stemness,
Piyush B. Gupta   +4 more
semanticscholar   +1 more source

NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor

open access: yesScientific Reports, 2018
NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. In this study we investigate and compare the structures and functions of these FnIII domains. The NCAM1 and -2 FnIII2 domains both contain a Walker
Kim Krighaar Rasmussen   +13 more
doaj   +1 more source

Predictive modelling for enhanced scratching of brittle ceramics with magneto-plasticity

open access: hybrid, 2023
Yunfa Guo   +4 more
openalex   +1 more source

The AMPA Receptor Code of Synaptic Plasticity

open access: yesNeuron, 2018
Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors (AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including long-term potentiation (LTP), long-term depression (LTD), and homeostatic ...
Graham H. Diering, R. Huganir
semanticscholar   +1 more source

Improved Acuity and Dexterity but Unchanged Touch and Pain Thresholds following Repetitive Sensory Stimulation of the Fingers

open access: yesNeural Plasticity, 2012
Neuroplasticity underlies the brain’s ability to alter perception and behavior through training, practice, or simply exposure to sensory stimulation.
Rebecca Kowalewski   +3 more
doaj   +1 more source

Diversified glucosinolate metabolism: biosynthesis of hydrogen cyanide and of the hydroxynitrile glucoside alliarinoside in relation to sinigrin metabolism in Alliaria petiolata

open access: yesFrontiers in Plant Science, 2015
Alliaria petiolata (garlic mustard, Brassicaceae) contains the glucosinolate sinigrin as well as alliarinoside, a γ-hydroxynitrile glucoside structurally related to cyanogenic glucosides.
Tina eFrisch   +16 more
doaj   +1 more source

PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation

open access: yeseLife
Relevance-based selectivity and high energy cost are two distinct features of long-term memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a highly conserved cognitive mechanism that can lift this inhibition ...
Typhaine Comyn   +3 more
doaj   +1 more source

Macrophages in wound healing: activation and plasticity

open access: yesImmunology and Cell Biology, 2019
Macrophages are critically involved in wound healing, from dampening inflammation to clearing cell debris and coordinating tissue repair. Within the wound, the complexity of macrophage function is increasingly recognized, with adverse outcomes when ...
Sang Yong Kim, M. Nair
semanticscholar   +1 more source

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