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Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies [PDF]
Signal Transduction and Targeted Therapy, 2023 Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via phenotypic switching driven by intrinsic or induced cell plasticity ...
Zhenduo Shi +8 more
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iScience, 2021 Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4 ...
Jithin D. Nair +8 more
doaj +1 more source
Online conversion of reconstructed neural morphologies into standardized SWC format
Nature Communications, 2023 Digital reconstructions provide an accurate and reliable way to store, share, model, quantify, and analyze neural morphology. Continuous advances in cellular labeling, tissue processing, microscopic imaging, and automated tracing catalyzed a ...
Ketan Mehta +6 more
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Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Science, 2022 Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage
J. Chan +26 more
semanticscholar +1 more source
BMC Psychiatry, 2023 Background The Bergen 4-day treatment (B4DT) is a concentrated exposure-based therapy that has been shown to be effective in the treatment of anxiety disorders.
Kay Morten Hjelle +7 more
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Diversity, Mechanisms, and Significance of Macrophage Plasticity.
Annual Review of Pathology, 2020 Macrophages are a diverse set of cells present in all body compartments. This diversity is imprinted by their ontogenetic origin (embryonal versus adult bone marrow-derived cells); the organ context; the activation or deactivation of various signals in ...
M. Locati, G. Curtale, A. Mantovani
semanticscholar +1 more source
Journal of Medical Case Reports, 2022 Background The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable.
Andrea Giorni +5 more
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Communications Biology, 2023 Curiosity, or novelty seeking, is a fundamental mechanism motivating animals to explore and exploit environments to improve survival, and is also positively associated with cognitive, intrapersonal and interpersonal well-being in humans.
Qiang Shan +4 more
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Crystals, 2021 The Special Issue on “Crystal Plasticity” is a collection of 25 original articles (including one review paper) dedicated to theoretical and experimental research works providing new insights and practical findings in the field of crystal plasticity ...
W. Polkowski
semanticscholar +1 more source
Physical but not virtual presence of others potentiates implicit and explicit learning
Scientific Reports, 2022 E-learning activities are becoming more and more common. Whilst it is well known that the physical presence of others motivates individuals to engage in perceptual and learning tasks, systematic investigations comparing the effects of physical and ...
Pietro Sarasso +8 more
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