Results 31 to 40 of about 1,145,160 (280)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Nature Communications, 2021 Combining optogenetics, behavioral modelling and neural population analysis, the authors show in mice that during fear-related freezing the olfactory bulb transmits 4 Hz breathing rhythm to the prefrontal cortex where this oscillation organizes local ...
Sophie Bagur +8 more
doaj +1 more source
Ancestral glycoprotein hormone-receptor pathway controls growth in C. elegans
Frontiers in Endocrinology, 2023 In vertebrates, thyrostimulin is a highly conserved glycoprotein hormone that, besides thyroid stimulating hormone (TSH), is a potent ligand of the TSH receptor.
Signe Kenis +6 more
doaj +1 more source
Nanoindentation and incipient plasticity [PDF]
, 1999 This paper presents a large-scale atomic resolution simulation of nanoindentation into a thin aluminum film using the recently introduced quasicontinuum method.
Miller, R. +3 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
eLife, 2019 Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear.
Alexandra Fletcher-Jones +5 more
doaj +1 more source
Hot ductility of TiNb IF steel slab after hot torsion testing [PDF]
, 2019 The aim of the work was to evaluate the hot ductility loss in TiNb stabilized IF steel directly from the continuously-cast slab using hot torsion testing (plastometry) in the temperature range 600-1250 degrees C according to the basic programme, and also
Bořuta, Aleš +10 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Translational Psychiatry, 2022 Attention-deficit/hyperactivity disorder (ADHD) is a common and debilitating neurodevelopmental disorder associated with various negative life impacts.
Sabine Dziemian +2 more
doaj +1 more source