Results 31 to 40 of about 530,147 (296)

Social maintenance masks induced aggression in zebrafish

Scientific Reports
Animal behavior is dynamically shaped by internal states and external social contexts. This study examines how internal states and social buffering influence aggression and social behavior.
Ashil Arroth Kuniyil, Muhammed Sinan Malik, Rahul Kizhakke Vellattu, Dhanusha Sivarajan, Gokul Krishna Thozhukkara Mannarapurayil, Fasna Pokkakillath Faisal, Nimisha Chathooth, Binu Ramachandran   +7 more
doaj   +1 more source

Somatosensory alpha oscillations gate perceptual learning efficiency

Nature Communications, 2019
Alpha power is known to play an important role in cognition and perception, but we do not understand the link between alpha power and perceptual learning efficacy.
Marion Brickwedde, Marie C. Krüger, Hubert R. Dinse   +2 more
doaj   +1 more source

LRP4 is required for the olfactory association task in the piriform cortex

Cell & Bioscience, 2022
Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long ...
Min Yan, Mingtao Xiong, Yongqiang Wu, Dong Lin, Peng Chen, Jiang Chen, Ziyang Liu, Hang Zhang, Dongyan Ren, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang   +12 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Brief treatments for panic disorder: a pilot study of the bergen repeated one-session treatment format

BMC Psychiatry
Background Panic disorder (PD) significantly impacts individuals’ daily lives and overall well-being. While cognitive behavioral therapy (CBT) is the gold standard for PD treatment, there is a growing interest in brief interventions to improve ...
Bjarne Hansen, Kay Morten Hjelle, Thröstur Björgvinsson, Olav Erland, Kristen Hagen   +4 more
doaj   +1 more source

Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson’s Disease from Mice to Human

Biomedicines, 2023
The enteric nervous system (ENS) is a nerve network composed of neurons and glial cells that regulates the motor and secretory functions of the gastrointestinal (GI) tract.
Martina Montanari, Paola Imbriani, Paola Bonsi, Giuseppina Martella, Antonella Peppe   +4 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Long-term follow-up of the Bergen 4-day treatment for panic disorder during the COVID-19 pandemic

Cogent Psychology
The COVID-19 pandemic has necessitated essential modifications to the administration of psychotherapy for patients with panic disorder (PD) through the increased use of videoconferencing.
Kay Morten Hjelle, Thorstein Olsen Eide, Anders Lillevik Thorsen, Gerd Kvale, Kristen Hagen, Michael G. Wheaton, Thröstur Björgvinsson, Bjarne Hansen   +7 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Combining genotypic and phenotypic analyses on single mutant zebrafish larvae

MethodsX, 2018
Zebrafish is a powerful animal model used to study vertebrate embryogenesis, organ development and diseases (Gut et al., 2017) [1]. The usefulness of the model was established as a result of various large forward genetic screens identifying mutants in ...
Barbara Dupret, Pamela Völkel, Pauline Follet, Xuefen Le Bourhis, Pierre-Olivier Angrand   +4 more
doaj   +1 more source