Results 191 to 200 of about 42,889 (307)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Chloroplast Fibrillin‐Mediated α‐Tocopherol Biosynthesis Impaired by a Virus to Enhance Infection and to Improve Drought Tolerance

open access: yesAdvanced Science, Volume 13, Issue 3, 14 January 2026.
ToCV‐encoded p22 targets chloroplast plastoglobules (PGs) via directly binding PG structural protein FBN1.1, reducing the size of PG and inhibiting α‐tocopherol biosynthesis via competing with tocopherol cyclase (VTE1). Consequently, the elevated chloroplast ROS not only creates a suitable cellular environment for efficient ToCV infection but also ...
Sijia Liu   +8 more
wiley   +1 more source

Genome‐scale Metabolic Modeling Guided Escherichia coli Engineering for De Novo Biosynthesis of Chrysanthemic Acid

open access: yesAdvanced Science, Volume 13, Issue 2, 9 January 2026.
Genome‐scale metabolic modeling is preceded to the engineered E. coli cell factory for the de novo biosynthesis of biopesticide chrysanthemic acid. The debranching strategy redirects metabolic flux, enhancing precursor and target compound production.
Jiangpeng Yu   +6 more
wiley   +1 more source

Optimized Laboratory Maintenance and Functional Testing of Chara braunii

open access: yesCurrent Protocols, Volume 6, Issue 1, January 2026.
Abstract Chara braunii is an emerging model species for studying plant evolution and development. Various members of the Chara genus have been used for pioneering studies of electrophysiology, cytoplasmic streaming, and cell biology. However, many studies have been limited by challenges, such as overgrowth with epiphytes or non‐continuous growth ...
Katarina Kurtović   +2 more
wiley   +1 more source

Phylogenetic position of Toxarium, within the diatoms (Bacillariophyceae) [PDF]

open access: yes, 2003
DeStefano, M.   +4 more
core  

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