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The Platelet Lifeline to Cancer: Challenges and Opportunities
Cancer Cell, 2018 Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis.
Monika Haemmerle +2 more
exaly +2 more sources
Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicity
eLife, 2022 Background: Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. Existence of functional Notch signaling in enucleate platelets remains elusive.
Susheel N Chaurasia +5 more
doaj +1 more source
Life, 2023 EVs are membranous subcellular structures originating from various cells, including platelets which consist of biomolecules that can modify the target cell’s pathophysiological functions including inflammation, cell communication, coagulation, and ...
Preeti Kumari Chaudhary +2 more
doaj +1 more source
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
Journal of Hematology & Oncology, 2020 Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events ...
Shenmin Zhang +16 more
semanticscholar +1 more source
Platelet‐to‐lymphocyte ratio is associated with prognosis in patients with coronavirus disease‐19
Journal of Medical Virology, 2020 Since December 2019, novel coronavirus infected pneumonia emerged in Wuhan city and rapidly spread throughout China. In severe novel coronavirus pneumonia cases, the number of platelets, their dynamic changes during the treatment, platelet‐to‐lymphocyte ...
Rong Qu +10 more
semanticscholar +1 more source
Animals, 2023 Glucocorticoids have been commonly used in the treatment of inflammation and immune-mediated diseases in human beings and small animals such as cats and dogs.
Sanggu Kim +2 more
doaj +1 more source
An Insight into GPCR and G-Proteins as Cancer Drivers
Cells, 2021 G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling receptors known to play a crucial role in various physiological functions, including tumor growth and metastasis.
Preeti Kumari Chaudhary, Soochong Kim
doaj +1 more source
Arteriosclerosis, 2020 Platelets are discoidal cytoplasmic particles that respond to a variety of stimuli by developing filopodia and rounding up (shape change), developing the ability to bind fibrinogen from the medium, and, with strong stimuli such as thrombin and PAF ...
Marjorie B. Zucker, V. Nachmias
semanticscholar +1 more source
Platelet-rich plasma: Growth factor enhancement for bone grafts.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1998 Platelet-rich plasma is an autologous source of platelet-derived growth factor and transforming growth factor beta that is obtained by sequestering and concentrating platelets by gradient density centrifugation. This technique produced a concentration of
R. Marx +6 more
semanticscholar +1 more source