Results 1 to 10 of about 32,510 (75)

Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicity

open access: yeseLife, 2022
Background: Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. Existence of functional Notch signaling in enucleate platelets remains elusive.
Susheel N Chaurasia   +5 more
doaj   +1 more source

Shedding Light on the Cell Biology of Platelet-Derived Extracellular Vesicles and Their Biomedical Applications

open access: yesLife, 2023
EVs are membranous subcellular structures originating from various cells, including platelets which consist of biomolecules that can modify the target cell’s pathophysiological functions including inflammation, cell communication, coagulation, and ...
Preeti Kumari Chaudhary   +2 more
doaj   +1 more source

Role of Prednisolone in Platelet Activation by Inhibiting TxA2 Generation through the Regulation of cPLA2 Phosphorylation

open access: yesAnimals, 2023
Glucocorticoids have been commonly used in the treatment of inflammation and immune-mediated diseases in human beings and small animals such as cats and dogs.
Sanggu Kim   +2 more
doaj   +1 more source

An Insight into GPCR and G-Proteins as Cancer Drivers

open access: yesCells, 2021
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling receptors known to play a crucial role in various physiological functions, including tumor growth and metastasis.
Preeti Kumari Chaudhary, Soochong Kim
doaj   +1 more source

Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile

open access: yesFrontiers in Cardiovascular Medicine, 2022
BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li   +15 more
doaj   +1 more source

Immersed boundary simulations of cell-cell interactions in whole blood [PDF]

open access: yes, 2021
We present a new method for the geometric reconstruction of elastic surfaces simulated by the immersed boundary method with the goal of simulating the motion and interactions of cells in whole blood. Our method uses parameter-free radial basis functions for high-order meshless parametric reconstruction of point clouds and the elastic force computations
arxiv   +1 more source

Glycoprotein Ib clustering in platelets can be inhibited by α-linolenic acid as revealed by cryo-electron tomography

open access: yesHaematologica, 2020
Platelet adhesion to the sub-endothelial matrix and damaged endothelium occurs through a multi-step process mediated in the initial phase by glycoprotein Ib binding to von Willebrand factor (vWF), which leads to the subsequent formation of a platelet ...
Simona Stivala   +7 more
doaj   +1 more source

Rupture Forces among Human Blood Platelets at different Degrees of Activation [PDF]

open access: yes, 2020
Little is known about mechanics underlying the interaction among platelets during activation and aggregation. Although the strength of a blood thrombus has likely major biological importance, no previous study has measured directly the adhesion forces of single platelet-platelet interaction at different activation states.
arxiv   +1 more source

In silico analysis of Glanzmann variants of Calf-1 domain of αIIbβ3 integrin revealed dynamic allosteric effect

open access: yesScientific Reports, 2017
Integrin αIIbβ3 mediates platelet aggregation and thrombus formation. In a rare hereditary bleeding disorder, Glanzmann thrombasthenia (GT), αIIbβ3 expression / function are impaired.
Matthieu Goguet   +4 more
doaj   +1 more source

Refinement of a mouse cardiovascular model: Development, application and dissemination [version 1; referees: 2 approved, 1 approved with reservations]

open access: yesF1000Research, 2018
European and UK legislation requires all animal procedures to be conducted with consideration to reduction, refinement and replacement. In this review, 3Rs developments are discussed in the field of platelet biology and thromboembolism. Platelet research
Kirk A. Taylor, Michael Emerson
doaj   +1 more source

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