Results 1 to 10 of about 1,217,034 (357)

Casein kinase I isoforms contribute to platelet activation and thrombogenesis via RIPK3–MLKL signaling [PDF]

Communications Biology
Platelets are small, enucleate blood cells having life span of 10-12 days that play fundamental role in hemostasis and thrombosis. Casein Kinase 1 (CK1) is a serine/threonine-specific protein kinase that governs multiple cellular processes including ...
Vipin Singh, Mohammad Ekhlak, Susheel N. Chaurasia, Debabrata Dash   +3 more
doaj   +2 more sources

Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicity

eLife, 2022
Background: Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. Existence of functional Notch signaling in enucleate platelets remains elusive.
Susheel N Chaurasia, Mohammad Ekhlak, Geeta Kushwaha, Vipin Singh, Ram L Mallick, Debabrata Dash   +5 more
doaj   +1 more source

Shedding Light on the Cell Biology of Platelet-Derived Extracellular Vesicles and Their Biomedical Applications

Life, 2023
EVs are membranous subcellular structures originating from various cells, including platelets which consist of biomolecules that can modify the target cell’s pathophysiological functions including inflammation, cell communication, coagulation, and ...
Preeti Kumari Chaudhary, Sanggu Kim, Soochong Kim   +2 more
doaj   +1 more source

Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing. [PDF]

, 2020
Platelets are a recognised potent source of transforming growth factor-β1 (TGFβ1), a cytokine known to promote wound healing and regeneration by stimulating dermal fibroblast proliferation and extracellular matrix deposition.
Chong, DLW, Holmes, AM, Hughes, S, Labelle, M, Porter, JC, Rodriguez-Justo, M, Scotton, CJ, Trinder, S   +7 more
core   +3 more sources

Role of Prednisolone in Platelet Activation by Inhibiting TxA₂ Generation through the Regulation of cPLA₂ Phosphorylation

Animals, 2023
Glucocorticoids have been commonly used in the treatment of inflammation and immune-mediated diseases in human beings and small animals such as cats and dogs.
Sanggu Kim, Preeti Kumari Chaudhary, Soochong Kim   +2 more
doaj   +1 more source

Platelet Biochemistry and Morphology after Cryopreservation [PDF]

, 2020
Platelet cryopreservation has been investigated for several decades as an alternative to room temperature storage of platelet concentrates. The use of dimethylsulfoxide as a cryoprotectant has improved platelet storage and cryopreserved concentrates can ...
Compernolle, Veerle, Feys, Hendrik, Six, Katrijn   +2 more
core   +1 more source

An Insight into GPCR and G-Proteins as Cancer Drivers

Cells, 2021
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling receptors known to play a crucial role in various physiological functions, including tumor growth and metastasis.
Preeti Kumari Chaudhary, Soochong Kim
doaj   +1 more source

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile

Frontiers in Cardiovascular Medicine, 2022
BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li, Li Li, Mark Roest, Yaqiu Sang, Yaqiu Sang, Jasper A. Remijn, Rob Fijnheer, Karel Smit, Dana Huskens, Dana Huskens, Jun Wan, Jun Wan, Bas de Laat, Bas de Laat, Joke Konings, Joke Konings   +15 more
doaj   +1 more source

High Glucose, But Not Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells [PDF]

, 2015
Endothelial cells inhibit platelet aggregation by releasing thromboregulators, such as prostacyclin and nitric oxide. Male subject is a traditional risk factor for cardiovascular diseases.
Aswin, S. (Soedjono), Jenie, I. M. (Ikhlas), Mulyono, B. (Budi), Soejono, S. K. (Sri)   +3 more
core   +2 more sources