Results 1 to 10 of about 679,715 (340)
Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicity
eLife, 2022 Background: Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. Existence of functional Notch signaling in enucleate platelets remains elusive.
Susheel N Chaurasia +5 more
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Life, 2023 EVs are membranous subcellular structures originating from various cells, including platelets which consist of biomolecules that can modify the target cell’s pathophysiological functions including inflammation, cell communication, coagulation, and ...
Preeti Kumari Chaudhary +2 more
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Animals, 2023 Glucocorticoids have been commonly used in the treatment of inflammation and immune-mediated diseases in human beings and small animals such as cats and dogs.
Sanggu Kim +2 more
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An Insight into GPCR and G-Proteins as Cancer Drivers
Cells, 2021 G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling receptors known to play a crucial role in various physiological functions, including tumor growth and metastasis.
Preeti Kumari Chaudhary, Soochong Kim
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Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile
Frontiers in Cardiovascular Medicine, 2022 BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li +15 more
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Immersed boundary simulations of cell-cell interactions in whole blood [PDF]
, 2021 We present a new method for the geometric reconstruction of elastic surfaces simulated by the immersed boundary method with the goal of simulating the motion and interactions of cells in whole blood. Our method uses parameter-free radial basis functions for high-order meshless parametric reconstruction of point clouds and the elastic force computations
arxiv +1 more source
Rupture Forces among Human Blood Platelets at different Degrees of Activation [PDF]
, 2020 Little is known about mechanics underlying the interaction among platelets during activation and aggregation. Although the strength of a blood thrombus has likely major biological importance, no previous study has measured directly the adhesion forces of single platelet-platelet interaction at different activation states.
arxiv +1 more source
Scientific Reports, 2017 Integrin αIIbβ3 mediates platelet aggregation and thrombus formation. In a rare hereditary bleeding disorder, Glanzmann thrombasthenia (GT), αIIbβ3 expression / function are impaired.
Matthieu Goguet +4 more
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Haematologica, 2020 Platelet adhesion to the sub-endothelial matrix and damaged endothelium occurs through a multi-step process mediated in the initial phase by glycoprotein Ib binding to von Willebrand factor (vWF), which leads to the subsequent formation of a platelet ...
Simona Stivala +7 more
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F1000Research, 2018 European and UK legislation requires all animal procedures to be conducted with consideration to reduction, refinement and replacement. In this review, 3Rs developments are discussed in the field of platelet biology and thromboembolism. Platelet research
Kirk A. Taylor, Michael Emerson
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