Results 1 to 10 of about 252,965 (339)

The Platelet-Activating Factor Receptor’s Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine [PDF]

open access: yesCells, 2021
The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development.
Eileen Deuster   +14 more
doaj   +2 more sources

Impact of targeting the platelet-activating factor and its receptor in cancer treatment [PDF]

open access: yesMilitary Medical Research
The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological and pathophysiological conditions, including cancer growth and metastasis.
Kimya Qaderi   +3 more
doaj   +2 more sources

Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer [PDF]

open access: yesCancer Cell International, 2021
Background Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like ...
YingYing He   +3 more
doaj   +2 more sources

PAF Physiology in Target Organ Systems—A Deep Dive to Understand the PAF Mystery in Pathogenesis of Disease

open access: yesHearts, 2021
The purpose of this literature review is to gain an overview of the role of platelet-activating factor (PAF) within each of the body systems and how it contributes to normal and pathophysiological states.
Nilank Shah, Karan Kumar, Nikeith Shah
doaj   +1 more source

UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment

open access: yesFrontiers in Immunology, 2022
Ultraviolet B radiation (UVB) has profound effects on human skin that results in a broad spectrum of immunological local and systemic responses and is the major cause of skin carcinogenesis.
Timothy C. Frommeyer   +10 more
doaj   +1 more source

The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging

open access: yesCardiogenetics, 2022
Hypertension and atherosclerosis are debilitating diseases that affect millions each year. Long-term consequences include but are not limited to stroke, myocardial infarction, and kidney failure.
Nilank Shah   +7 more
doaj   +1 more source

Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding [PDF]

open access: yesChemical Review and Letters, 2021
Studies and scientific research indicate that the platelet-activating factor (PAF) is a major pro-inflammatory mediator in the initiation and development of cancer.
Mohammed BOUACHRINE   +6 more
doaj   +1 more source

Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study

open access: yesClinical and Translational Allergy, 2019
Background Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of PAF by PAF acetylhydrolase (PAF-AH)
Bastsetseg Ulambayar   +5 more
doaj   +1 more source

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

open access: yesClinical and Applied Thrombosis/Hemostasis, 2021
The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the
Mark Klein MD   +2 more
doaj   +1 more source

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