Results 1 to 10 of about 107,670 (116)

Platelet activating factor in allergies

International Journal of Immunopathology and Pharmacology, 2015
The platelet-activating factor (PAF) produced and released by mast cells, basophils, neutrophils, eosinophils, fibroblasts, platelets, endothelial cells, and even cardiac muscle cells plays an important role in inflammatory and thrombotic diseases. PAF has been shown to be an important mediator in anaphylaxis.
Zbigniew Bartuzi
exaly   +3 more sources

Opposing Effects of Platelet-Activating Factor and Lyso-Platelet-Activating Factor on Neutrophil and Platelet Activation

Molecular Pharmacology, 2009
Platelet-activating factor (PAF) is a potent, bioactive phospholipid that acts on multiple cells and tissues through its G protein-coupled receptor (GPCR). PAF is not stored but is rapidly generated via enzymatic acetylation of the precursor 1-O-hexadecyl-2-hydroxy-sn-glycero-3-phosphocholine (lysoPAF). The bioactivity of PAF is effectively and tightly
Emily J, Welch, Ram P, Naikawadi, Zhenyu, Li, Phoebe, Lin, Satoshi, Ishii, Takao, Shimizu, Chinnaswamy, Tiruppathi, Xiaoping, Du, Papasani V, Subbaiah, Richard D, Ye   +9 more
openaire   +3 more sources

Platelet activating factor revisited [PDF]

Thorax, 1997
8A2 and acetyltransferase on membrane alkylacyl phospholipids. PAF was found to possess many properties that made it well suited as a proinflammatory mediator of inflammation in many inflammatory diseases. 1 Interest in Degradation of PAF its potential role as a mediator of asthma was fuelled Being a potent bioactive mediator, it makes sense that PAF ...
openaire   +2 more sources

Platelet-Activating Factor and Pain

Biological and Pharmaceutical Bulletin, 2011
Platelet-activating factor (PAF) is a phospholipid mediator that regulates the functions of a variety of cells in the peripheral tissues and in the nervous system. Findings that injection of PAF exogenously at the skin or in the spinal cord induced pain hypersensitivity gave us much attention to its role in pain signaling. Studies using pharmacological
Tsuda, Makoto, Tozaki-Saitoh, Hidetoshi, Inoue, Kazuhide   +2 more
openaire   +3 more sources

Inhibition by cardiolipins of platelet‐activating factor‐induced rabbit platelet activation

Lipids, 1993
AbstractEvidence is presented that cardiolipin, a naturally occurring phospholipid, inhibits the aggregatory effect of platelet‐activating factor (paf) on rabbit plateletsin vitro. Bovine heart cardiolipin was shown to inhibit the aggregation of washed rabbit platelets induced by 1×10−10 M and 2×10−10 M paf with IC50 values (doses for half‐maximal ...
Tsoukatos, D., Demopoulos, C.A., Tselepis, A.D., Moschidis, M.C., Donos, A., Evangelou, A., Benveniste, J.   +6 more
openaire   +4 more sources

Platelet-activating Factor Acetylhydrolases [PDF]

Journal of Biological Chemistry, 1997
D M, Stafforini, T M, McIntyre, G A, Zimmerman, S M, Prescott   +3 more
openaire   +2 more sources

Upregulation of Platelet-Activating Factor Receptor Expression and Lyso-Platelet-Activating Factor Isoforms in Human Nasal Polyp Tissues. [PDF]

J Clin Med, 2023
Roca-Ferrer J, Pérez-González M, Alobid I, Tubita V, Fuentes M, Bantulà M, Muñoz-Cano R, Valero A, Izquierdo I, Mullol J.   +9 more
europepmc   +1 more source

The Mediterranean Diet and Cardiovascular Protection: Biochemical Mechanisms with Emphasis on Platelet-Activating Factor. [PDF]

Nutrients
Detopoulou P, Antonopoulou S, Douvogianni P, Demopoulos CA.   +3 more
europepmc   +1 more source

Platelet-Activating Factor Pathway in Women With Metabolic Dysfunction-Associated Steatotic Liver Disease and Obesity. [PDF]

Obesity (Silver Spring)
Duran-Bertran J, Clavero-Mestres H, Mahmoudian R, Muñiz-Piera S, Aguilar C, Riesco D, Camaron J, Martínez S, Vives M, París M, Sabench F, Auguet T.   +11 more
europepmc   +1 more source

Associations of phase angle with platelet-activating factor metabolism and related dietary factors in healthy volunteers. [PDF]

Front Nutr, 2023
Detopoulou P, Fragopoulou E, Nomikos T, Antonopoulou S.   +3 more
europepmc   +1 more source