Results 1 to 10 of about 204,459 (333)

Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer

Frontiers in Oncology, 2020
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase widely expressed in cervical tumors, being correlated with adverse clinical outcomes. EGFR may be activated by a diversity of mechanisms, including transactivation by G-protein coupled
Juliana L. Souza, Karina Martins-Cardoso, Isabella S. Guimarães, Andréia C. de Melo, Angela H. Lopes, Robson Q. Monteiro, Vitor H. Almeida   +6 more
doaj   +1 more source

Platelet-Activating Factor Induces Th17 Cell Differentiation

Mediators of Inflammation, 2011
Th17 cells have been implicated in a number of inflammatory and autoimmune diseases. The phospholipid mediator platelet-activating factor (PAF) is found in increased concentrations in inflammatory lesions and has been shown to induce IL-6 production.
Anne-Marie Drolet, Maryse Thivierge, Sylvie Turcotte, Dominique Hanna, Bruno Maynard, Jana Stankovà, Marek Rola-Pleszczynski   +6 more
doaj   +1 more source

Design, Synthesis and Anti-Platelet Aggregation Activity Study of Ginkgolide-1,2,3-triazole Derivatives

Molecules, 2019
Ginkgolides are the major active component of Ginkgo biloba for inhibition of platelet activating factor receptor. An azide-alkyne Huisgen cycloaddition reaction was used to introduce a triazole nucleus into the target ginkgolide molecules.
Jian Cui, Le’An Hu, Wei Shi, Guozhen Cui, Xumu Zhang, Qing-Wen Zhang   +5 more
doaj   +1 more source

Fenofibrate induces HDL-associated PAF-AH but attenuates enzyme activity associated with apoB-containing lipoproteins

Journal of Lipid Research, 2003
Human plasma platelet-activating factor acetylhydrolase (PAF-AH) is an enzyme associated mainly with the apolipoprotein B (apoB)-containing lipoproteins and primarily with LDL. A small proportion of enzymatic activity is also associated with HDL.
Vasilis Tsimihodimos, Anna Kakafika, Afroditi P. Tambaki, Eleni Bairaktari, M.John Chapman, Moses Elisaf, Alexandros D. Tselepis   +6 more
doaj   +1 more source

Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients

Taiwanese Journal of Obstetrics & Gynecology, 2016
Objective: The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable ...
Ayla Eser, Ilknur Inegol Gumus, Husamettin Erdamar, Ikbal Kaygusuz, Melahat Yildirim, Betul Usluogullari, Muzeyyen Duran Erdolu, Serap Aynur Simavli, Ramazan Yigitoglu, Nilgun Ozturk Turhan   +9 more
doaj   +1 more source

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase

Frontiers in Immunology, 2017
Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock.
Yoshinari Yamamoto, Yoshinari Yamamoto, Ryu Sugimura, Takafumi Watanabe, Suguru Shigemori, Suguru Shigemori, Takuma Okajima, Shireen Nigar, Shireen Nigar, Fu Namai, Takashi Sato, Tasuku Ogita, Takeshi Shimosato, Takeshi Shimosato   +13 more
doaj   +1 more source

PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway[S]

Journal of Lipid Research, 2013
Platelet-activating factor (PAF), 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, is a potent phospholipid mediator and has been reported to be localized in atherosclerotic plaque.
Yun H. Kim, Seung J. Lee, Kyo W. Seo, Jin U. Bae, So Y. Park, Eun K. Kim, Sun S. Bae, Jae H. Kim, Chi D. Kim   +8 more
doaj   +1 more source

Perbedaan Kadar Platelet Activating Factor Plasma antara Penderita Demam Berdarah Dengue dan Demam Dengue

Majalah Kedokteran Bandung, 2013
Dengue virus infection can manifest as dengue fever and, more severely, as dengue hemorrhagic fever. Their pathogenesis until now is not fully understood.
Djatnika Setiabudi, Budi Setiabudiawan, Ida Parwati, Herry Garna   +3 more
doaj   +1 more source

The PON1 M55L gene polymorphism is associated with reduced HDL-associated PAF-AH activity

Journal of Lipid Research, 2003
The platelet-activating factor acetylhydrolase activity associated with high density lipoprotein (HDL-PAF-AH) may substantially contribute to the antioxidant, anti-inflammatory, and overall antiatherogenic effects of HDL.
Anna I. Kakafika, Stavroula Xenofontos, Vasilis Tsimihodimos, Afroditi P. Tambaki, Evangelia S. Lourida, Rigas Kalaitzidis, Marios A. Cariolou, Moses Elisaf, Alexandros D. Tselepis   +8 more
doaj   +1 more source

Prolonged Exposure to Platelet Activating Factor Transforms Breast Epithelial Cells

Frontiers in Genetics, 2021
Lipid species are known to have various biological functions owing to their structural differences, and each of them possesses a specific role to play depending upon their location and distribution in the cell. Some of these lipids interact with proteins
Vaishali Chakravarty, Libi Anandi, K. A. Ashiq, K. Abhijith, Rintu Umesh, Mayurika Lahiri   +5 more
doaj   +1 more source