Results 41 to 50 of about 24,574 (253)

Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease

Diabetes, Metabolic Syndrome and Obesity, 2022
Hang Yin, Anhua Shi, Junzi Wu Key Laboratory of Microcosmic Syndrome Differentiation, Yunnan University of Chinese Medicine, Kunming, People’s Republic of ChinaCorrespondence: Junzi Wu; Anhua Shi, Key Laboratory of Microcosmic Syndrome Differentiation ...
Yin H, Shi A, Wu J
doaj  

Apafant, a Potent Platelet-Activating Factor Antagonist, Blocks Eosinophil Activation and Is Effective in the Chronic Phase of Experimental Allergic Conjunctivitis in Guinea Pigs

Journal of Pharmacological Sciences, 2004
Platelet-activating factor (PAF) plays important roles in allergic reactions. In particular, there are many concerns about PAF, eosinophils, and the chronicity of allergic diseases.
Masatomo Kato, Kenji Imoto, Hideki Miyake, Tomoko Oda, Suguru Miyaji, Masatsugu Nakamura   +5 more
doaj   +1 more source

Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells [PDF]

, 2015
Melanoma cells often express platelet‑activating factor receptor (PAF‑R), which has been demonstrated to increase metastatic behavior. However, the effect of PAF‑R on the responsiveness of melanoma to naturally occurring cytotoxic agents remains to be ...
Sahu, Ravi Prakash
core   +1 more source

Characterization of Canine Platelet Activation Induced by Platelet Activating Factor (PAF)

Journal of Veterinary Medical Science, 2008
Characteristics of the signal transduction in Platelet activating factor (PAF)-activated platelets and effects of anti-platelet agents on this response were investigated in vitro for potential therapeutic applications in canine endotoxemia. Blockade of the PAF receptor by a specific blocker has the strongest inhibitive effect on the PAF-induced ...
Ryo, Tsuchiya, Yumiko, Tatsuki, Satoshi, Kitao, Mitsuru, Furuichi, Sakurako, Neo, Masaharu, Hisasue, Takatsugu, Yamada, Kosaku, Kobayashi   +7 more
openaire   +3 more sources

Platelet activating factor acetylhydrolase is associated with cardiac valvular calcification in dialysis patients

Türk Biyokimya Dergisi
The cardiovascular mortality risk is greatly increased in patients with chronic kidney disease (CKD), especially in dialysis patients, due to atherosclerosis.
Bolat Serkan, Fidancı Vildan, Elçik Deniz, Kavraz Tomar Özdem, Murat Sani Namık, Duranay Murat, Yücel Doğan   +6 more
doaj   +1 more source

Aqueous Zinc‐Based Batteries: Active Materials, Device Design, and Future Perspectives

Advanced Energy Materials, EarlyView.
This review conducts a comprehensive analysis of aqueous zinc‐based batteries (AZBs) based on their intrinsic mechanisms, including redox reactions, ion intercalation reactions, alloying reactions, electrochemical double‐layer reactions, and mixed mechanisms, systematically discussing recent advancements in each type of AZBs.
Yan Ran, Fang Dong, Shuhui Sun, Yong Lei
wiley   +1 more source

Platelet-activating factor acetylhydrolase and haemophagocytosis in the sepsis syndrome

Mediators of Inflammation, 2000
Sepsis syndrome (SS) is associated with depressed PAF acetylhydrolase, the enzyme responsible for the degradation of platelet activating factor.
Franck Trimoreau, Bruno François, Arnaud Desachy, Arnaud Besse, Philippe Vignon, Yves Denizot   +5 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core   +1 more source

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source