Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of cd36 and platelet-activating factor receptor [PDF]
, 2013 Phagocytosis of apoptotic cells (efferocytosis) induces macrophage differentiation towards a regulatory phenotype (IL-10high/IL-12p40low). CD36 is involved in the recognition of apoptotic cells (AC), and we have shown that the platelet-activating factor ...
Ferracini, M. +3 more
core +2 more sources
Platelet-Activating Factor-Receptor and Tumor Immunity [PDF]
, 2014 First described in 1972 by Benveniste and colleagues, platelet-activating factor (PAF) remains one of the potent phospholipid known to date. The role of PAF produced enzymatically in mediating diverse biological and pathophysiological processes including
Konger, Raymond L. +2 more
core
Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food
Allergy, EarlyView.ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy +7 more
wiley +1 more source
Journal of Lipid Research, 2001 Unmitigated oxidative stress is deleterious, as epitomized by CCl4 intoxication. In this well-characterized model of free radical-initiated damage, liver metabolism of CCl4 to CCl3.
Gopal K. Marathe +8 more
doaj +1 more source
LAU-0901, a novel platelet-activating factor receptor antagonist, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat [PDF]
, 2009 LAU-0901, a novel platelet-activating factor (PAF) receptor antagonist, is highly neuroprotective in a rodent model of cerebral ischemia. This study was conducted to establish whether the neuroprotection induced by LAU-0901 persists with chronic survival.
Atkins, Kristal +5 more
core +2 more sources
Allergy, EarlyView.ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
T. Zuberbier +221 more
wiley +1 more source
Journal of Lipid Research, 1998 The metabolism of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) was investigated in FRTL5 cells, a normal rat thyroid cell line.
Eleni Botitsi +2 more
doaj +1 more source
Platelet-activating factor and hyperacute rejection: The effect of a platelet-activating factor antagonist, sri 63-441, on rejection of xenografts and allografts in sensitized hosts [PDF]
, 1990 The pathogenesis of hyperacute transplantation reactions includes the activation of a cascade of nonspecific inflammatory reactions that precipitates the destruction of the target organ.
Chapman, FA +5 more
core +1 more source
The Cardiovascular Effect of the Platelet Activator Factor
Journal of Biological Research, 2003 Platelet activating factor (PAF) is one of the most potent mediators found in mammals. PAF is a phospholipid with diverse and potent physiological effects; it is a mediator of cell – to cell communication,which may function either as a intercellular and
C. Penna
doaj +1 more source
Mice with genetic deletion of group VIA phospholipase A2β exhibit impaired macrophage function and increased parasite load in Trypanosoma cruzi-induced myocarditis [PDF]
, 2016 Trypanosoma cruzi infection, which is the etiological agent of Chagas disease, is associated with intense inflammation during the acute and chronic phases.
Blase, Jennifer R +5 more
core +2 more sources