Results 61 to 70 of about 74,663 (286)

Platelet-Activating Factor-Receptor and Tumor Immunity [PDF]

, 2014
First described in 1972 by Benveniste and colleagues, platelet-activating factor (PAF) remains one of the potent phospholipid known to date. The role of PAF produced enzymatically in mediating diverse biological and pathophysiological processes including
Konger, Raymond L., Sahu, Ravi P., Travers, Jeffrey B.   +2 more
core  

LAU-0901, a novel platelet-activating factor receptor antagonist, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat [PDF]

, 2009
LAU-0901, a novel platelet-activating factor (PAF) receptor antagonist, is highly neuroprotective in a rodent model of cerebral ischemia. This study was conducted to establish whether the neuroprotection induced by LAU-0901 persists with chronic survival.
Atkins, Kristal, Bazan, Nicolas G., Belayev, Ludmila, Cherqui, Alice, Khoutorova, Larissa, Álvarez-Builla Gómez, Julio   +5 more
core   +2 more sources

Platelet activating factor (PAF) induced release of platelet factor 4 (PF4) in vitro and during IgE anaphylaxis in the rabbit.

Journal of Immunology, 1979
Basophil-derived platelet activating factor (PAF) was shown to induce the release of platelet factor 4 (PF4), a specific platelet protein, from isolated, washed rabbit platelets.
L. McManus, C. Morley, S. P. Levine, R. N. Pinckard   +3 more
semanticscholar   +1 more source

Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver

Journal of Lipid Research, 2001
Unmitigated oxidative stress is deleterious, as epitomized by CCl4 intoxication. In this well-characterized model of free radical-initiated damage, liver metabolism of CCl4 to CCl3.
Gopal K. Marathe, Kathleen A. Harrison, L. Jackson Roberts, II, Jason D. Morrow, Robert C. Murphy, Larry W. Tjoelker, Stephen M. Prescott, Guy A. Zimmerman, Thomas M. McIntyre   +8 more
doaj   +1 more source

Cancer therapy-induced PAFR ligand expression: any role for caspase activity? [PDF]

, 2017
No abstract ...
G Ichim, Gabriel Ichim, K Lauber, Q Huang, RP Sahu, RP Sahu, Stephen W. G. Tait, X Zhao   +7 more
core   +1 more source

Possible involvement of keratinocyte‐derived microvesicle particles in human photosensitivity disorders

Photochemistry and Photobiology, EarlyView.
In this model, ROS generated by UVB result in PAFR agonists acting upon the PAFR resulting in MVP generation release via the enzyme aSMase. In photosensitivity, there are increased ROS, resulting in augmented PAF agonists and increased MVP release. This process can be blocked by aSMase inhibitors.
Risha Annamraju, Madison S. Owens, Anita Thyagarajan, Danielle A. Corbin, Catherine M. T. Sherwin, Jade Bryant, Garrett W. Fisher, Winston R. Owens, Alycia Ketter, Aadil Umerani, Craig A. Rohan, Michael G. Kemp, Robyn K. Crow, Jeffrey B. Travers   +13 more
wiley   +1 more source

The Cardiovascular Effect of the Platelet Activator Factor

Journal of Biological Research, 2003
Platelet activating factor (PAF) is one of the most potent mediators found in mammals. PAF is a phospholipid with diverse and potent physiological effects; it is a mediator of cell – to cell communication,which may function either as a intercellular and
C. Penna
doaj   +1 more source

Atrial fibrosis in atrial fibrillation: Mechanisms, mapping techniques and clinical applications

The Journal of Physiology, EarlyView.
Abstract figure legend Summary of key aspects of atrial fibrosis in atrial fibrillation, highlighting atrial fibrosis as a hallmark of atrial fibrillation (AF). (1) Different types of fibrosis (blue), illustrating reparative and reactive fibrosis; (2) fibrosis detection techniques (green), illustrating late gadolinium enhancement cardiac magnetic ...
Caterina Vidal Horrach, Laura Bevis, Cynthia Nwanna, Alexander M Zolotarev, Mahmoud Ehnesh, Semhar Biniam Misghina, Sayed Al‐Aidarous, Shohreh Honarbakhsh, Caroline H. Roney   +8 more
wiley   +1 more source

Platelet Activating Factor Synthesis and Metabolism in Intestinal Ischaemia-Reperfusion Injury

Mediators of Inflammation, 1994
The object of this study was to characterize the synthesis and metabolism of platelet activating factor (PAF) by intestinal mucosa subjected to ischaemia–reperfusion injury.
M. J. Mangino, M. Murphy, A. Bohrer, J. Turk   +3 more
doaj   +1 more source

Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation

Molecules, 2010
Phylligenine, together with quebrachitol, stigmasterol and two aporphine alkaloids—oxoputerine and liriodenine—were isolated from the twigs of Mitrephora vulpina C.E.C. Fisch.
Khozirah Shaari, Bushra Abdulkarim Moharam, Juriyati Jalil, Ibrahim Jantan   +3 more
doaj   +1 more source