Results 131 to 140 of about 1,067,744 (311)

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Dysregulation of platelet serotonin, 14–3–3, and GPIX in sudden infant death syndrome

Scientific Reports
Sudden infant death syndrome (SIDS) is the leading cause of post-neonatal infant mortality, but the underlying cause(s) are unclear. A subset of SIDS infants has abnormalities in the neurotransmitter, serotonin (5-hydroxytryptamine [5-HT]) and the ...
Andrew L. Frelinger, Robin L. Haynes, Richard D. Goldstein, Michelle A. Berny-Lang, Anja J. Gerrits, Molly Riehs, Elisabeth A. Haas, Brankica Paunovic, Othon J. Mena, Steven C. Campman, Ginger L. Milne, Lynn A. Sleeper, Hannah C. Kinney, Alan D. Michelson   +13 more
doaj   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

The proteome of circulating extracellular vesicles and their functional effect on platelets vary with the isolation method

Scientific Reports
Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication and serve as a source of biomarkers in several pathologies. In this study, we aimed to characterize plasma-derived EVs isolated by ultracentrifugation (UC) or size exclusion ...
Eva M. Fernández-Sáez, Susana B. Bravo, Carmen Pena, Ángel García   +3 more
doaj   +1 more source

Using Platelet-Rich Plasma to Reverse the Effects of Tendinopathy and Prevent Tendon Re-rupture after Surgery in Athletes: The Search for a Standardized Protocol [PDF]

, 2016
30-50% of all lesions amateur and professional sports players will experience during activity are related to the tendon. Moreover, the incidence of tendinopathy, a precursor to tendon rupture, is much higher in both of these groups due to excessive ...
Patel, Shiv
core   +1 more source

Patient‐Derived 3D Bioprinted Cardiac Organoid Constructs Reveal Key Pathological Features of Duchenne Muscular Dystrophy

Advanced Healthcare Materials, EarlyView.
Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini, Margalida Campaner Socias, Andreas Dimopoulos, Lorenza Rinvenuto, Enrico Pozzo, Diana Stalkopf, Angelo Serafini, Sara Morri, Ashley Wang, Rita La Rovere, Yoke Chin Chai, Sveva Bollini, Geert Bultynck, H. Llewelyn Roderick, Ioannis Papantoniou, Maurilio Sampaolesi   +15 more
wiley   +1 more source

Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics

Scientific Reports
Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin.
Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +9 more
doaj   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Improving prediction of fetal/neonatal intracranial hemorrhage in HPA‐1a alloimmunized pregnancies to guide antenatal management: An observational cohort study

Acta Obstetricia et Gynecologica Scandinavica
Introduction Maternal alloimmunization against human platelet antigen‐1a (HPA‐1a) may lead to severe intracranial hemorrhage (ICH) in the fetus or newborn as a life‐threatening complication of fetal neonatal alloimmune thrombocytopenia (FNAIT).
Siw Leiknes Ernstsen, Maria Therese Ahlen, Eirin Listau Bertelsen, Jens Kjeldsen‐Kragh, Anne Husebekk, Heidi Tiller   +5 more
doaj   +1 more source

Hybrid Nanofibers for Multimodal Accelerated Wound Healing

Advanced Healthcare Materials, EarlyView.
Fabrication of wound healing scaffolds based on biocompatible nanofibers. Nanofibers offering high surface area, flexibility, and biocompatibility significantly improved the healing outcome in vivo. Histological, immunological, and anti‐inflammatory markers are noticeably better in treated wounds.
Viraj P. Nirwan, Bence Bajusz, Norbert Fabók, Marina Rudan Dimlic, Jelena Budimir, Tshepang Mqatywa, Miklós Gyöngy, Márton Ferencz, Dorottya Kocsis, Olexandr Bondarenko, Mariia Rolduhina, Milena Lengyel, Istvan Antal, Rebecca Hengsbach, Franciska Erdő, Amir Fahmi   +15 more
wiley   +1 more source