Platelet activating factor revisited [PDF]
Thorax, 1997 8A2 and acetyltransferase on membrane alkylacyl phospholipids. PAF was found to possess many properties that made it well suited as a proinflammatory mediator of inflammation in many inflammatory diseases. 1 Interest in Degradation of PAF its potential role as a mediator of asthma was fuelled Being a potent bioactive mediator, it makes sense that PAF ...
Kian Fan Chung
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Understanding the Activation of Platelets in Diabetes and Its Modulation by Allyl Methyl Sulfide, an Active Metabolite of Garlic [PDF]
Journal of Diabetes Research, 2021 Background. Diabetes mellitus (DM) is a chronic metabolic disorder associated with higher risk of having cardiovascular disease. Platelets play a promising role in the pathogenesis of cardiovascular complications in diabetes.
Navya Malladi +6 more
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Platelets, 2022 Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson +7 more
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Baseline Platelet Activation and Reactivity in Patients with Critical Limb Ischemia. [PDF]
PLoS ONE, 2015 Patients with critical limb ischemia (CLI) have a high risk to develop cardiovascular events (CVE). We hypothesized that in CLI patients platelets would display increased baseline activation and reactivity.We investigated baseline platelet activation and
Peter Paul Wisman +5 more
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C1-inhibitor influence on platelet activation by thrombin receptors agonists
Clinical and Applied Thrombosis/Hemostasis, 2022 Introduction Protease activated receptors 1 (PAR1) and 4 (PAR4) agonists are used to study platelet activation. Data on platelet activation are extrapolated across experimental settings.
Ivan D. Tarandovskiy PhD +2 more
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The Dynamics of Platelet Activation during the Progression of Streptococcal Sepsis. [PDF]
PLoS ONE, 2016 Platelets contribute to inflammation however, the role of platelet activation during the pathophysiological response to invasive bacterial infection and sepsis is not clear.
Sinead M Hurley +3 more
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Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse. [PDF]
PLoS ONE, 2015 Recent work has indicated that platelets, which are anucleate blood cells, significantly contribute to inflammatory disorders. Importantly, platelets also likely contribute to various inflammatory secondary disorders that are increasingly associated with
Michelle Kiebala +5 more
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Zinc: an endogenous and exogenous regulator of platelet function during hemostasis and thrombosis
Platelets, 2021 Zinc (Zn2+) is an essential micronutrient and the second most abundant trace metal in the human body. The important role that Zn2+ plays in hemostasis is exemplified by platelet-related bleeding phenotypes coinciding with dietary Zn2+ deficiency.
Niaz Shahed Ahmed +2 more
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Application of an optimized flow cytometry-based quantification of Platelet Activation (PACT): Monitoring platelet activation in platelet concentrates. [PDF]
PLoS ONE, 2017 BACKGROUND:Previous studies have shown that flow cytometry is a reliable test to quantify platelet function in stored platelet concentrates (PC). It is thought that flow cytometry is laborious and hence expensive.
Cécile H Kicken +4 more
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Frontiers in Immunology, 2022 BackgroundChancre self-healing, a typical clinical phenomenon of primary syphilis, is essentially wound healing. The first response to a wound is constriction of the injured blood vessels and activation of platelets to form a fibrin clot.
Qiu-Yan Xu +9 more
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