Results 1 to 10 of about 4,119,343 (427)

The effects of signal transducer and activator of transcription three mutations on human platelets [PDF]

Platelets, 2018
Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested.
Floor E. Aleva, Frank L. van de Veerdonk, Yang Li, Rahajeng N. Tunjungputri, Sami Simons, Philip G. De Groot, Mihai M. Netea, Yvonne F. Heijdra, Quirijn de Mast, André J.A.M. van der Ven   +9 more
doaj   +4 more sources

Mechanisms of Hemolysis-Associated Platelet Activation [PDF]

Journal of Thrombosis and Haemostasis, 2013
Background Intravascular hemolysis occurs after blood transfusion, in hemolytic anemias, and in other conditions, and is associated with hypercoagulable states.
Christ, G., Gladwin, M. T., Hantgan, R. R., Helms, Christine C., Kato, G. J., Kim-Shapiro, D. B., Lee, J. S., Marvel, M., Stahle, M., Vest, R., Zhao, W.   +10 more
core   +3 more sources

Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αiIbβ3, and platelet factor 4 [PDF]

Blood, 2014
Bacterial adhesion to platelets is mediated via a range of strain-specific bacterial surface proteins that bind to a variety of platelet receptors. It is unclear how these interactions lead to platelet activation.
Arman, Mònica, Cox, Dermot, Greinacher, Andreas, Kerrigan, Steven W., Krauel, Krystin, Tilley, Dorothea O., Watson, Steve P., Weber, Claudia   +7 more
core   +2 more sources

Endogenous SIRT6 in platelets negatively regulates platelet activation and thrombosis [PDF]

Frontiers in Pharmacology, 2023
Thromboembolism resulting from platelet dysfunction constitutes a significant contributor to the development of cardiovascular disease. Sirtuin 6 (SIRT6), an essential NAD+-dependent enzyme, has been linked to arterial thrombosis when absent in ...
Yanli Liu, Tao Wang, Qilong Zhou, Guang Xin, Hai Niu, Fan Li, Yilan Wang, Shiyi Li, Yuman Dong, Kun Zhang, Lijuan Feng, Wei Fu, Boli Zhang, Wen Huang   +13 more
doaj   +2 more sources

Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation [PDF]

Journal of Biomedical Science, 2010
Background 3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been widely used to reduce cardiovascular risk. These statins (i.e., simvastatin) may exert other effects besides from their cholesterol-lowering actions ...
Hou Ssu-Yu, Jayakumar Thanasekaran, Chou Duen-Suey, Chen Wei-Fan, Lee Ye-Ming, Lee Jie-Jen, Hsiao George, Sheu Joen-Rong   +7 more
doaj   +4 more sources

Eugenol: A Potential Modulator of Human Platelet Activation and Mouse Mesenteric Vascular Thrombosis via an Innovative cPLA2-NF-κB Signaling Axis [PDF]

Biomedicines
Background: Platelets, a type of anucleated cell, play a crucial role in cardiovascular diseases (CVDs). Therefore, targeting platelet activation is essential for mitigating CVDs.
Yi Chang, Chih-Wei Hsia, Kuan-Rau Chiou, Ting-Lin Yen, Thanasekaran Jayakumar, Joen-Rong Sheu, Wei-Chieh Huang   +6 more
doaj   +2 more sources

Biomarkers of Complement and Platelet Activation are not correlated with the One or Twenty-Four Hours Corrected Count Increments in Prophylactically Platelet Transfused Hematological Patients: a Prospective Cohort Study

Platelets, 2022
Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson, Marcus Ljungkvist, Myriam Martin, Anna M. Blom, Jenny Klintman, Ulf Schött, Eva Zetterberg, Thomas Kander   +7 more
doaj   +1 more source

Baseline Platelet Activation and Reactivity in Patients with Critical Limb Ischemia. [PDF]

PLoS ONE, 2015
Patients with critical limb ischemia (CLI) have a high risk to develop cardiovascular events (CVE). We hypothesized that in CLI patients platelets would display increased baseline activation and reactivity.We investigated baseline platelet activation and
Peter Paul Wisman, Martin Teraa, Gert Jan de Borst, Marianne C Verhaar, Mark Roest, Frans L Moll   +5 more
doaj   +1 more source

C1-inhibitor influence on platelet activation by thrombin receptors agonists

Clinical and Applied Thrombosis/Hemostasis, 2022
Introduction Protease activated receptors 1 (PAR1) and 4 (PAR4) agonists are used to study platelet activation. Data on platelet activation are extrapolated across experimental settings.
Ivan D. Tarandovskiy PhD, Paul W. Buehler PhD, Elena Karnaukhova PhD   +2 more
doaj   +1 more source

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

Blood, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel coronavirus has rapidly achieved pandemic proportions causing remarkably ...
E. D. Hottz, Isaclaudia G. Azevedo-Quintanilha, Lohanna Palhinha, Lívia Teixeira, Ester A. Barreto, Camila R. R. Pão, C. Righy, Sergio A L Franco, T. M. Souza, P. Kurtz, F. Bozza, P. Bozza   +11 more
semanticscholar   +1 more source