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Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985 Platelets are discoidal cytoplasmic particles that respond to a variety of stimuli by developing filopodia and rounding up (shape change), developing the ability to bind fibrinogen from the medium, and, with strong stimuli such as thrombin and PAF-acether, secreting the contents of several types of granules.
M B, Zucker, V T, Nachmias
openaire +3 more sources
The effects of signal transducer and activator of transcription three mutations on human platelets [PDF]
Platelets, 2018 Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested.
Floor E. Aleva +9 more
doaj +4 more sources
Endogenous SIRT6 in platelets negatively regulates platelet activation and thrombosis [PDF]
Frontiers in Pharmacology, 2023 Thromboembolism resulting from platelet dysfunction constitutes a significant contributor to the development of cardiovascular disease. Sirtuin 6 (SIRT6), an essential NAD+-dependent enzyme, has been linked to arterial thrombosis when absent in ...
Yanli Liu +13 more
doaj +2 more sources
Mechanisms of Hemolysis-Associated Platelet Activation [PDF]
Journal of Thrombosis and Haemostasis, 2013 Background Intravascular hemolysis occurs after blood transfusion, in hemolytic anemias, and in other conditions, and is associated with hypercoagulable states.
Christ, G. +10 more
core +3 more sources
Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αiIbβ3, and platelet factor 4 [PDF]
Blood, 2014 Bacterial adhesion to platelets is mediated via a range of strain-specific bacterial surface proteins that bind to a variety of platelet receptors. It is unclear how these interactions lead to platelet activation.
Arman, Mònica +7 more
core +2 more sources
Journal of Thrombosis and Haemostasis, 2013 Worldwide, dengue is the most prevalent human arbovirus disease. Dengue infection may cause a range of clinical manifestations from self‐limiting febrile illness through to a life‐threatening syndrome accompanied by both bleeding and shock ...
Fernando A Bozza
exaly +2 more sources
Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation [PDF]
Journal of Biomedical Science, 2010 Background 3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been widely used to reduce cardiovascular risk. These statins (i.e., simvastatin) may exert other effects besides from their cholesterol-lowering actions ...
Hou Ssu-Yu +7 more
doaj +4 more sources
Eugenol: A Potential Modulator of Human Platelet Activation and Mouse Mesenteric Vascular Thrombosis via an Innovative cPLA2-NF-κB Signaling Axis [PDF]
BiomedicinesBackground: Platelets, a type of anucleated cell, play a crucial role in cardiovascular diseases (CVDs). Therefore, targeting platelet activation is essential for mitigating CVDs.
Yi Chang +6 more
doaj +2 more sources
Platelets, 2022 Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson +7 more
doaj +1 more source
Baseline Platelet Activation and Reactivity in Patients with Critical Limb Ischemia. [PDF]
PLoS ONE, 2015 Patients with critical limb ischemia (CLI) have a high risk to develop cardiovascular events (CVE). We hypothesized that in CLI patients platelets would display increased baseline activation and reactivity.We investigated baseline platelet activation and
Peter Paul Wisman +5 more
doaj +1 more source