Results 1 to 10 of about 195,699 (241)

The Effect of Paraprotein on Platelet Aggregation [PDF]

Journal of Clinical Laboratory Analysis, 2014
Background Some patients with paraproteinemia have platelet aggregation disorders and the aim of this study was to examine disturbance of platelet aggregation in healthy blood donors by isolated paraprotein in vitro.
Amzel, Apitz, Born, Decourt, Di Minno, Dighiero, Edelman, Edelman, Freedman, Garver, Jefferis, Jefferis, Kawai, Kerr, Lefranc, Libman, Mejbaum-Katzenellenbogen, Porter, Recht, Riva, Robert, Sagan, Shinagawa, Spicka, Spicka, Stanworth, Tricot, Virella, Werner   +28 more
core   +6 more sources

Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway [PDF]

, 2013
Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases.
Elgheznawy, Amro, Fleming, Ingrid, Hadas, Karin, Mann, Alexander, Randriamboavonjy, Voahanginirina   +4 more
core   +9 more sources

An investigation of the antiplatelet effects of succinobucol (AGI-1067) [PDF]

, 2016
Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. Given the importance of oxidant stress in modulating platelet–platelet and platelet–vessel wall interactions, the aim of this study was to establish if antioxidant ...
Gnanadesika, Sukanya, Houston, Stephanie A., Kennedy, Simon, Ugusman, Azizah   +3 more
core   +1 more source

High Glucose, But Not Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells [PDF]

, 2015
Endothelial cells inhibit platelet aggregation by releasing thromboregulators, such as prostacyclin and nitric oxide. Male subject is a traditional risk factor for cardiovascular diseases.
Aswin, S. (Soedjono), Jenie, I. M. (Ikhlas), Mulyono, B. (Budi), Soejono, S. K. (Sri)   +3 more
core   +2 more sources

Aggregation of platelets by collagen [PDF]

Journal of Clinical Investigation, 1968
In studying some of the properties of collagen responsible for the ability to aggregate platelets it was found that thermal treatment at pH 2.5 of acid-soluble human collagen resulted in a sharp reduction in relative viscosity and platelet aggregating activity at about 35 degrees C.
G. D. Wilner, Hymie L. Nossel, E. C. LeRoy   +2 more
openaire   +3 more sources

Platelet inhibitory effects of the Phase 3 anticancer and normal tissue cytoprotective agent, RRx-001. [PDF]

, 2018
The platelet inhibitory effects of the Phase 3 anticancer agent and nitric oxide (NO) donor, RRx-001, (1-bromoacetyl-3,3-dinitroazetidine) were examined ex vivo and compared with the diazeniumdiolate NO donor, diethylenetriamine NONOate (DETA-NONOate ...
Bryan Oronsky, Neil Oronsky, Pedro Cabrales, Santoro SA   +3 more
core   +1 more source

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation. [PDF]

, 2015
Regular consumption of chocolate and cocoa products has been linked to reduced cardiovascular mortality. This study compared the effects of high flavanol dark chocolate (HFDC; 1064mg flavanols/day for 6 weeks) and low flavanol dark chocolate (LFDC; 88mg ...
Akita, Armstrong, Atholl Johnston, Avolio, Balzer, Buijsse, Buijsse, Butcher, Curtis, Curtis, Custodis, David J. Collier, Duprez, Engler, Flammer, Flammer, Fredholm, Grassi, Grassi, Gresele, Gu, Gurvinder Rull, Heiss, Hermann, Holland, Holt, Innes, Janszky, Julian Shiel, Kokubo, Kris-Etherton, Kris-Etherton, Lakatta, Langer, Larsson, Larsson, Laurent, Lopez-Garcia, Manisty, Martina H. Lundberg, Murphy, Pereira, Rambaran, Rein, Ried, Roger Corder, Schroeter, Sever, Sharman, Smolenski, Taubert, Thorin, Timothy D. Warner, Varughese, Williams, Yu, Zetty N. Mohd-Zain   +56 more
core   +1 more source

Digoxin and platelet activation in patients with atrial fibrillation: In vivo and in vitro study [PDF]

, 2018
Background-Digoxin use was shown to be associated with an increased risk of cardiovascular events in atrial fibrillation (AF). We hypothesized that digoxin may affect cardiovascular risk by increasing platelet activation.
Bartimoccia, Simona, Cammisotto, Vittoria, Carnevale, Roberto, Nocella, Cristina, Novo, Marta, Pastori, Daniele, Piconese, Silvia, Pignatelli, Pasquale, Santulli, Maria, Vasaturo, Fortunata, Violi, Francesco   +10 more
core   +1 more source

Correlation Between P-Selectin Level and Platelet Aggregation in Cerebral Venous Sinus Thrombosis Patients [PDF]

, 2023
One of the causes of cerebral venous sinus thrombosis (CVST) is platelet hyperactivity. Adhesion and secretion are the beginning of platelet activation, which is indicated by a change in the Platelet-selectin (P-selectin) level.
Amalia, Lisda, Indrati, Agnes Rengga, Lismayanti, Leni, Nurmin, Rahmawati, Rostini, Tiene   +4 more
core   +1 more source