clotFoam: An Open-Source Framework to Simulate Blood Clot Formation Under Arterial Flow [PDF]
SoftwareX (2023) 101483, 2023 Blood clotting involves the coupled processes of platelet aggregation and coagulation. Simulating clotting under flow in complex geometries is challenging due to multiple temporal and spatial scales and high computational cost. clotFoam is an open-source software developed in OpenFOAM that employs a continuum model of platelet advection, diffusion, and
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Mechanobiology of shear-induced platelet aggregation leading to occlusive arterial thrombosis: a multiscale in silico analysis [PDF]
, 2021 Occlusive thrombosis in arteries causes heart attacks and strokes. The rapid growth of thrombus at elevated shear rates (~10,000 1/s) relies on shear-induced platelet aggregation (SIPA) thought to come about from the entanglement of von Willebrand factor (VWF) molecules.
arxiv +1 more source
AI-aided multiscale modeling of physiologically-significant blood clots [PDF]
, 2022 We have developed an AI-aided multiple time stepping (AI-MTS) algorithm and multiscale modeling framework (AI-MSM) and implemented them on the Summit-like supercomputer, AIMOS. AI-MSM is the first of its kind to integrate multi-physics, including intra-platelet, inter-platelet, and fluid-platelet interactions, into one system. It has simulated a record-
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Rupture Forces among Human Blood Platelets at different Degrees of Activation [PDF]
, 2020 Little is known about mechanics underlying the interaction among platelets during activation and aggregation. Although the strength of a blood thrombus has likely major biological importance, no previous study has measured directly the adhesion forces of single platelet-platelet interaction at different activation states.
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A continuum model for the unfolding of von Willebrand Factor [PDF]
, 2021 von Willebrand Factor is a mechano-sensitive protein circulating in blood that mediates platelet adhesion to subendothelial collagen and platelet aggregation at high shear rates. Its hemostatic function and thrombogenic effect, as well as susceptibility to enzymatic cleavage, are regulated by a conformational change from a collapsed globular state to a
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Aging of the Nonlinear Optical Susceptibility of colloidal solutions [PDF]
Phys. Rev. B 75, 224203 (2007), 2006 Using Z-scan and dynamic light scattering measurements we investigate the nonlinear optics response of a colloidal solution undergoing dynamics slowing down with age. We study the high optical nonlinearity of an organic dye (Rhodamine B) dispersed in a water-clay (Laponite) solution, at different clay concentrations (2.0 wt% - 2.6 wt%), experiencing ...
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Three-dimensional Multiscale Model of Deformable Platelets Adhesion to Vessel Wall in Blood Flow [PDF]
, 2013 When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation.
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Use of ultrasound attenuation spectroscopy to determine the size distribution of clay tactoids in aqueous suspensions [PDF]
Langmuir, 29, 12663 (2013), 2014 The dispersion processes of aqueous samples of clay are studied using ultrasound attenuation spectroscopy. The attenuation spectra that are acquired in the frequency range $10-100$ MHz are used to determine the particle size distributions (PSDs) for different concentrations and ages of the clay suspensions.
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Aggregation of Red Blood Cells: From Rouleaux to Clot Formation [PDF]
Comptes Rendues en Physique 14, 459 (2013), 2013 Red blood cells are known to form aggregates in the form of rouleaux. This aggregation process is believed to be reversible, but there is still no full understanding on the binding mechanism. There are at least two competing models, based either on bridging or on depletion.
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A Mathematical Model of Platelet Aggregation in an Extravascular Injury Under Flow [PDF]
arXiv, 2020 We present the first mathematical model of flow-mediated primary hemostasis in an extravascular injury, which can track the process from initial deposition to occlusion. The model consists of a system of ordinary differential equations (ODE) that describe platelet aggregation (adhesion and cohesion), soluble-agonist-dependent platelet activation, and ...
arxiv