Results 1 to 10 of about 123,010 (259)

An investigation of the antiplatelet effects of succinobucol (AGI-1067) [PDF]

Platelets, 2017
Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. Given the importance of oxidant stress in modulating platelet–platelet and platelet–vessel wall interactions, the aim of this study was to establish if antioxidant ...
Stephanie A. Houston, Azizah Ugusman, Sukanya Gnanadesikan, Simon Kennedy   +3 more
doaj   +2 more sources

Macrostachyols A-D, oligostilbenes from Gnetum macrostachyum inhibited in vitro human platelet aggregation [PDF]

Journal of HerbMed Pharmacology, 2021
Introduction: Gnetum macrostachyum is a known Thai medicinal plant as a source of bioactive oligostilbenes, which possess platelet inhibitory activities.
Serm Surapinit, Nuttakorn Baisaeng
doaj   +1 more source

Ex vivo STUDY OF THE ACTION OF INTEGRIN RECEPTORS ANTAGONIST FROM ECHIS MULTISQUAMATIS SNAKE VENOM ON PLATELETS OF PREGNANT WOMEN WITH COMPICATIONS DURING GESTATION [PDF]

Biotechnologia Acta, 2023
Aim. In our work, we studied platelet aggregation in blood plasma of pregnant women and estimated the possibility of ex vivo normalization of aggregation rate using a polypeptide from the Echis multisquamatus snake venom.
O. M. PLATONOV, I. V. US
doaj   +1 more source

The Ratio of ADP- to TRAP-Induced Platelet Aggregation Quantifies P2Y12-Dependent Platelet Inhibition Independently of the Platelet Count. [PDF]

PLoS ONE, 2016
This study aimed to assess the association of clinical factors with P2Y12-dependent platelet inhibition as monitored by the ratio of ADP- to TRAP-induced platelet aggregation and conventional ADP-induced aggregation, respectively.Controversial findings ...
Christoph B Olivier, Melanie Meyer, Hans Bauer, Katharina Schnabel, Patrick Weik, Qian Zhou, Christoph Bode, Martin Moser, Philipp Diehl   +8 more
doaj   +1 more source

Correlation Between P-Selectin Level and Platelet Aggregation in Cerebral Venous Sinus Thrombosis Patients

Majalah Kedokteran Bandung, 2023
One of the causes of cerebral venous sinus thrombosis (CVST) is platelet hyperactivity. Adhesion and secretion are the beginning of platelet activation, which is indicated by a change in the Platelet-selectin (P-selectin) level.
Rahmawati Nurmin, Leni Lismayanti, Tiene Rostini, Agnes Rengga Indrati, Lisda Amalia   +4 more
doaj   +1 more source

Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice

Journal of Pharmacological Sciences, 2022
Quinonoid dihydropteridine reductase (QDPR) regenerates tetrahydrobiopterin (BH4), which is an essential cofactor for catecholamine and serotonin (5-hydroxytryptamine, 5-HT) biosynthesis.
Yui Suganuma, Chiho Sumi-Ichinose, Taiki Kano, Kazuhisa Ikemoto, Taei Matsui, Hiroshi Ichinose, Kazunao Kondo   +6 more
doaj   +1 more source

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

Optimized tool for evaluation of platelet function measured by impedance aggregometry

Platelets, 2021
Platelet aggregation measured by impedance aggregometry is highly dependent on platelet count. We previously developed a tool to interpret impedance aggregometry based on the strong linear correlation between platelet counts and platelet aggregation at ...
Anna Schultz-Lebahn, Mette Tiedemann Skipper, Anne-Mette Hvas, Ole Halfdan Larsen   +3 more
doaj   +1 more source

Thrombin-induced platelet aggregation −effect of dabigatran using automated platelet aggregometry−

Platelets, 2020
Dabigatran, a direct oral thrombin inhibitor, has two therapeutic effects: anticoagulation; and antiplatelet activity. In the clinical field, evaluation of the effect of dabigatran on thrombin-induced platelet aggregation is difficult because of fibrin ...
Mie Shimizu, Tatsunori Natori, Keisuke Tsuda, Makiko Yoshida, Asami Kamada, Kiyotaka Oi, Yoko Ishigaku, Kazumasa Oura, Shinsuke Narumi, Masahiro Yamamoto, Yasuo Terayama   +10 more
doaj   +1 more source

The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential

Redox Biology, 2022
Protein disulfide isomerase (PDI), an oxidoreductase, possesses two vicinal cysteines in the -Cys-Gly-His-Cys-motif that either form a disulfide bridge (S–S) or exist in a sulfhydryl form (-SH), forming oxidized or reduced PDI, respectively. PDI has been
Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-chen Wang, Lei Wang   +6 more
doaj   +1 more source