Results 1 to 10 of about 218,065 (393)

Platelet aggregation inhibitors from hematophagous animals. [PDF]

Toxicon, 2010
Salivary glands from blood-sucking animals (e.g., mosquitoes, bugs, sand flies, fleas, ticks, leeches, hookworms, bats) are a rich source of bioactive molecules that counteract hemostasis in a redundant and synergistic manner. This review discusses recent progress in the identification of salivary inhibitors of platelet aggregation, their molecular ...
I. Francischetti
semanticscholar   +3 more sources

Effect of phosphodiesterase inhibitors on platelet function [PDF]

Biochemistry and Biophysics Reports
Phosphodiesterase enzymes (PDEs) play a pivotal role in regulating platelet activity by modulating intracellular levels of cAMP and cGMP. Modulation of PDE-2, -3 and -5 activity by suitable inhibitors has been found to reduce platelet activity, and thus ...
Ravi Hochuli, Valerie Dicenta, Zoi Laspa, Manuel Sigle, Tobias Harm, Tatsiana Castor, Anne-Katrin Rohlfing, Meinrad Paul Gawaz   +7 more
doaj   +2 more sources

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]

Platelets, 2019
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Amanda J. Unsworth, Alexander P. Bye, Neline Kriek, Tanya Sage, Ashley A. Osborne, Dillon Donaghy, Jonathan M. Gibbins   +6 more
doaj   +5 more sources

New platelet aggregation inhibitors.

Chemical and Pharmaceutical Bulletin, 1989
From a cultured broth of Streptomyces matensis A-6621, we isolated three new platelet aggregation inhibitors designated as PI-080, PI-085 and PI-087. The structures of these compounds were established by spectral and chemical methods.
A. Kawashima, Y. Kishimura, M. Tamai, K. Hanada   +3 more
semanticscholar   +5 more sources

Inhibition of platelet aggregation by protease inhibitors. Possible involvement of proteases in platelet aggregation. [PDF]

Blood, 1978
Abstract The possible participation of proteases in human platelet aggregation was explored using various protease inhibitors and substrates. Protease inhibitors used included naturally occurring inhibitors of serine proteases and synthetic inhibitors that modify the active site of protease.
N. Aoki, K. Naito, N. Yoshida
semanticscholar   +5 more sources

The Periprocedural Management of Anticoagulation and Platelet Aggregation Inhibitors in Endoscopic Interventions. [PDF]

Dtsch Arztebl Int, 2016
Lange CM, Fichtlscherer S, Miesbach W, Zeuzem S, Albert J.   +4 more
europepmc   +2 more sources

Effect of some inhibitors of platelet aggregation on platelet nucleotides [PDF]

Biochemical Journal, 1969
Ge. Ball, Megan Fulwood, Deborah Ireland, Patsy Yates   +3 more
openalex   +4 more sources

The perioperative management of treatment with anticoagulants and platelet aggregation inhibitors. [PDF]

Dtsch Arztebl Int, 2013
Schlitt A, Jámbor C, Spannagl M, Gogarten W, Schilling T, Zwissler B.   +5 more
europepmc   +2 more sources

Platelet aggregation inhibitors. I. Hydroxylamine: a potent inhibitor of platelet aggregation.

Chemical and Pharmaceutical Bulletin, 1972
K. Iizuka, K. Kikugawa
semanticscholar   +5 more sources

Platelet aggregation inhibitors in hot water extract of green tea.

Chemical and pharmaceutical bulletin, 1990
Y. Sagesaka-Mitane, M. Miwa, S. Okada
semanticscholar   +3 more sources