Results 1 to 10 of about 232,630 (413)

The perioperative management of treatment with anticoagulants and platelet aggregation inhibitors. [PDF]

Dtsch Arztebl Int, 2013
When giving anticoagulants and inhibitors of platelet aggregation either prophylactically or therapeutically, physicians face the challenge of protecting patients from thromboembolic events without inducing harmful bleeding. Especially in the perioperative period, the use of these drugs requires a carefully balanced evaluation of their risks and ...
Schlitt A, Jámbor C, Spannagl M, Gogarten W, Schilling T, Zwissler B.   +5 more
europepmc   +6 more sources

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]

Platelets, 2019
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Amanda J. Unsworth, Alexander P. Bye, Neline Kriek, Tanya Sage, Ashley A. Osborne, Dillon Donaghy, Jonathan M. Gibbins   +6 more
doaj   +5 more sources

A novel role of sesamol in inhibiting NF-κB-mediated signaling in platelet activation [PDF]

Journal of Biomedical Science, 2011
Background Platelet activation is relevant to a variety of coronary heart diseases. Our previous studies revealed that sesamol possesses potent antiplatelet activity through increasing cyclic AMP formation.
Chang Chao-Chien, Lu Wan-Jung, Ong Eng-Thiam, Chiang Cheng-Wen, Lin Song-Chow, Huang Shih-Yi, Sheu Joen-Rong   +6 more
doaj   +5 more sources

Effect of some inhibitors of platelet aggregation on platelet nucleotides [PDF]

Biochemical Journal, 1969
Ge. Ball, Megan Fulwood, Deborah Ireland, Patsy Yates   +3 more
openalex   +4 more sources

A New Shear-Stress-Based Point-of-Care Technology for Evaluation of the Hemostatic Pattern in Whole Blood [PDF]

Biosensors
The currently available point-of-care hemostasis tests are burdened by criticisms concerning the use of different activators and inhibitors and the lack of dynamic flow.
Alessandro Foladore, Simone Lattanzio, Elisabetta Lombardi, Cristina Durante, Ekaterina Baryshnikova, Martina Anguissola, Lidia Rota, Marco Ranucci, Mario Mazzucato   +8 more
doaj   +2 more sources

Comparative Study of Ex Vivo Antiplatelet Activity of Aspirin and Cilostazol in Patients with Diabetes and High Risk of Cardiovascular Disease [PDF]

Endocrinology and Metabolism, 2022
Background The role of aspirin in primary cardiovascular disease prevention in patients with diabetes remains controversial. However, some studies have suggested beneficial effects of cilostazol on cardiovascular disease in patients with diabetes.
Sangmo Hong, Woo Je Lee, Cheol-Young Park   +2 more
doaj   +1 more source

Aprobation of platelet aggregation inhibitor from Echis multisquamatis snake venom in vitro, in vivo and ex vivo [PDF]

Biotechnologia Acta, 2023
Snake venom-derived platelet aggregation inhibitors can be promising antiplatelet medications that can allow to avoid the risk of bleeding and treatment resistance, particularly in aspirin-resistant patients.
Zhelavskyi M. A., Platonov M. O., Kucheryavyi Y. Р., Stohnii Y. M.   +3 more
doaj   +1 more source

Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse [PDF]

, 2011
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
BB Dawood, BF McAdam, BJ Whittle, C Baigent, C Bombardier, C Moore, C Patrono, C Patrono, C Patrono, C Tymvios, CM Potter, D Pratico, EM Antman, F Catella-Lawson, F Giuliano, F Giuliano, G Davi, Harald H. H. W. Schmidt, JA Mitchell, Jane A. Mitchell, JJ Talley, LK Jennings, Michael Emerson, MJ Cho, N Zidar, NA Flavahan, Nicholas S. Kirkby, Paul C. Armstrong, PC Armstrong, PM Kearney, RF Storey, RJ Gryglewski, S Cronberg, S Krishnamurthi, S Moncada, SP Jackson, T Grosser, TD Warner, TD Warner, TD Warner, Timothy D. Warner, TT Niemi, WB White, Zetty N. Zain   +43 more
core   +10 more sources

Metabolic plasticity in resting and thrombin activated platelets. [PDF]

PLoS ONE, 2015
Platelet thrombus formation includes several integrated processes involving aggregation, secretion of granules, release of arachidonic acid and clot retraction, but it is not clear which metabolic fuels are required to support these events.
Saranya Ravi, Balu Chacko, Hirotaka Sawada, Philip A Kramer, Michelle S Johnson, Gloria A Benavides, Valerie O'Donnell, Marisa B Marques, Victor M Darley-Usmar   +8 more
doaj   +1 more source

Low-dose and standard-dose ticagrelor compared with clopidogrel in patients with acute coronary syndromes: A cohort study from china

Frontiers in Cardiovascular Medicine, 2022
PurposePrevious trials have demonstrated that ticagrelor was superior to clopidogrel in acute coronary syndrome (ACS) patients. However, several recent studies showed that ticagrelor was associated with a significantly higher risk of bleeding compared ...
Wenxing Peng, Yunnan Zhang, Yunnan Zhang, Yang Lin   +3 more
doaj   +1 more source