The Periprocedural Management of Anticoagulation and Platelet Aggregation Inhibitors in Endoscopic Interventions. [PDF]
Dtsch Arztebl Int, 2016 BACKGROUND In Germany, more than half a million persons, most of them elderly, are under long-term treatment with anticoagulants. The approval of new oral anticoagulants and platelet aggregation inhibitors, as well as new data on periprocedural bridging ...
Lange CM +4 more
europepmc +2 more sources
The perioperative management of treatment with anticoagulants and platelet aggregation inhibitors. [PDF]
Dtsch Arztebl Int, 2013 BACKGROUND When giving anticoagulants and inhibitors of platelet aggregation either prophylactically or therapeutically, physicians face the challenge of protecting patients from thromboembolic events without inducing harmful bleeding.
Schlitt A +5 more
europepmc +2 more sources
Platelet aggregation inhibitors from hematophagous animals. [PDF]
Toxicon, 2010 Salivary glands from blood-sucking animals (e.g., mosquitoes, bugs, sand flies, fleas, ticks, leeches, hookworms, bats) are a rich source of bioactive molecules that counteract hemostasis in a redundant and synergistic manner. This review discusses recent progress in the identification of salivary inhibitors of platelet aggregation, their molecular ...
I. Francischetti
semanticscholar +3 more sources
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]
Platelets, 2019 The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Amanda J. Unsworth +6 more
doaj +5 more sources
New platelet aggregation inhibitors.
Chemical and Pharmaceutical Bulletin, 1989 From a cultured broth of Streptomyces matensis A-6621, we isolated three new platelet aggregation inhibitors designated as PI-080, PI-085 and PI-087. The structures of these compounds were established by spectral and chemical methods.
A. Kawashima +3 more
semanticscholar +5 more sources
Platelet aggregation inhibitors. I. Hydroxylamine: a potent inhibitor of platelet aggregation.
Chemical and Pharmaceutical Bulletin, 1972 Platelets have been known to function in the formation of thrombi and plug,2) and the key role of adenosine diphosphate (ADP) as an important initiator of platelet aggregation has been well docum.ented.3) A wide variety of compounds that inhibit platelet
K. Iizuka, K. Kikugawa
semanticscholar +5 more sources
Elderly patients are hyperresponsive to potent P2Y12 inhibitors [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Aging has recently been associated with increased basal platelet activation and platelet hyperreactivity in response to adenosine diphosphate (ADP) but with decreased platelet response to thrombin receptor stimulation in individuals without ...
David Mutschlechner +7 more
doaj +2 more sources
Inhibition of platelet aggregation by protease inhibitors. Possible involvement of proteases in platelet aggregation. [PDF]
Blood, 1978 The possible participation of proteases in human platelet aggregation was explored using various protease inhibitors and substrates. Protease inhibitors used included naturally occurring inhibitors of serine proteases and synthetic inhibitors that modify
N. Aoki, K. Naito, N. Yoshida
semanticscholar +5 more sources
Platelet aggregation inhibitors in hot water extract of green tea.
Chemical and pharmaceutical bulletin, 1990 The effect of hot water extract of green tea on the collagen-induced aggregation of washed rabbit platelets was examined. The extract lowered submaximal aggregation and prolonged the lag time in a dose-dependent manner. After fractionation of the extract,
Y. Sagesaka-Mitane, M. Miwa, S. Okada
semanticscholar +3 more sources
Unbiased high-throughput screening of drug-repurposing libraries identifies small-molecule inhibitors of clot retraction [PDF]
Blood Advances: Platelet clot retraction, the ultimate phase of platelet thrombus formation, is critical for clot stabilization. It requires functional αIIbβ3 receptors, fibrin, and the integrated actions of the actin-myosin contractile and cytoskeletal systems ...
Lorena Buitrago +7 more
doaj +2 more sources