Platelet aggregation inhibitors in a Bhutanese medicinal plant, shug chher.
Chemical and pharmaceutical bulletin, 1993 The 90% methanol-soluble fraction of a Bhutanese medicinal plant, Shug Chher, exhibited inhibition of platelet aggregation induced by platelet activating factor.
K. Kagawa +8 more
semanticscholar +3 more sources
A novel role of sesamol in inhibiting NF-κB-mediated signaling in platelet activation [PDF]
Journal of Biomedical Science, 2011 Background Platelet activation is relevant to a variety of coronary heart diseases. Our previous studies revealed that sesamol possesses potent antiplatelet activity through increasing cyclic AMP formation.
Chang Chao-Chien +6 more
doaj +5 more sources
Effect of some inhibitors of platelet aggregation on platelet nucleotides [PDF]
Biochemical Journal, 1969 Ge. Ball +3 more
openalex +4 more sources
Fucosylated Glycosaminoglycan Oligosaccharide HS14, Derived from Sea Cucumbers, Is a Novel Inhibitor of Platelet Toll-like Receptor 2 [PDF]
Marine Drugs(1) Background: Toll-like receptor 2 (TLR2) on platelets is increasingly recognized as a pivotal mediator in infection-induced platelet activation and aggregation, contributing to both inflammatory and thrombotic diseases.
Huifang Sun +8 more
doaj +2 more sources
Comparative Study of Ex Vivo Antiplatelet Activity of Aspirin and Cilostazol in Patients with Diabetes and High Risk of Cardiovascular Disease [PDF]
Endocrinology and Metabolism, 2022 Background The role of aspirin in primary cardiovascular disease prevention in patients with diabetes remains controversial. However, some studies have suggested beneficial effects of cilostazol on cardiovascular disease in patients with diabetes.
Sangmo Hong +2 more
doaj +1 more source
Aprobation of platelet aggregation inhibitor from Echis multisquamatis snake venom in vitro, in vivo and ex vivo [PDF]
Biotechnologia Acta, 2023 Snake venom-derived platelet aggregation inhibitors can be promising antiplatelet medications that can allow to avoid the risk of bleeding and treatment resistance, particularly in aspirin-resistant patients.
Zhelavskyi M. A. +3 more
doaj +1 more source
Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse [PDF]
, 2011 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
BB Dawood +43 more
core +11 more sources
Metabolic plasticity in resting and thrombin activated platelets. [PDF]
PLoS ONE, 2015 Platelet thrombus formation includes several integrated processes involving aggregation, secretion of granules, release of arachidonic acid and clot retraction, but it is not clear which metabolic fuels are required to support these events.
Saranya Ravi +8 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 PurposePrevious trials have demonstrated that ticagrelor was superior to clopidogrel in acute coronary syndrome (ACS) patients. However, several recent studies showed that ticagrelor was associated with a significantly higher risk of bleeding compared ...
Wenxing Peng +3 more
doaj +1 more source
The search of compounds with antiaggregation activity among S-esters of thiosulfonic acids [PDF]
The Ukrainian Biochemical Journal, 2015 According to the current understanding, the hyperactivation of platelets may lead to increased intravascular coagulation and thrombosis. Today a relevant issue is the search for new anti-thrombotic agents that are able to modulate the activity of ...
T. I. Halenova +8 more
doaj +1 more source