Results 11 to 20 of about 47,830 (314)

An Aorta Intima Inhibitor of Platelet Aggregation [PDF]

Thrombosis and Haemostasis, 1977
The interaction of platelets and the vessel wall is of importance in the pathogenesis of intravascular thrombosis and atherosclerosis. We have previously described the presence of an inhibitor of platelet aggregation and a low Km ADPase in aorta intima extracts.
A. duP. Heyns, C. J. Badenhorst, Francois P. Retief   +2 more
openaire   +1 more source

Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes

Folia Medica, 2018
Background: Cyclic AMP is a powerful inhibitor of platelet aggregation. In the present study we examined the effect of platelet aggregation modulators on cyclic AMP content in human thrombocytes.
Boyanov Krasimir O., Maneva Ana I.
doaj   +1 more source

Comparison of the GPVI inhibitors losartan and honokiol

Platelets, 2020
Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly
Marie-Blanche Onselaer, Magdolna Nagy, Chiara Pallini, Jeremy A Pike, Gina Perrella, Lourdes Garcia Quintanilla, Johannes A Eble, Natalie S. Poulter, Johan W.M. Heemskerk, Steve P Watson   +9 more
doaj   +1 more source

Effects of the Btk-Inhibitors Remibrutinib (LOU064) and Rilzabrutinib (PRN1008) With Varying Btk Selectivity Over Tec on Platelet Aggregation and in vitro Bleeding Time

Frontiers in Cardiovascular Medicine, 2021
Background: Bruton tyrosine kinase inhibitors (BTKi) are used in B-cell malignancies and in development against various autoimmune diseases. Since Btk is also involved in specific pathways of platelet activation, BTKi might be considered to target ...
Rundan Duan, Luise Goldmann, Richard Brandl, Michael Spannagl, Christian Weber, Christian Weber, Christian Weber, Wolfgang Siess, Wolfgang Siess, Philipp von Hundelshausen, Philipp von Hundelshausen   +10 more
doaj   +1 more source

New platelet aggregation inhibitors.

Chemical and Pharmaceutical Bulletin, 1989
From a cultured broth of Streptomyces matensis A-6621, we isolated three new platelet aggregation inhibitors designated as PI-080, PI-085 and PI-087. The structures of these compounds were established by spectral and chemical methods.
Akira Kawashima, Kazunori Hanada, Yuko Kishimura, Masaharu Tamai   +3 more
openaire   +4 more sources

The effect of P2Y12 inhibition on platelet activation assessed with aggregation- and flow cytometry-based assays

Platelets, 2017
Patients on P2Y12 inhibitors may still develop thrombosis or bleeding complications. Tailored antiplatelet therapy, based on platelet reactivity testing, might reduce these complications.
Tesse C. Leunissen, Peter Paul Wisman, Thijs C. van Holten, Philip G. de Groot, Suzanne J. Korporaal, Arnold C. Koekman, Frans L. Moll, Martin Teraa, Marianne C. Verhaar, Gert Jan de Borst, Rolf T. Urbanus, Mark Roest   +11 more
doaj   +1 more source

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica)

Molecules, 2020
Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet
Nuntouchaporn Hutachok, Pongsak Angkasith, Chaiwat Chumpun, Suthat Fucharoen, Ian J. Mackie, John B. Porter, Somdet Srichairatanakool   +6 more
doaj   +1 more source

Platelet Activation and Aggregation Induced by Streptococcus bovis/Streptococcus equinus Complex

Microbiology Spectrum, 2022
Streptococcus bovis/Streptococcus equinus complex (SBSEC) is a common cause of infective endocarditis (IE). For IE-pathogens, the capacity to activate and aggregate platelets is believed to be an important virulence mechanism.
Gustav Pernow, Oonagh Shannon, Jonas Öberg, Bo Nilson, Magnus Rasmussen   +4 more
doaj   +1 more source

Metabolic plasticity in resting and thrombin activated platelets.

PLoS ONE, 2015
Platelet thrombus formation includes several integrated processes involving aggregation, secretion of granules, release of arachidonic acid and clot retraction, but it is not clear which metabolic fuels are required to support these events.
Saranya Ravi, Balu Chacko, Hirotaka Sawada, Philip A Kramer, Michelle S Johnson, Gloria A Benavides, Valerie O'Donnell, Marisa B Marques, Victor M Darley-Usmar   +8 more
doaj   +1 more source

Purification and characterization of platelet aggregation inhibitor from the Gloydius blomhoffii brevicaudus venom

Біологічні студії, 2012
Gloydius venom is a rich natural source of proteins possessing platelet aggregation inhibition activity. These proteins or their recombinant analogs are universal instruments for the investigation of proteins and receptors interaction in hemostatic ...
A. I. Zhukova, G. L. Volkov
doaj   +1 more source