Results 211 to 220 of about 222,697 (389)

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

Monomeric and Oligomeric Decorsins of the Asian Medicinal Leech <i>Hirudinaria manillensis</i>. [PDF]

Int J Mol Sci
Tolksdorf C, Wolf R, Rauch BH, Jedlitschky G, Müller C.   +4 more
europepmc   +1 more source

PI-200 and PI-201, new platelet aggregation inhibitors produced by Streptomyces sp. A7498. Taxonomy, fermentation, isolation, physico-chemical properties, structure determination and biological properties.

, 1992
Yuko Kishimura, Akira Kawashima, Terumi Kagamizono, Michio Yamagishi, Keita Matsumoto, Y. Kawashima, Kazunori Hanada   +6 more
openalex   +2 more sources

Aprotinin Inhibits Protease-Dependent Platelet Aggregation and Thrombosis [PDF]

, 2005
Tanveer Khan, Cesario Bianchi, Pierre Voisine, Jennifer L. Sandmeyer, Jun Feng, Frank W. Sellke   +5 more
openalex   +1 more source

Platelet aggregation inhibitors and inotropic constituents in Pyrolae herba.

Chemical and pharmaceutical bulletin, 1992
K. Kagawa, K. Tokura, K. Uchida, H. Kakushi, T. Shike, H. Nakai   +5 more
semanticscholar   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Proprotein Convertase Subtilisin/Kexin Type 9 Induces Platelet-Derived Transforming Growth Factor-<i>β</i> to Promote Myocardial Fibrosis After Myocardial Infarction. [PDF]

Hum Mutat
Wang Q, Huang W, Xia D, Wang F, Nair S.
europepmc   +1 more source

Study of a new thromboxane synthetase inhibitor CS-518 oral administration for platelet aggregation inhibitory effect.Comparison between PRP method and whole blood method.

, 1992
KAZUHITO KOSUGA
openalex   +2 more sources

Purification, Cloning, Expression, and Mechanism of Action of a Novel Platelet Aggregation Inhibitor from the Salivary Gland of the Blood-sucking Bug, Rhodnius prolixus [PDF]

, 2000
Ivo M.B. Francischetti, José M. C. Ribeiro, Donald E. Champagne, John F. Andersen   +3 more
openalex   +1 more source

Potato lectin: a modular protein sharing sequence similarities with the extensin family, the hevein lectin family, and snake venom disintegrins (platelet aggregation inhibitors).

The Plant Journal, 1994
M. Kieliszewski, A. Showalter, J. Leykam
semanticscholar   +1 more source