Results 221 to 230 of about 222,697 (389)

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Receptor-Dependent and -Independent Effects of Hemin on Platelet Plasma Membrane Disintegration. [PDF]

FASEB J
Laspa Z, Rohlfing AK, Hochuli R, Sowa PW, Castor T, Gawaz MP.   +5 more
europepmc   +1 more source

Platelet aggregation inhibitors. X. S-substituted 2-thioadenosines and their derivatives.

, 1977
Kiyomi Kikugawa, H. SUEHIRO, Akiji Aoki
openalex   +2 more sources

Platelet aggregation inhibitors in a Bhutanese medicinal plant, shug chher.

Chemical and pharmaceutical bulletin, 1993
K. Kagawa, K. Tokura, Kiyohisa Uchida, H. Kakushi, T. Shike, Junko Kikuchi, Hiroshi Nakai, Pema Dorji, Loknath Subedi   +8 more
semanticscholar   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Chrysoeriol Exerts Antiplatelet Effects by Regulating cAMP/cGMP and PI3K/MAPK Pathway. [PDF]

Biomol Ther (Seoul)
Lee GH, Lee JP, Wahab AA, Heo NY, Park CE, Lee DH.   +5 more
europepmc   +1 more source

1,4-Benzoxazine-3(4<i>H</i>)-ones as Potent Inhibitors of Platelet Aggregation: Design, Synthesis and Structure–Activity Relations

, 2014
Chang Liu, Jia‐Lian Tan, Siyu Xiao, Jie-Feng Liao, Guang-Rong Zou, Xi-Xi Ai, Jianbin Chen, Yi Xiang, Quan Yang, Hua Zuo   +9 more
openalex   +2 more sources

Synthesis of manool-related labdane diterpenes as platelet aggregation inhibitors.

Chemical and pharmaceutical bulletin, 1993
K. Yasui, K. Kawada, K. Kagawa, K. Tokura, K. Kitadokoro, Y. Ikenishi   +5 more
semanticscholar   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Mechanisms of Satigrel (E5510), a New Anti-platelet Drug, in Inhibiting Human Platelet Aggregation. Selectivity and Potency against Prostaglandin H Synthases Isozyme Activities and Phosphodiesterase Isoform Activities.

, 1996
N. Nagakura, T. Saeki, K Harada, Shinji Yoshitake, Seiichi Kobayashi, Takashi Yamanaka, Isao Saito   +6 more
openalex   +2 more sources