Advanced Science, EarlyView.The nanosized covalent organic polymer composed of photosensitizer porphyrin, pyruvate kinase inhibitor vitamin K3, and STAT3 inhibitor WP1066 is prepared for enhanced photodynamic immunotherapy by simultaneous hypoxia relief and STAT3 inhibition. Abstract Photodynamic therapy (PDT) is a promising cancer therapy modality by generating reactive oxygen ...
Lei Lei +7 more
wiley +1 more source
Recent advances in vascular thiol isomerases: insights into structures, functions in thrombosis and antithrombotic inhibitor development. [PDF]
Thromb JJiang L, Yuan C, Flaumenhaft R, Huang M.
europepmc +1 more source
Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy
Advanced Science, EarlyView.Cryo‐inactivated cancer cell‐based magnetic micromotors are developed for synergistic tumor immunotherapy via magnetic targeting. These micromotors can induce ferroptosis and immunogenic cell death, deliver tumor antigens, and activate the Mn2+‐dependent cGAS‐STING pathway. The system effectively suppresses tumor progression, recurrence, and metastasis,
Qingfei Zhang +3 more
wiley +1 more source
Bridging inflammation and venous thrombosis: the NLRP3 inflammasome connection. [PDF]
Front Cardiovasc MedWu J, Wang Z, Shao W, Mo J.
europepmc +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Dihydrogeodin from <i>Fennellia flavipes</i> Modulates Platelet Aggregation via Downregulation of Calcium Signaling, αIIbβ<sub>3</sub> Integrins, MAPK, and PI3K/Akt Pathways. [PDF]
Mar DrugsAkram AW +6 more
europepmc +1 more source
C1 inhibitor (C1 INH) and platelet aggregation.
Haematologica, 1988 COPPOLA L +3 more
openaire +2 more sources
Advanced Science, EarlyView.DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan +4 more
wiley +1 more source
Protective effects of combined eptifibatide and ticagrelor in patients with unstable angina undergoing percutaneous coronary intervention: a single-center experience. [PDF]
BMC Cardiovasc DisordShi S, Ling Z, Gu S, Jiang T, Ling L.
europepmc +1 more source
Case Report: Anti-platelet factor 4 -mediated immunothrombosis in a patient with ANCA vasculitis - a shared mechanism of NETosis. [PDF]
Front ImmunolRemez-Gabay L +3 more
europepmc +1 more source