Results 261 to 270 of about 47,830 (314)

Oral P2Y₁₂ Inhibitors: Victims or Perpetrators? A Focused Review on Pharmacokinetic, Clinically Relevant Drug Interactions. [PDF]

Eur Cardiol
Bigagli E, Angelini J, Mugelli A, Rocca B.   +3 more
europepmc   +1 more source

Platelet aggregation and its modulation using antithrombotic agents. [PDF]

Bioinformation
Srivastava N, Ghanshyambhai Khatrani K, Yagnik Tank B, Prafulchandra Tank Y, Bachwani U, Purohit KA.   +5 more
europepmc   +1 more source

A Novel KGD-Based αIIbβ3 Antagonist Prevents Arterial Thrombosis While Preserving Hemostasis and Avoiding Thrombocytopenia. [PDF]

Int J Mol Sci
Kuo YJ, Chung CH, Chen CC, Liu JC, Chiou KR, Sheu JR, Chuang WJ, Huang TF.   +7 more
europepmc   +1 more source

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Prostaglandins as Inhibitors of Human Platelet Aggregation

British Journal of Haematology, 1979
Summary. The potencies of prostaglandins (PG) I2, PGD2 and PGE1 as inhibitors of human platelet aggregation induced by threshold concentrations of four aggregating agents were determined in platelet‐rich plasma from normal individuals who had not ingested aspirin. The order of activity against ADP, adrenaline and collagen was always PGI2 > PGD2 >
DI MINNO, GIOVANNI, Silver MJ, de Gaetano G.   +2 more
openaire   +4 more sources

Disposition of anagrelide, an inhibitor of platelet aggregation

Clinical Pharmacology and Therapeutics, 1981
A single dose of 14C-anagrelide (6,7-dichloro-1,5-dihydroimidazo [2,1-b] quinazoline-2(3H)-one monohydrochloride) equivalent to 1 mg free base and containing 100 muCi radioactivity, was taken by five healthy, fasting men. Blood, plasma, urine, and feces were analyzed for total radioactivity. Plasma and urine concentrations of anagrelide were determined,
Kenneth A. Pittman, Robert D. Smyth, George Deeb, Robert C. Gaver   +3 more
openaire   +3 more sources

Inhibitors of platelet aggregation from onion

Phytochemistry, 1990
Abstract Five new sulphur-containing compounds and five diastereoisomers which indicated potent inhibitory efrects for collagen-induced aggregation of human platelets in vitro as well as ADP- or arachidonate-induced aggregation were isolated from onion. All isolated compounds have a 1-(methylsulphinyl)-propyl alkyl (or alkenyl) disulphide skeleton.
Yasujiro Morimitsu, Shunro Kawakishi
openaire   +2 more sources

Hypopigmentation in Dogs Treated with an Inhibitor of Platelet Aggregation

Toxicologic Pathology, 1989
Hypopigmentation was the principal manifestation of systemic toxicity when the experimental platelet aggregation inhibitor, PD-89454, was orally administered to Beagle dogs for 28 days. Pigmentation changes were present in skin of nose, lips and eyelids and mucosa of hard palate.
Alexander W. Gough, Kathleen M. Walsh
openaire   +3 more sources

Platelet aggregation inhibitors in neurology

Pharmacy World & Science, 1993
This literature review reports on secondary prevention of ischaemic stroke. The aim of secondary prevention is to protect patients who belong to a risk group from the occurrence of brain infarction. Symptomatic patients with a demonstrated carotid artery stenosis of 70% and more will most probably benefit from carotid endarterectomy if performed by a ...
openaire   +3 more sources

Inhibitors of “spontaneous” platelet aggregation in whole blood

Atherosclerosis, 1985
In vitro 'spontaneous' platelet aggregation has been studied in whole blood. The spectrum of activity of materials known to influence platelet aggregation in platelet-rich plasma proved different in whole blood. Thus dipyridamole and one of its analogues SH1242 had a striking effect in whole blood whilst aspirin, chlorpromazine and K3920 had little or ...
E. Weisblatt, M. Steiner, S.S. Pollock, M.J.G. Harrison   +3 more
openaire   +3 more sources