Results 261 to 270 of about 222,697 (389)

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Antithrombotic Polymers: A Narrative Review on Current and Future Strategies for Their Design, Synthesis, and Application. [PDF]

Int J Mol Sci
Smola-Dmochowska A, Śmigiel-Gac N, Jelonek K, Lewicka-Brzoza K, Bojdol J, Dobrzyński P.   +5 more
europepmc   +1 more source

C1 inhibitor (C1 INH) and platelet aggregation.

Haematologica, 1988
COPPOLA L, VERRAZZO G, GIUNTA, Riccardo, TIRELLI, Armando   +3 more
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Comparative study of four platelet function tests conducted using two systems in neuroendovascular patients. [PDF]

Sci Rep
Sakayori T, Nakanishi R, Shoda K, Ueno Y, Kanbe A, Oka A, Mizutani D, Kitano K, Kikuchi R, Enomoto Y.   +9 more
europepmc   +1 more source

Therapeutic effects of ticlopidine, a new inhibitor of platelet aggregation, on chronic arterial occlusive diseases

, 1980
Tatsuki Katsumura, Akira Kusaba, Shigehiko Shionoya, Kisaku Kamiya, Yoshio Mishima, Yoshimasa Miyauchi, Akio Nishimura   +6 more
openalex   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

BTK inhibitors potently impair platelet aggregation as a class effect independent of BTK specificity or dose in CLL and MCL. [PDF]

J Clin Exp Hematop
Kojima K, Watanabe S, Takeuchi A, Kunisawa N, Yoshida S.   +4 more
europepmc   +1 more source

An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis

Advanced Science, EarlyView.
Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang, Jianming Yan, Tongxin Yu, Zichuan An, Kaikai Lv, Chenyu Xue, Hongyang Yu, Na Dong, Anshan Shan   +8 more
wiley   +1 more source

Platelet inhibition delays time to neurosurgical intervention for cerebral metastasis in non-small cell lung cancer. [PDF]

Sci Rep
Wasilewski D, Onken J, Won SY, Rafaelian A, Hempelmann A, Bernstock J, Maletzki C, Freiman T, Vajkoczy P, Gessler F, Dubinski D.   +10 more
europepmc   +1 more source