Results 271 to 280 of about 47,830 (314)

Cardamom extract as inhibitor of human platelet aggregation

Phytotherapy Research, 2005
The inhibitory activity of cardamom extract was studied on human platelets. Platelet aggregation and lipid peroxidation were evaluated with platelet rich plasma (PRP) and platelet membranes, respectively, obtained from blood of healthy volunteers.
W. Jessie Suneetha, T. P. Krishnakantha
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In Vitro Evaluation of Inhibitors of Platelet Release and Aggregation

Archives of Surgery, 1975
In order to determine which drugs would be most effective as inhibitors of platelet release and aggregation, in vitro release reactions and platelet aggregometry were used to evaluate aspirin, dipyridamole, sulfinpyrazone, flurbiprofen, low molecular weight dextran (dextran 40), prostaglandin E1 (PGE1), apyrase, and adenosine.
J. C. Rosenberg, Thomas L. Sell
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New pyridazinone derivatives as inhibitors of platelet aggregation

European Journal of Medicinal Chemistry, 1995
Summary The synthesis and evaluation of the biological activity of a series of 3(2 H )-pyridazinone derivatives is reported. We assessed the in vitro activity of these compounds on aggregation and production of thromboxane A 2 and prostaglandin E 2 of human platelets.
S. Corsano, R. Vezza, R. Scapicchi, S. Foresi, G. Strappaghetti, NENCI, Giuseppe Giorgio, GRESELE, Paolo   +6 more
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Process Development of a Platelet Aggregation Inhibitor

Organic Process Research & Development, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Thienopyrimidine-based P2Y12 platelet aggregation inhibitors

Bioorganic & Medicinal Chemistry Letters, 2009
Herein we describe the design and synthesis of a novel series of potent thienopyrimidine P2Y12 inhibitors and the negative impact protein binding has on the inhibition of platelet aggregation.
Tenbrink Ruth E, Steven W. Kortum, Barbara A. Schweitzer, Rhonda M. Lachance, Ennis Michael D, Gopichand Yalamanchili, Hayat K. Rahman, Rita M. Huff   +7 more
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Lebetin Peptides: Potent Platelet Aggregation Inhibitors

Pathophysiology of Haemostasis and Thrombosis, 2001
Lebetins from <i>Macrovipera lebetina</i> snake venom constitute a new class of inhibitors of platelet aggregation. There are two groups of peptides: lebetin 1 (L1; 11- to 13-mer) and lebetin 2 (L2; 37- to 38-mer). The short lebetins are identical to the N-terminal segments of the longer ones.
M. El Ayeb, Hervé Rochat, Mohamed Fathallah, Imed Regaya, N. Marrakchi, Kamel Mabrouk, Sameh Sarray   +6 more
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Bleeding in a Patient Receiving Platelet Aggregation Inhibitors

Anesthesia & Analgesia, 2001
We describe a patient who experienced intraoperative bleeding after being treated with platelet receptor glycoprotein IIb/IIIa antagonist eptifibatide. We used Sonoclot and Thrombelastograph to monitor antiplatelet effects of eptifibatide.
Jonathan H. Waters, Juraj Sprung, Alexandru Gottlieb, David G. Anthony   +3 more
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Effect of Inhibitors of Aggregation on Platelet Ultrastructure in Vitro

Thrombosis and Haemostasis, 1969
SummaryElectron microscopy observations are presented on the effect of inhibitors of aggregation on platelet morphology. Moreover the relationship existing between shape changes produced by inhibitors of platelet aggregation and the mechanism of inhibition has also been studied.Among the inhibitors, nucleotides were without effect on platelet shape, so
Sirigu F, Mannucci Pm
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New carbamoylpiperidines as human platelet aggregation inhibitors

Bioorganic & Medicinal Chemistry, 2000
A series of 3-carbamoylpiperidines (nipecotamides) are designed, synthesized and tested for their inhibitory action against adenosine diphosphate (ADP)-induced aggregation of human platelets. A structure-activity analysis of the bis(nipecotamido)aralkane type showed that a substituent on the piperidine ring should preferably be an amide and that the ...
Walter B. Thompson, Marion Dugdale, Ram Gollamudi, Xiaozhang Zheng, Zhengming Guo   +4 more
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Platelet turnover in metastatic cancer and the effect of platelet aggregation inhibitors [PDF]

Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1976
Patients with metastatic cancer have a permanent shortening of platelet survival and increased platelet consumption. Acetylsalicylic acid or dipyridamole in doses known to inhibit platelet aggregation, had no effect on platelet consumption.
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