Results 41 to 50 of about 237,328 (413)

Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis [PDF]

J. Thromb. Haemost. 2009 (7), 2096-2105, 2009
To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a shear flow dependent manner. We examined if tensile stress in VWF under shear flow activates the VWF A2 domain for cleavage by ADAMTS13 using molecular dynamics simulations.
arxiv   +1 more source

Platelet aggregation inhibitors, vitamin K antagonists and risk of subarachnoid hemorrhage

Journal of Thrombosis and Haemostasis, 2011
Summary.  Background: Use of platelet aggregation inhibitors and vitamin K antagonists has been associated with an increased risk of intracranial hemorrhage (ICH).
R. Risselada, H. Straatman, F. Kooten, D. Dippel, A. Lugt, W. Niessen, W. Niessen, A. Firouzian, Ron M. C. Herings, M. Sturkenboom   +9 more
semanticscholar   +1 more source

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica)

Molecules, 2020
Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet
Nuntouchaporn Hutachok, Pongsak Angkasith, Chaiwat Chumpun, Suthat Fucharoen, Ian J. Mackie, John B. Porter, Somdet Srichairatanakool   +6 more
doaj   +1 more source

Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction [PDF]

, 2019
Aims: Despite widespread use of dual antiplatelet therapy in acute myocardial infarction, there remains a residual risk of morbidity and mortality.
Ayton, Sarah, Bhatti, Maria, Bowles, Kristian, Flather, Marcus, Geisler, Tobias, Gollop, Nicholas D., Michail, Olga, Rushworth, Stuart, Ryding, Alisdair   +8 more
core   +1 more source

Purification and characterization of platelet aggregation inhibitor from the Gloydius blomhoffii brevicaudus venom

Біологічні студії, 2012
Gloydius venom is a rich natural source of proteins possessing platelet aggregation inhibition activity. These proteins or their recombinant analogs are universal instruments for the investigation of proteins and receptors interaction in hemostatic ...
A. I. Zhukova, G. L. Volkov
doaj   +1 more source

Syk-dependent Phosphorylation of CLEC-2: A Novel Mechanism of Hem-Immunoreceptor Tyrosine-Based Activation Motif Signaling [PDF]

, 2010
The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM).
Eble, J. A., Mourao-Sa, D., Nash, C. A., Navarro-Nunez, L., Pollitt, A. Y., Senis, Y. A., Severin, S., Watson, Steve P   +7 more
core   +2 more sources

The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential

Redox Biology, 2022
Protein disulfide isomerase (PDI), an oxidoreductase, possesses two vicinal cysteines in the -Cys-Gly-His-Cys-motif that either form a disulfide bridge (S–S) or exist in a sulfhydryl form (-SH), forming oxidized or reduced PDI, respectively. PDI has been
Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-chen Wang, Lei Wang   +6 more
doaj  

Aggregation of human platelets by Tannerella Forsythia

Contemporary Clinical Dentistry, 2022
Context: Periodontitis is a persistent infection of the tissues surrounding the teeth characterized by inflamed microvasculature, and is associated with increased systemic platelet activation.
Eugene J Whitaker, Caitlin D Darcey, Susan M Somerset   +2 more
doaj   +1 more source

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source