Results 91 to 100 of about 34,180,212 (292)

Acetylcholine Inhibits Monomeric C-Reactive Protein Induced Inflammation, Endothelial Cell Adhesion, and Platelet Aggregation; A Potential Therapeutic?

Frontiers in Immunology, 2018
Objectives: In this study, we examined the possibility of using targeted antibodies and the potential of small molecular therapeutics (acetylcholine, nicotine and tacrine) to block the pro-inflammatory and adhesion-related properties of monomeric C ...
Mark Slevin, Mark Slevin, Mark Slevin, Rocco S. Iemma, Yasmin Zeinolabediny, Yasmin Zeinolabediny, Donghui Liu, Donghui Liu, Glenn R. Ferris, Vittorio Caprio, Nicola Phillips, Mario Di Napoli, Baoqiang Guo, Baoqiang Guo, Xianwei Zeng, Raid AlBaradie, Naif K. Binsaleh, Garry McDowell, Wen-Hui Fang   +18 more
doaj   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Effects of Computer Navigation versus Conventional Total Knee Arthroplasty on Endothelial Damage Marker Levels: A Prospective Comparative Study.

PLoS ONE, 2015
UnlabelledTotal knee arthroplasty (TKA) inevitably perturbs the femoral medullary canal, which increases blood loss or morbidities associated with marrow embolization postoperatively.
Shu-Jui Kuo, Feng-Sheng Wang, Ching-Jen Wang, Jih-Yang Ko, Sung-Hsiung Chen, Ka-Kit Siu   +5 more
doaj   +1 more source

Platelet endothelial cell adhesion molecule 1 (PECAM-1) and its interactions with glycosaminoglycans: 1. Molecular modeling studies

, 2008
Platelet endothelial cell adhesion molecule 1 (PECAM-1) has many functions, including its roles in leukocyte extravasation as part of the inflammatory response and in the maintenance of vascular integrity through its contribution to endothelial cell−cell
Mancera, Ricardo L., Coombe, Deidre, Coombe, Deirdre R., Gandhi, Neha, Mancera, Ricardo, Gandhi, Neha S.   +5 more
core   +1 more source

Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells [PDF]

, 2009
Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, <i>Nrp1</i> null embryos display vascular defects that differ from those of mice lacking ...
Caccavari, Francesca, Valdembri, D., Serini, G., Valdembri, Donatella, Caccavari, F., Caswell Patrick T, Anderson, K.I., Humphries, M.J., Patrick T Caswell, Anderson Kurt I, Anderson, Kurt I., Serini, Guido, Caccavari Francesca, Federico Bussolino, Elena Astanina, Valdembri Donatella, König, I., König, Ireen, Astanina, Elena, Schwarz, J.P., Francesca Caccavari, Jim C Norman, Humphries Martin J, Bussolino, F., Schwarz Juliane P, Guido Serini, Serini Guido, König Ireen, Schwarz, Juliane P., Bussolino, Federico, Kurt I Anderson, Humphries, Martin J., Caswell, Patrick T.; id_orcid, Norman, Jim C., Juliane P Schwarz, Astanina Elena, Astanina, E., Bussolino Federico, Norman, J.C., Donatella Valdembri, Caswell, P.T., Ireen König, Norman Jim C, Martin J Humphries   +43 more
core   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Islet Endothelial Cells Derived from Mouse Embryonic Stem Cells

Cell Transplantation, 2016
The islet endothelium comprises a specialized population of islet endothelial cells (IECs) expressing unique markers such as nephrin and α-1 antitrypsin (AAT) that are not found in endothelial cells in surrounding tissues. However, due to difficulties in
Neha Jain, Eun Jung Lee Ph.D.
doaj   +1 more source

Data on the circulating levels of endothelial microparticles are elevated in patients with bicuspid aortic valve and are related to aortic dilation

Data in Brief, 2016
The data included here support the research article “Circulating endothelial microparticles are elevated in bicuspid aortic valve (BAV) disease and related to aortic dilation” (Alegret et al., 2016 [1]) where circulating levels of platelet endothelial ...
Josep M. Alegret, Neus Martínez-Micaelo, Gerard Aragonès, Raúl Beltrán-Debón   +3 more
doaj   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Platelet endothelial cell adhesion molecule 1 (PECAM-1) and its interactions with glycosaminoglycans: 2. Biochemical analyses

, 2008
Platelet endothelial cell adhesion molecule 1 (PECAM-1) (CD31), a member of the immunoglobulin (Ig) superfamily of cell adhesion molecules with six Ig-like domains, has a range of functions, notably its contributions to leukocyte extravasation during ...
Osmond, R. I. W., Kinnear, Bev, Osmond, Ronald, Gandhi, Neha, Mancera, R. L., Stevenson, S. M., Gandhi, Neha S., Kett, Warren, Kinnear, B. F., Coombe, Deidre, Kett, W. C., Coombe, D. R., Mancera, Ricardo, Stevenson, Sandra   +13 more
core   +1 more source