Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction [PDF]
The Journal of Cell Biology, 2002 Fluid shear stress (FSS) induces many forms of responses, including phosphorylation of extracellular signal–regulated kinase (ERK) in endothelial cells (ECs).
M. Osawa +3 more
semanticscholar +2 more sources
Journal of Biological Chemistry, 1993 Platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a 130-kDa integral membrane glycoprotein expressed on endothelial cells, platelets, and leukocytes.
H. Delisser +9 more
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Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses [PDF]
PeerJ, 2017 Background 2′–4′ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine the role of ...
Merideth Early +5 more
doaj +3 more sources
Mechanism of Collaborative Enhancement of Binding of Paired Antibodies to Distinct Epitopes of Platelet Endothelial Cell Adhesion Molecule-1. [PDF]
PLoS ONE, 2017 Monoclonal antibodies (mAbs) directed to extracellular epitopes of human and mouse Platelet Endothelial Cell Adhesion Molecule-1 (CD31 or PECAM-1) stimulate binding of other mAbs to distinct adjacent PECAM-1 epitopes.
Raisa Kiseleva +9 more
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Blood, 2001 The functional importance of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) in platelets is unclear. Because PECAM-1 represents a newly assigned immunoglobulin–ITIM superfamily member expressed on the surface of platelets, it was hypothesized that it may play an important regulatory role in modulating ITAM-bearing receptors such as ...
K. L. Jones +5 more
semanticscholar +4 more sources
Platelet endothelial cell adhesion molecule‐1 is a major SH‐PTP2 binding protein in vascular endothelial cells [PDF]
FEBS Letters, 1997 Platelet endothelial cell adhesion molecule‐1 (PECAM‐1, CD31) is rapidly tyrosine phosphorylated in mechanically stimulated vascular endothelial cells (ECs). A 65‐kDa protein from ECs specifically bound to the c‐Src phosphorylated PECAM‐1 cytoplasmic domain and was identified as a protein tyrosine phosphatase SH‐PTP2 (SHP2, Syp).
M. Masuda +4 more
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Downregulating Platelet Endothelial Cell Adhesion Molecule‐1 Enhances Learning and Memory and Alleviates Hallmark Pathologies in Alzheimer's Disease [PDF]
MedCommAlzheimer's disease (AD) is a neurodegenerative disorder that currently lacks cures; thus, searching for new biomarkers and unraveling its underlying mechanisms are crucial for devising effective therapies.
Qiuzhi Zhou +17 more
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Effect of the cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on in vivo platelet activation, oxidative stress, and procoagulant responses induced by waterpipe smoke exposure in mice [PDF]
Frontiers in ToxicologyIntroductionExposure to waterpipe smoke (WPS) in humans and experimental animals has been reported to cause oxidative stress and thrombotic complications.
Sumaya Beegam +5 more
doaj +2 more sources
Crosstalk Between Reticular Adherens Junctions and Platelet Endothelial Cell Adhesion Molecule-1 Regulates Endothelial Barrier Function [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2012 Objective— Endothelial cells provide a barrier between the blood and tissues, which is reduced during inflammation to allow selective passage of molecules and cells. Adherens junctions (AJ) play a central role in regulating this barrier. We aim to investigate the role of a distinctive 3-dimensional reticular network of AJ found
Laura Fernández-Martín +11 more
semanticscholar +4 more sources
Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. [PDF]
Proceedings of the National Academy of Sciences, 1996 Platelet-endothelial cell adhesion molecule 1 (PECAM-1, CD31) is a 130-kDa member of the immunoglobulin gene superfamily expressed on endothelial cells, platelets, neutrophils, and monocytes and plays a role during endothelial cell migration. Phosphoamino acid analysis and Western blot analysis with anti-phosphotyrosine antibody show that endothelial ...
T. Lu, Linda G. Yan, J. Madri
semanticscholar +3 more sources