Results 221 to 230 of about 223,961 (265)

Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo.

Science, 1993
During inflammation, neutrophils migrate from the vascular lumen into extravascular sites. In vitro assays have suggested that platelet-endothelial cell adhesion molecule-1 [PECAM-1 (CD31)], a member of the immunoglobulin superfamily, is required for the transmigration of neutrophils across endothelial monolayers. Antibody to human PECAM-1, which cross-
A. Vaporciyan, H. Delisser, H. Yan, I. Mendiguren, S. Thom, M. Jones, P. Ward, S. Albelda   +7 more
semanticscholar   +3 more sources

Platelet-endothelial cell adhesion molecule-1

, 2004
L. Moreland
semanticscholar   +2 more sources

Platelet Endothelial Cell Adhesion Molecule-1 is a Gatekeeper of Neutrophil Transendothelial Migration in Ischemic Stroke.

Brain, behavior, and immunity, 2020
RATIONALE Adhesion molecules are key elements in stroke-induced brain injury by regulating the migration of effector immune cells from the circulation to the lesion site.
Jack Winneberger, S. Schöls, Katrin Lessmann, J. Rández-Garbayo, A. Bauer, A. Mohamud Yusuf, D. Hermann, M. Gunzer, S. Schneider, J. Fiehler, C. Gerloff, M. Gelderblom, P. Ludewig, T. Magnus   +13 more
semanticscholar   +1 more source

Platelet-Endothelial Cell Adhesion Molecule-1-Directed Immunotargeting to Cardiopulmonary Vasculature

The Journal of Pharmacology and Experimental Therapeutics, 2002
Therapeutic molecules conjugated with antibodies to the platelet-endothelial cell adhesion molecule-1 (PECAM-1) accumulate in the pulmonary endothelium after i.v. injection in mice. In this study, we characterized PECAM-directed targeting to the lung and heart after local versus systemic intravascular administration in a large animal model, pigs ...
Arnaud, Scherpereel, Jonathan J, Rome, Rainer, Wiewrodt, Simon C, Watkins, David Winslow, Harshaw, Sean, Alder, Melpo, Christofidou-Solomidou, Elliott, Haut, Juan-Carlos, Murciano, Marian, Nakada, Steven M, Albelda, Vladimir R, Muzykantov   +11 more
openaire   +2 more sources

Platelet endothelial cell adhesion molecule 1 deficiency misguides venous thrombus resolution

Blood, 2013
Key PointsPECAM-1 deficiency misguides venous thrombus resolution. PECAM-1 cell surface shedding occurs at the site of venous thrombosis.
Joerg, Kellermair, Bassam, Redwan, Sherin, Alias, Joerg, Jabkowski, Adelheid, Panzenboeck, Lukas, Kellermair, Max P, Winter, Ansgar, Weltermann, Irene M, Lang   +8 more
openaire   +2 more sources

Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation.

Journal of Immunology, 1996
Platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a glycoprotein expressed on the surfaces of monocytes, neutrophils, platelets, a subpopulation of T cells, and, as described in this work, on NK cells.
Miriam E. Berman, Yong Xie, Yong Xie, W. Muller   +3 more
semanticscholar   +1 more source

Tyrosine Phosphorylation of Platelet Endothelial Cell Adhesion Molecule-1 Induced by Lysophosphatidylcholine in Cultured Endothelial Cells

Biochemical and Biophysical Research Communications, 1998
Lysophosphatidylcholine (lyso-PC), a biologically active phospholipid, appears to modulate various endothelial cell functions through tyrosine kinase-dependent signaling pathways. In cultured bovine aortic endothelial cells (BAEC), we have found that a 130 kDa protein (p130) was rapidly tyrosine phosphorylated within 2 min and sustained for, at least ...
H, Ochi, N, Kume, E, Nishi, H, Moriwaki, M, Masuda, K, Fujiwara, T, Kita   +6 more
openaire   +2 more sources

Platelet endothelial cell adhesion molecule‐1 modulates endothelial cell motility through the small G‐protein Rho

The FASEB Journal, 2003
ABSTRACT Platelet endothelial cell adhesion molecule‐1 (PECAM‐1), an immunoglobulin family vascular adhesion molecule, is involved in endothelial cell migration and angiogenesis (1, 2). We found that endothelial cells lacking PECAM‐1 exhibit increased single cell motility and extension formation but poor wound ...
Dita, Gratzinger, Sandra, Canosa, Britta, Engelhardt, Joseph A, Madri   +3 more
openaire   +2 more sources

Nitric Oxide Mediates the Effect of Fluvastatin on Intercellular Adhesion Molecule-1 and Platelet Endothelial Cell Adhesion Molecule-1 Expression on Human Endothelial Cells

Annals of Vascular Surgery, 2005
Leukocyte and platelet adhesion to endothelial cells, an early step in the pathogenesis of atherosclerosis, is mediated through adhesion molecules. It has been shown that statins decrease adhesion molecule expression. We examined the hypothesis that fluvastatin decreased intercellular adhesion molecule-1 (ICAM-1) and platelet endothelial cell adhesion ...
Eleftherios S, Xenos, Scott L, Stevens, Michael B, Freeman, David C, Cassada, Mitchell H, Goldman   +4 more
openaire   +2 more sources

Role for Platelet-Endothelial Cell Adhesion Molecule-1 in Macrophage Fcγ Receptor Function

American Journal of Respiratory Cell and Molecular Biology, 2004
Platelet-endothelial cell adhesion molecule-1 (PECAM-1) (CD31), a 130-kD transmembrane glycoprotein that functions in adhesion and signaling, is thought to play a role in some forms of leukocyte transmigration. In the lung, PECAM-1 is highly expressed, yet there have been few studies examining its role in pulmonary pathology.
Steven M, Albelda, Kelvin C, Lau, Paul, Chien, Zhen-Yu, Huang, Eugenia, Arguiris, Alyssa, Bohen, Jing, Sun, Jessica A, Billet, Melpo, Christofidou-Solomidou, Zena K, Indik, Alan D, Schreiber   +10 more
openaire   +2 more sources