Results 251 to 260 of about 34,180,212 (292)

Platelet endothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactions

Blood, 2001
The functional importance of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) in platelets is unclear. Because PECAM-1 represents a newly assigned immunoglobulin–ITIM superfamily member expressed on the surface of platelets, it was hypothesized that it may play an important regulatory role in modulating ITAM-bearing receptors such as ...
Jones, K., Hughan, S., Dopheide, S., Farndale, R., Jackson, S., Jackson, D.   +5 more
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Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo

Science, 1993
During inflammation, neutrophils migrate from the vascular lumen into extravascular sites. In vitro assays have suggested that platelet-endothelial cell adhesion molecule-1 [PECAM-1 (CD31)], a member of the immunoglobulin superfamily, is required for the transmigration of neutrophils across endothelial monolayers. Antibody to human PECAM-1, which cross-
A A, Vaporciyan, H M, DeLisser, H C, Yan, I I, Mendiguren, S R, Thom, M L, Jones, P A, Ward, S M, Albelda   +7 more
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Platelet-Endothelial Cell Adhesion Molecule-1-Directed Immunotargeting to Cardiopulmonary Vasculature

The Journal of Pharmacology and Experimental Therapeutics, 2002
Therapeutic molecules conjugated with antibodies to the platelet-endothelial cell adhesion molecule-1 (PECAM-1) accumulate in the pulmonary endothelium after i.v. injection in mice. In this study, we characterized PECAM-directed targeting to the lung and heart after local versus systemic intravascular administration in a large animal model, pigs ...
Scherpereel, Arnaud, Rome, Jonathan J., Wiewrodt, Rainer, Watkins, Simon C., Winslow Harshaw, David, Alder, Sean, Christofidou-Solomidou, Melpo, Haut, Elliott, Murciano Fernández, Juan Carlos, Nakada, Marian, Albelda, Steven M., Muzykantov, Vladimir R.   +11 more
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Tyrosine Phosphorylation of Platelet Endothelial Cell Adhesion Molecule-1 Induced by Lysophosphatidylcholine in Cultured Endothelial Cells

Biochemical and Biophysical Research Communications, 1998
Lysophosphatidylcholine (lyso-PC), a biologically active phospholipid, appears to modulate various endothelial cell functions through tyrosine kinase-dependent signaling pathways. In cultured bovine aortic endothelial cells (BAEC), we have found that a 130 kDa protein (p130) was rapidly tyrosine phosphorylated within 2 min and sustained for, at least ...
H, Ochi, N, Kume, E, Nishi, H, Moriwaki, M, Masuda, K, Fujiwara, T, Kita   +6 more
openaire   +2 more sources

Nitric Oxide Mediates the Effect of Fluvastatin on Intercellular Adhesion Molecule-1 and Platelet Endothelial Cell Adhesion Molecule-1 Expression on Human Endothelial Cells

Annals of Vascular Surgery, 2005
Leukocyte and platelet adhesion to endothelial cells, an early step in the pathogenesis of atherosclerosis, is mediated through adhesion molecules. It has been shown that statins decrease adhesion molecule expression. We examined the hypothesis that fluvastatin decreased intercellular adhesion molecule-1 (ICAM-1) and platelet endothelial cell adhesion ...
Eleftherios S, Xenos, Scott L, Stevens, Michael B, Freeman, David C, Cassada, Mitchell H, Goldman   +4 more
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Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Polymorphisms

2021
During Plasmodium falciparum infection, cytoadherence, and rosetting are the main causes of pathology. Excessive cytoadherence and rosetting probably cause occlusion of the microvasculature, leading to acute pathology of severe malaria. Endothelial receptors including intercellular adhesion molecule-1 (ICAM-1), platelet endothelial cell adhesion ...
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Expression of platelet endothelial cell adhesion molecule-1 in red and black endometriotic lesions

Fertility and Sterility, 2004
This immunohistochemical study shows that platelet endothelial cell adhesion molecule-1 (PECAM-1), known to play a role in neoangiogenesis and vascular development, is strongly and homogeneously expressed in endothelial cells lining blood vessels from red and black pelvic endometriotic lesions.
Anne, Van Langendonckt, Julie, Eggermont, Françoise, Casanas-Roux, H Elène, Scholtes, Jacques, Donnez   +4 more
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Role for Platelet-Endothelial Cell Adhesion Molecule-1 in Macrophage Fcγ Receptor Function

American Journal of Respiratory Cell and Molecular Biology, 2004
Abstract Platelet-endothelial cell adhesion molecule-1 (PECAM-1) (CD31), a 130-kD transmembrane glycoprotein that functions in adhesion and signaling, is thought to play a role in some forms of leukocyte transmigration. In the lung, PECAM-1 is highly expressed, yet there have been few studies examining its role in pulmonary pathology.
Steven M, Albelda, Kelvin C, Lau, Paul, Chien, Zhen-Yu, Huang, Eugenia, Arguiris, Alyssa, Bohen, Jing, Sun, Jessica A, Billet, Melpo, Christofidou-Solomidou, Zena K, Indik, Alan D, Schreiber   +10 more
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Platelet endothelial cell adhesion molecule 1 deficiency misguides venous thrombus resolution

Blood, 2013
Key PointsPECAM-1 deficiency misguides venous thrombus resolution. PECAM-1 cell surface shedding occurs at the site of venous thrombosis.
Joerg, Kellermair, Bassam, Redwan, Sherin, Alias, Joerg, Jabkowski, Adelheid, Panzenboeck, Lukas, Kellermair, Max P, Winter, Ansgar, Weltermann, Irene M, Lang   +8 more
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Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen

Blood, 2001
Platelet responses to collagen are mediated by the combined actions of the integrin α2β1, which serves as a major collagen-binding receptor, and the GPVI/FcRγ-chain complex, which transmits collagen-specific activation signals into the cell interior through the action of an immunoreceptor tyrosine-based activation motif within the cytoplasmic domain of
S, Patil, D K, Newman, P J, Newman
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