Results 51 to 60 of about 223,961 (265)

Regulation of platelet biology by platelet endothelial cell adhesion molecule-1

Platelets, 2011
Platelet endothelial cell adhesion molecule-1 (PECAM-1), an immunoreceptor tyrosine-based inhibitory motif containing receptor, plays diverse and apparently contradictory roles in regulating the response of platelets to stimuli; inhibiting platelet response to immunoreceptor tyrosine-based activation motif and G protein-coupled receptor signalling ...
Chris I, Jones, Leonardo A, Moraes, Jonathan M, Gibbins   +2 more
openaire   +2 more sources

Curcumin inhibits activation induced by urban particulate material or titanium dioxide nanoparticles in primary human endothelial cells.

PLoS ONE, 2017
Curcumin has protective effects against toxic agents and shows preventive properties for various diseases. Particulate material with an aerodynamic diameter of ≤10 μm (PM10) and titanium dioxide nanoparticles (TiO2-NPs) induce endothelial dysfunction and
Angélica Montiel-Dávalos, Guadalupe Jazmin Silva Sánchez, Elizabeth Huerta-García, Cristhiam Rueda-Romero, Giovanny Soca Chafre, Irma B Mitre-Aguilar, Ernesto Alfaro-Moreno, José Pedraza-Chaverri, Rebeca López-Marure   +8 more
doaj   +1 more source

Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor. [PDF]

PLoS ONE, 2013
The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine.
Colin F Greineder, Ann-Marie Chacko, Sergei Zaytsev, Blaine J Zern, Ronald Carnemolla, Elizabeth D Hood, Jingyan Han, Bi-Sen Ding, Charles T Esmon, Vladimir R Muzykantov   +9 more
doaj   +1 more source

Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.

Journal of Immunology, 1999
Platelet/endothelial cell adhesion molecule-1 (PECAM-1; CD31), a member of the Ig superfamily, is expressed strongly at endothelial cell-cell junctions, on platelets, and on most leukocytes.
G. Duncan, D. Andrew, H. Takimoto, H. Takimoto, S. Kaufman, Hiroki Yoshida, Hiroki Yoshida, J. Spellberg, J. D. L. Pompa, A. Elia, A. Wakeham, Barbara Karan-Tamir, William A. Muller, G. Senaldi, M. Zukowski, Tak W. Mak, Tak W. Mak   +16 more
semanticscholar   +1 more source

Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression [PDF]

Proceedings of the National Academy of Sciences, 2010
Most patients who die from cancer succumb to treatment-refractory advanced metastatic progression. Although the early stages of tumor metastasis result in the formation of clinically silent micrometastatic foci, its later stages primarily reflect the progressive, organ-destructive growth of already advanced metastases.
Horace, DeLisser, Yong, Liu, Pierre-Yves, Desprez, Ann, Thor, Paraskevei, Briasouli, Chakrapong, Handumrongkul, Jonathon, Wilfong, Garret, Yount, Mehdi, Nosrati, Sylvia, Fong, Emma, Shtivelman, Melane, Fehrenbach, Gaoyuan, Cao, Dan H, Moore, Shruti, Nayak, Shruti, Nyack, Denny, Liggitt, Mohammed, Kashani-Sabet, Robert, Debs   +18 more
openaire   +2 more sources

Platelets and galectins [PDF]

, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source

Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]

, 1999
The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Amatruda TT, Bednar MM, Bellosta S, Buttrum SM, Buyon JP, Calara F, Calderon TM, Diacovo TG, Giroux LM, Jukema JW, Kim JA, Kimura M, Laufs U, Laws KH, Lehr H-A, Marcus AJ, Notabartolo A, Olstrowsky L, Pons F, Ruf A, Smalley DM, Stragliotto E, Sugiyama S, Weber C, Weber C, Weber C, Yeagle PL, Yeo EL, Yue TL   +28 more
core   +1 more source

Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass [PDF]

, 1999
Objectives: The investigation centers on whether there is a reperfusion-induced specific cardiac inflammatory reaction after bypass surgery. Background: Cardiopulmonary bypass (CPB) leads to systemic inflammation.
Becker, Bernhard F., Hartl, Heinz, Hähnel, Christoph, Massoudy, Parwis, Meisner, Hans, Zahler, Stefan   +5 more
core   +1 more source

Examining the role of insulin in the regulation of cardiovascular health [PDF]

, 2013
A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core   +1 more source