Results 101 to 110 of about 5,714,223 (293)

Antiplatelet Activity, P2Y1 and P2Y12 Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P1,P4-dithio-P2,P3-chloromethylenetetraphosphate [PDF]

, 2014
Background: Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation.
Frelinger, Andrew L. III, Yanachkov, Ivan B., Yanachkova, Milka, Barnard, Marc R., Chang, Hung, Dix, Edward J., Wright, George E., Frelinger, Andrew, Michelson, Alan D., Li, YouFu, Michelson, Alan   +10 more
core   +1 more source

Tofacitinib does not affect platelet function or coagulation in patients with ulcerative colitis

Frontiers in Immunology
BackgroundTofacitinib is a Janus kinase inhibitor used to treat inflammatory diseases, including rheumatoid arthritis and ulcerative colitis (UC). Previous studies have reported an increased risk of thromboembolic events in patients with rheumatoid ...
Fabio Suarez-Trujillo, Paula J. Martínez, Irene Soleto, Mar Meijón, Ana Kerguelen, Mar Orts, Antonio Planas, Natalia Acedo, Guillermo Chacón-Calvo, Ana Garre, Elena Moreno-Lopez, Nora Butta, María Chaparro, Montse Baldán-Martín, Javier P. Gisbert   +14 more
doaj   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Dissociation of glycoprotein IIb/IIIa antagonists from platelets does not result in fibrinogen binding or platelet aggregation

, 2008
BACKGROUND: The primary mechanism of action of glycoprotein (GP) IIb/IIIa antagonists is inhibition of the final common pathway of platelet aggregation: fibrinogen binding to the GP IIb/IIIa complex.
Frelinger, Andrew L. III, Barnard, Marc R., Furman, Mark I., Krueger, Lori A., Michelson, Alan D.   +4 more
core   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Sixty years of research into ancestry differences in platelet function

Platelets
Studies investigating the role of differential platelet function across various ancestry groups have been ongoing since at least the middle twentieth century. Consistently identified trends include differential frequency of CD36 deficiencies, variability
Jillian Teichman, Andrew D. Johnson
doaj   +1 more source

Relationship between monocyte‐platelet aggregation and endothelial function in middle‐aged and elderly adults

Physiological Reports, 2017
Low‐grade inflammation, endothelial dysfunction, and platelet hyper‐reactivity to agonists are associated with an increased risk of cardiovascular events.
Andrew Haynes, Matthew D. Linden, Elisa Robey, Louise H. Naylor, Kay L. Cox, Nicola T. Lautenschlager, Daniel J. Green   +6 more
doaj   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

Prognostic Value of Platelet Aggregation Function in Patients with laryngeal Carcinoma

, 2023
Minghua Li,1,* Jiawei Gui,1,* Hao Wang,2 Jun An,3 Ruoqing Wu,1 Xiaotong Liu,1 Bo Wu,1 Hui Xiao1 1Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, People’s Republic of
Liu X, An J, Xiao H, Wu R, Wu B, Gui J, Wang H, Li M   +7 more
core