Results 111 to 120 of about 1,059,321 (361)

Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding [PDF]

, 2022
Background: A significant challenge is faced for the genetic diagnosis of inherited platelet disorders in which candidate genetic variants can be found in more than 100 bleeding, thrombotic, and platelet disorder genes, especially within families in ...
Alamelu, J, Alikhan, R, Allsup, D, Astwood, E, Austin, S, Barnes, M, Basey, L, Bevan,, D, Bignell, P, Biss, T, Bolton Maggs, P, Camp, D, Chang, C, Chapman, O, Clark, J, Collins, P, Curry,, N, Daly, ME, Dattani, R, Davies, K, Dwenger, E, Edmead,, C, Elliot, K, Evans, G, Fareh, M, Fenwick, J, Fletcher, A, Foros, M, Foulkes, M, Fratter, C, Giangrande, P, Gissen, P, Gladstone, K, Gooding,, R, Graham,, C, Grainger, J, Green, P, Greenway, A, Grimley, GDC, Hanley, J, Harrison, P, Hay, C, Hupston, H, James, B, Keeling, D, Kesteven, P, Khan, AO, Khan, N, Kightley,, M, Kirwan, J, Knaggs, K, Lachmann, R, Lai-Wah, C, Lawson, N, Lester, W, Lokare, A, Longmuir, K, Lordkipanidze, M, Lowe, G, Makris, M, Mann, P, Mansell, D, Marshall, D, Marshall, K, Martlew, V, Morgan, N, Morgan, NV, Motwani, J, Mumford, AD, Mundell, SJ, Murphy, E, Myers, B, Nagapachetty, K, Nyatanga, P, Pavord, S, Payne, J, Percy, C, Pike, G, Pike,, A, Pope, M, Poulter, NS, Preston, S, Rayment, R, Rebecca Morris, AG, Rose, P, Rourke, AO, Smith, CW, Spencer, C, Stapley, RJ, Stokley, S, Talks, K, Thachil, J, Thomas, A, Toh, CH, Trower, L, Vowles, J, Watson, S, Will, A, Williams, M, Woods,, P   +99 more
core  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Skin calcium deposits in primary familial brain calcification: A novel potential biomarker

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Primary Familial Brain Calcification (PFBC) is a rare neurodegenerative disorder characterized by small vessel calcifications in the basal ganglia. PFBC is caused by pathogenic variants in different genes and its physiopathology is still largely unknown. Skin vascular calcifications have been detected in single PFBC cases, suggesting
Aron Emmi, Giulia Bonato, Aleksandar Tushevski, Cinzia Bertolin, Francesco Cavallieri, Andrea Porzionato, Angelo Antonini, Leonardo Salviati, Miryam Carecchio   +8 more
wiley   +1 more source

Inhibition of agonist-induced platelet aggregation by magnesium sulfate warrants its use as an alternative in vitro anticoagulant in pseudothrombocytopenia

Platelets, 2020
MgSO4 is effective in preventing spontaneous in vitro platelet agglutination in anticoagulant-induced pseudothrombocytopenia (PTCP). In order to learn more about its potential as an in vitro anticoagulant, platelets from MgSO4-anticoagulated blood were ...
Steffen Mannuß, Peter Schuff-Werner, Katrin Dreißiger, Christine Burstein   +3 more
doaj   +1 more source

Developing a computational model of blood platelets with fluid dynamics applications [PDF]

arXiv, 2012
This paper worked towards modeling blood platelets. Blood platelets, also known as thrombocytes, play a key role in blood clotting which is a vital human function. Furthermore, the role of these entities in strokes, myocardial infarctions, and coronary artery disease add to the importance of blood platelets.
arxiv  

Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure. [PDF]

, 2017
Evidence-based guidelines recommend exercise therapy for patients with chronic heart failure (CHF). Such patients have increased atherothrombotic risk. Exercise can transiently increase platelet activation and reactivity and decrease vascular function in
Andrew Haynes, Andrew Maiorana, Daniel J. Green, Ellen A. Dawson, Kazunori Nosaka, Lauren C. Chasland, Lawrence H. Dembo, Lip GY, Louise H. Naylor, Matthew D. Linden, Peake J   +10 more
core   +1 more source

ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective We performed a pilot screen to assess the utility of the NULISA™ (Nucleic‐acid‐Linked Immuno‐Sandwich Assay) platform in the identification of amyotrophic lateral sclerosis (ALS) biomarkers. Methods Plasma from 86 individuals (48 ALS, 18 asymptomatic C9orf72 repeat expansion carriers (AsymC9), and 20 healthy controls) was analyzed ...
Eleanor V. Thomas, Changee Han, Woo Jae Kim, Seneshaw Asress, Yingjie Li, Jennifer A. Taylor, Marla Gearing, Christina N. Fournier, Zachary T. McEachin, Nicholas T. Seyfried, Jonathan D. Glass   +10 more
wiley   +1 more source

Clinical Trial Readiness in Limb Girdle Muscular Dystrophy R1 (LGMDR1): A GRASP Consortium Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying functional measures that are both valid and reliable in the limb girdle muscular dystrophy (LGMD) population is critical for quantifying the level of functional impairment related to disease progression in order to establish clinical trial readiness in the context of anticipated therapeutic trials.
Stephanie M. Hunn, Lindsay N. Alfano, Aileen Jones, Amanda Butler, Linda P. Lowes, Megan A. Iammarino, Natalie F. Reash, Lindsay Pietruszewski, Sandhya Sasidharan, Melissa Currence, Jeffrey M. Statland, Talia Strahler, Robert Will, Matthew Wicklund, Stacy Dixon, Renee Augsburger, Tahseen Mozaffar, Katie M. Laubscher, Shelley R. H. Mockler, Katherine D. Mathews, Nikia Stinson, Doris G. Leung, Molly M. Stark, Rebecca A. Horton, Peter B. Kang, Meredith K. James, Amanda Clause, Conrad C. Weihl, Nicholas E. Johnson, GRASP‐LGMD Consortium   +29 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Counting Platelets: a Novel Image Analysis Algorithm for Detecting and Counting Platelet Adhesion on an Assay Pattern [PDF]

, 2019
Changes in platelet function is a major complication in patients with cardiovascular disease. The authors have previously designed a portable, easy to use, low cost biochip for monitoring of anti-platelet therapy in cardiovascular disease patients [1 ...
Berry, Damon, Courtney, Jane, Gilmartin, Niamh, Lee, Thomas   +3 more
core   +1 more source