Results 61 to 70 of about 633,370 (307)

Evaluation of platelet activation parameters as quality markers for the stored platelets [PDF]

Journal of Medical Biochemistry, 2007
In order to investigate the potential use of platelets activation parameters as routine quality control indicators during liquid storage, 27 PC-BC units were kept at 22 oC for up to 5 days.
Subota Vesna, Vučetić Dušan, Balint Bela, Mijušković Zoran, Vojvodić Danilo, Pejović Janko, Mandić-Radić Slavka   +6 more
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Identification of 22 novel mutations in patients with Glanzmann's thrombasthenia [PDF]

, 2008
Glanzmann's thrombasthenia (GT) is an autosomal recessive inherited platelet function defect that characterized by reduction in, or absence of, platelet aggregation in response to multiple physiologic agonists. GT is characterized by normal platelet
Abdul Ethayathulla, Birendra Yadav, Firdos Ahmad, Meganathan Kannan, Rajive Kumar, Renu Saxena, Ved Choudhry   +6 more
core   +1 more source

Impact of pneumatic tube vs. bicycle courier transport on platelet aggregation: influence of sex and diabetes

Frontiers in Medicine
AimPneumatic tube (PT) transport can impact platelet function, often altering platelet aggregation. Consequently, manual transport is frequently recommended to mitigate preanalytical effects on platelet function tests.
Anna Hohneck, Anna Hohneck, Elisabeth Kliemank, Elisabeth Kliemank, Simon Bach, Simon Bach, Sebastian Brings, Sebastian Brings, Lukas Seebauer, Lukas Seebauer, Mani Roshan, Mani Roshan, Zoltan Kender, Zoltan Kender, Stefan Kopf, Norbert Frey, Norbert Frey, Markus Zorn, Markus Zorn, Stefan M. Woerner, Stefan M. Woerner, Thomas Fleming, Thomas Fleming, Julia Szendroedi, Julia Szendroedi   +24 more
doaj   +1 more source

The interaction between preoperative platelet count and function and its relationship with postoperative bleeding in cardiac surgery

Platelets, 2017
Platelet function tests (PFTs) before cardiac surgery are predictive of postoperative bleeding and can guide a correct timing of surgery in patients under P2Y12 inhibitors. Thrombocytopenia affects PFT and may determine postoperative bleeding.
Marco Ranucci, Ekaterina Baryshnikova
doaj   +1 more source

Low-dose and standard-dose ticagrelor compared with clopidogrel in patients with acute coronary syndromes: A cohort study from china

Frontiers in Cardiovascular Medicine, 2022
PurposePrevious trials have demonstrated that ticagrelor was superior to clopidogrel in acute coronary syndrome (ACS) patients. However, several recent studies showed that ticagrelor was associated with a significantly higher risk of bleeding compared ...
Wenxing Peng, Yunnan Zhang, Yunnan Zhang, Yang Lin   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The Effect of Oscimum Sanctum to the Thrombocytes Number on Mice [PDF]

, 2016
Oscimum sanctum is herbal that was spread widely in Indonesia. Oscimum sanctum contains abundant of substances. One of the functions on Oscimum sanctum was anti-thrombocytes effect. This effect is associated with platelet function as a mechanical plug in
Astuti, Y. (Yoni), Wijayanti, R. (Rum)
core  

Lipolysis generates platelet dysfunction after in vivo heparin administration [PDF]

, 2002
Heparin, when administered to patients undergoing operations using cardiopulmonary bypass, induces plasma changes that gradually impair platelet macroaggregation, but heparinization of whole blood in vitro does not have this effect.
Belcher, P.R., Caslake, M.J., Chaudhry, M.A., Day, S., Muriithi, E.W., Wheatley, D.J.   +5 more
core   +1 more source

Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile

Frontiers in Cardiovascular Medicine, 2022
BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li, Li Li, Mark Roest, Yaqiu Sang, Yaqiu Sang, Jasper A. Remijn, Rob Fijnheer, Karel Smit, Dana Huskens, Dana Huskens, Jun Wan, Jun Wan, Bas de Laat, Bas de Laat, Joke Konings, Joke Konings   +15 more
doaj   +1 more source