Results 101 to 110 of about 116,983 (327)

New trends in the study of podoplanin as a cell morphological regulator

Japanese Dental Science Review, 2010
Podoplanin is a mucin-type glycoprotein firstly identified in podocytes, which is homologous to the type I alveolar cell specific T1α-2 antigen and to the oncofetal antigen M2A recognized by the D2-40 antibody. Podoplanin possesses a platelet aggregation-
Yoshihiko Sawa
doaj   +1 more source

Enhanced Hemocompatibility via Bivalirudin and Bicarbonate as Alternative to Heparin in a Catheter‐Based Axial‐Flow System

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Cardiovascular therapeutic devices typically require systemic heparin due to underlying thrombotic risk. The Impella axial flow system further relies on internal perfusion with either a heparin‐containing or sodium bicarbonate purge solution during operation.
Kaitlyn R. Ammann, Christine E. Outridge, Tiana Silver, Sami Muslmani, Jun Ding, Vladimir Gilman, Scott Corbett, Marvin J. Slepian   +7 more
wiley   +1 more source

Cultured human endothelial cells synthesize a plasma membrane protein complex immunologically related to the platelet glycoprotein IIb/IIIa complex [PDF]

, 1986
O. C. Leeksma, J Zandbergen-Spaargaren, JC Giltay, JA van Mourik   +3 more
openalex   +3 more sources

Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

Journal of Hematology & Oncology, 2019
Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane.
Jiansong Huang, Xia Li, Xiaofeng Shi, Mark Zhu, Jinghan Wang, Shujuan Huang, Xin Huang, Huafeng Wang, Ling Li, Huan Deng, Yulan Zhou, Jianhua Mao, Zhangbiao Long, Zhixin Ma, Wenle Ye, Jiajia Pan, Xiaodong Xi, Jie Jin   +17 more
doaj   +1 more source

Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins

Journal of Cell Biology, 1990
Treatment of platelets with thrombin was shown previously to induce rapid changes in tyrosine phosphorylation of several platelet proteins. In this report, we demonstrate that a variety of agonists which induce platelet aggregation also stimulate ...
A. Golden, J. Brugge, S. Shattil
semanticscholar   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia.

Journal of Clinical Investigation, 1986
An antiplatelet monoclonal antibody, PMI-1, reacts with glycoproteins (GP) GPIIb, free GPIIb, and the GPIIb-IIIa complex. This antibody binds to 40,900 sites per platelet, with a Kd = 0.95 microM, and its binding is inhibited by the presence of magnesium
M. Ginsberg, Alton L. Lightsey, T. J. Kunicki, A. Kaufmann, G. Marguerie, E. Plow   +5 more
semanticscholar   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Platelet receptors and signaling in the dynamics of thrombus formation

Haematologica, 2009
Hemostasis and pathological thrombus formation are dynamic processes that require a co-ordinated series of events involving platelet membrane receptors, bidirectional intracellular signals, and release of platelet proteins and inflammatory substances ...
José Rivera, María Luisa Lozano, Leyre Navarro-Núñez, Vicente Vicente   +3 more
doaj   +1 more source

Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery. [PDF]

, 1986
James N. George, E.B. Pickett, S Saucerman, Rodger P. McEver, Thomas J. Kunicki, Nicolas Kieffer, Peter J. Newman   +6 more
openalex   +1 more source