Results 111 to 120 of about 116,983 (327)
Food Frontiers, EarlyView.PDIA4 is significantly upregulated in response to nutrient overload in pancreatic β‐cells, resulting in aberrant ROS production, β‐cell failure, and diabetes. PDIA4 facilitates cancer development by inhibiting caspase‐mediatedcell death in cancer and promoting VEGF‐mediated protumoral immunity andangiogenesis in the tumor microenvironment, highlighting
Yi‐San Lee +4 more
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Revista Brasileira de Reumatologia, 2004 A esclerose sistêmica (ES) é uma doença sistêmica caracterizada por microangiopatia, exuberante atividade do fibroblasto e anormalidades imunológicas. A faceta microangiopática é responsável pela maioria das complicações com potencial mortalidade.
Paulo Sergio Massabki +2 more
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International Journal of Cancer, EarlyView.Abstract Liquid biopsy can revolutionize cancer patient management as repeated sampling allows real‐time monitoring of disease progression and response to treatment. The circulating transcriptome represents a rich source of potential cancer biomarkers, including coding and non‐coding RNAs.
Mengqian Li +7 more
wiley +1 more source
PLoS ONE, 2019 BackgroundFlow cytometric platelet activation has emerged as an alternative diagnostic test for inherited platelet disorders. It is, however, labor intensive and few studies have directly compared the performance of flow cytometric platelet activation ...
Kristoffer Navred +6 more
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Engineering Efferocytosis for Bone Regeneration
Macromolecular Bioscience, EarlyView.The repair of bone tissue in acute and chronic injuries is a significant long‐standing clinical challenge. Biomaterials‐based interventions are well‐positioned to interrogate mechanisms of efferocytosis due to their ability to provide support and guide cellular activity.
Jacob Miszuk, Linna Zhong, Hongli Sun
wiley +1 more source
Recent Advances in Injectable Hydrogel Biotherapeutics for Regenerative Dental Medicine
Macromolecular Bioscience, EarlyView.This review analyses multifunctional injectable hydrogels, natural or synthetic, physically or chemically crosslinked, that deliver exosomes, stem cells, and other bioactive cues to inflamed or damaged oral tissues. We discuss their immunomodulatory, antimicrobial, angiogenic, and osteogenic capacities, highlighting advances that enable regenerative ...
Renan Dal‐Fabbro +6 more
wiley +1 more source
International Journal of Nanomedicine, 2023 Fengshi Li,1,* Zhihua Rong,1,* Tianqi Chen,2 Peng Wang,1 Xiao Di,1 Leng Ni,1 Changwei Liu1 1Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing ...
Li F +6 more
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Macromolecular Bioscience, EarlyView.The study investigates how four ECM‐mimicking biomaterials—fibrin, fibronectin, and non‐crosslinked or crosslinked gelatin—affect different types of human endothelial cells. Cell viability, morphology, and angiogenic marker expression are evaluated. Results reveal substrate‐dependent effects on cell behavior and emphasize the importance of selecting ...
Jernej Vajda +5 more
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Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis
Med Research, EarlyView.The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang +7 more
wiley +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2013 Background Antiplatelet aggregation treatment has become a regular treatment of ischemic stroke. The affirmation of antiplatelet therapy is mainly derived from patients with clinical use, which can not provide the laboratory indexes for evaluation of a ...
Zhen ZHAO +5 more
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