British Journal of Pharmacology, EarlyView.Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti +10 more
wiley +1 more source
Platelet enumeration in dense aggregates [PDF]
arXivIdentifying and counting blood components such as red blood cells, various types of white blood cells, and platelets is a critical task for healthcare practitioners. Deep learning approaches, particularly convolutional neural networks (CNNs) using supervised learning strategies, have shown considerable success for such tasks.
arxiv
Human vascular endothelial cells express a membrane protein complex immunochemically indistinguishable from the platelet VLA-2 (glycoprotein Ia-IIa) complex [PDF]
, 1989 JC Giltay +4 more
openalex +1 more source
Role of the RAB27/SYTL Axis in Tumor Microenvironment Construction
Cancer Science, EarlyView.This review focuses on the role of the RAB27/SYTL axis in various cancer types associated with tumor microenvironment modifications. The importance of this pathway and the potential therapeutic strategies targeting vesicle production for the treatment of cancer are also discussed.
Miwa Tanaka, Takuro Nakamura
wiley +1 more source
Effect of calcium on the stability of the platelet membrane glycoprotein IIb-IIIa complex.
, 1985 L F Brass +3 more
openalex +1 more source
Isolation and structural characterization of the polypeptide subunits of membrane glycoprotein IIb-IIIa from human platelets [PDF]
, 1982 RP McEver, JU Baenziger, PW Majerus
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Association of Platelet Membrane Glycoprotein HPA-2a/b, GP VI T13254C, and GP Ibα VNTR Polymorphisms with Risk of Coronary Artery Disease: A Meta-Analysis. [PDF]
Biomed Res Int, 2017 Ni W, He J, Wang H, Liu T.
europepmc +1 more source
Platelet membrane topography: colocalization of thrombospondin and fibrinogen with the glycoprotein IIb-IIIa complex [PDF]
, 1985 AS Asch, LL Leung, MJ Polley, RL Nachman
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Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases
Cell Proliferation, EarlyView.Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei +5 more
wiley +1 more source