The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing. [PDF]
, 1989 Peter J. Newman +2 more
openalex +1 more source
Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility
Advanced Therapeutics, Volume 8, Issue 10, October 2025.This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam +5 more
wiley +1 more source
A Novel Role for Platelet-Endothelial Crosstalk in Pulmonary Hypertension. [PDF]
Am J Respir Cell Mol BiolHu L, Chen F.
europepmc +1 more source
Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib. [PDF]
, 1985 Joyce E. Fox
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Advanced Science, Volume 12, Issue 39, October 20, 2025.During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang +8 more
wiley +1 more source
Nanoparticles Functionalized with Polymer Brushes for Gene Delivery
Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.The engineering of the next generation gene delivery vectors requires the precise control of the architecture and physicochemical interactions controlling the transport, targeting, uptake, and release of nucleic acid materials to targeted cells. Polymer brush‐functionalized nanomaterials offer unprecedented control over such design and properties, and ...
Carlos E. Neri‐Cruz, Julien E. Gautrot
wiley +1 more source
ApoC3 Attenuates Platelet Activation Through GPIIb/IIIa Receptor Interaction. [PDF]
CellsHolzer M +4 more
europepmc +1 more source
Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa. [PDF]
, 1986 Peter J. Newman +3 more
openalex +1 more source
Emerging Strategies for Platelet‐Modified Nanoparticles in Targeted Tumor Therapy
Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.This review highlights innovative strategies using platelet‐modified nanoparticles to target tumors more precisely. By mimicking platelet functions, these biomimetic carriers improve tumor homing, enhance drug delivery, and reduce immune clearance.
Chunyu Bai +5 more
wiley +1 more source