Results 171 to 180 of about 116,983 (327)

Biomechanical platelet activation: diseases that require a new class of antiplatelet therapeutics. [PDF]

Am J Physiol Cell Physiol
Gupta R, Alkhalfan F, Wheeler J, Cameron SJ.   +3 more
europepmc   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

Promucetin, a new C-type lectin-like protein modulates coagulation by activating platelets via GPIb. [PDF]

J Venom Anim Toxins Incl Trop Dis
Yu XQ, Zhang QY, Zhou ST, Lu QY, Sun QY.
europepmc   +1 more source

Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cγ2 regulation in platelets [PDF]

, 2002
Peter Wonerow, Achim Obergfell, Jonathan I. Wilde, Régis Bobe, Naoki Asazuma, Tomáš Brdička, Albrecht Leo, Burkhart Schraven, Václav Hořejšı́, Sanford J. Shattil, Steve P. Watson   +10 more
openalex   +1 more source

Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor.

Proceedings of the National Academy of Sciences of the United States of America, 1991
Jerry Ware, J. Dent, Hiroyuki Azuma, Mitsuhiko Sugimoto, P. A. Kyrle, Akira YOSHIOKAt, Zaverio M. RuggeriT, Roon   +7 more
semanticscholar   +1 more source

Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer Therapeutics

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Immune checkpoints in tumor immunotherapy. Ligand binding to the receptor inhibits immune cell function, promotes tumor cell immune escape, and suppresses the immune response. The pathways of action are VISTA‐IGSF11, TIM‐3‐Ceacam1, CD47‐SIRPα, CTLA‐4‐CD80/CD86, PD‐L1‐PD‐1, MHC‐1‐LILRB, and CD24 ‐ Siglec ‐10. There are also other immune checkpoints such
Han Sun, Dan Huang, Huiling Zhang, Mingyuan Dong, Simiao Wang, Man Sun, Jiayi Liu, Yiqi Wang, Xiaojie Qu, Xuefeng Li, Zhaogang Yang   +10 more
wiley   +1 more source

Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure. [PDF]

Int J Mol Sci
Pokrovskaya ID, Ball KK, Webb MW, Joshi S, Rhee SW, Ware J, Storrie B.   +6 more
europepmc   +1 more source

Constitutive and functional association of the platelet collagen receptor glycoprotein VI–Fc receptor γ-chain complex with membrane rafts [PDF]

, 2002
Yasuharu Ezumi, Kumi Kodama, Takashi Uchiyama, Hiroshi Takayama   +3 more
openalex   +1 more source

Primary Progressive Multiple Sclerosis: New Therapeutic Approaches

Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.
Primary progressive MS affects 10%–15% of MS patients, causing irreversible neurological impairment. Drugs like ocrelizumab show promise, while high‐dose biotin, simvastatin, and coenzyme Q10 are under investigation. Gene therapy and stem cell treatments also show potential.
Morteza Rajabi, Sajjad Shafaeibajestan, Sevda Asadpour, Ghazal Alyari, Niloofar Taei, Moein Kohkalani, Ramin Raoufinia, Hamed Afarande, Ehsan Saburi   +8 more
wiley   +1 more source

Automated Quantitative Immunofluorescence Microscopy Approach for Diagnosis of Hereditary Thrombopathies: A Proof of Concept Using Bernard-Soulier Syndrome and Glanzmann Thrombasthenia. [PDF]

Genes (Basel)
Loos K, Al-Rifai R, Ohlenforst S, Klein C, Oldenburg J, Pavlova A, Pezeshkpoor B.   +6 more
europepmc   +1 more source