Results 11 to 20 of about 83,070 (313)

Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue. [PDF]

PLoS Pathogens, 2019
Thrombocytopenia and platelet dysfunction are commonly observed in patients with dengue virus (DENV) infection and may contribute to complications such as bleeding and plasma leakage.
Silvita Fitri Riswari, Rahajeng N Tunjungputri, Vesla Kullaya, Fadel M Garishah, Gloria S R Utari, Nur Farhanah, Gijs J Overheul, Bachti Alisjahbana, M Hussein Gasem, Rolf T Urbanus, Philip G de Groot, Dirk J Lefeber, Ronald P van Rij, Andre van der Ven, Quirijn de Mast   +14 more
doaj   +1 more source

Stimulation of platelet production: the new treatment approach to chronic immune thrombocytopenic purpura

Онкогематология, 2022
Chronic immune thrombocytopenic purpura (ITP) is one of the most frequent immune hematological disorders in which development the leading part is played by the antibodies directed against a narrow spectrum of platelet antigens.
A. A. Maschan, A. G. Rumyantsev
doaj   +1 more source

Investigation of interaction of human platelet membrane components with anticoagulant drugs Abciximab and Eptifibatide.

Folia Histochemica et Cytobiologica, 2011
Abciximab (Abci) and eptifibatide (Epti) are antiaggregate drugs which may reduce thrombotic complications in acute coronary syndromes. The aim of this work was the investigation of the interaction between the phospholipid-GPIIb/IIIa glycoprotein complex
Anna Sankiewicz, Ewa Gorodkiewicz, Zbigniew A Figaszewski   +2 more
doaj   +1 more source

Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them

Journal of Interventional Cardiology, 2021
Aim. To predict platelet accumulation around stent struts in the presence or absence of tissue defects around them. Methods. Computer simulations were performed using virtual platelets implementing the function of the three membrane proteins ...
Yota Kawamura, Noriko Tamura, Shinichi Goto, Shinya Goto   +3 more
doaj   +1 more source

Molecular study of sticky platelet syndrome using exome sequencing

Revista de la Facultad de Medicina, 2021
Introduction: Sticky platelet syndrome (SPS) is a prothrombotic condition characterized by increased platelet aggregation that causes arterial and venous thrombosis.
Jaime José Pérez-Niño, Gisela Barros-García, María Fernanda Garcés, Jorge Eduardo Caminos, María Brion, Eduardo Humberto Beltrán-Dussán   +5 more
doaj   +1 more source

Association of Platelet Desialylation and Circulating Follicular Helper T Cells in Patients With Thrombocytopenia

Frontiers in Immunology, 2022
Thrombocytopenia is a multifactorial condition that frequently involves concomitant defects in platelet production and clearance. The physiopathology of low platelet count in thrombocytopenia remains unclear. Sialylation on platelet membrane glycoprotein
Yuwen Chen, Liping Luo, Yongzhi Zheng, Qiaoyun Zheng, Na Zhang, Donghui Gan, Shimuye Kalayu Yirga, Zhenxing Lin, Qizhen Shi, Qizhen Shi, Lin Fu, Jianda Hu, Yingyu Chen   +12 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis

Biomedicines, 2023
Aging is a growing problem worldwide, and the prevalence and mortality of arterial and venous thromboembolism (VTE) are higher in the elderly than in the young population. To address this issue, various anticoagulants have been used. However, no evidence
Seung Hee Lee, Suyeon Cho, Jong Youl Lee, Jung Yeon Hong, Suji Kim, Myong-Ho Jeong, Won-Ho Kim   +6 more
doaj   +1 more source

Specific labelling of platelet membrane glycoproteins

FEBS Letters, 1980
The glycoproteins present on the platelet membrane are considered to be of great importance to platelet activities [ 1,2]. Few pathological platelet membrane glycoprotein abnormalities are known and ,usually they result in disturbance of aggregation.
Avner Rotman, Shoshana Linder, Victor Pribluda   +2 more
openaire   +3 more sources

Successful Management of Acute Catastrophic Juvenile Vaginal Bleeding in Glanzmann’s Thromboasthenia by Uterine Tamponade: A Case Report and Review of The Literature

Case Reports in Hematology, 2012
Glanzmann’s thromboasthenia (GT) is a rare platelet disorder, due to membrane defects involving glycoprotein GP IIb/IIIa complex. Symptoms appear in infancy with episodes of bruising, gingival bleeding, epistaxis, or at the time of menarche acute episode
Nazli Hossain, Tahir S. Shamsi, Adeel Feroz   +2 more
doaj   +1 more source