Results 11 to 20 of about 122,277 (348)
Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.
Journal of Biological Chemistry, 1985 Sanford J. Shattil +3 more
openalex +2 more sources
The basement membrane protein nidogen-1 supports platelet adhesion and activation
Platelets, 2021 The core structure of the extracellular basement membrane is made up of self-assembling networks of collagen and laminin which associate with each other through the bridging adapter proteins including the sulfated monomeric glycoprotein nidogen.
Hari Hara Sudhan Lakshmanan +12 more
doaj +1 more source
Frontiers in Pediatrics, 2022 Glanzmann thrombasthenia (GT) is a rare autosomal recessive platelet disorder due to a qualitative or quantitative anomaly of the platelet membrane glycoprotein GPIIb/IIIa. Its clinical manifestations include mild to severe bleeding.
Jian hua Li +9 more
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Haematologica, 2020 Platelet adhesion to the sub-endothelial matrix and damaged endothelium occurs through a multi-step process mediated in the initial phase by glycoprotein Ib binding to von Willebrand factor (vWF), which leads to the subsequent formation of a platelet ...
Simona Stivala +7 more
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Bio‐inspired functional coacervates
Aggregate, Volume 3, Issue 6, December 2022., 2022 Bio‐inspired functional coacervates have diverse functions. Natural and synthetic coacervates are a new class of materials that have great potential for various biomedical applications, including medical adhesives, drug delivery, and tissue engineering.
Shujun Chen, Qi Guo, Jing Yu
wiley +1 more source
The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation
Haematologica, 2020 Upon vascular injury, platelets adhere to von Willebrand Factor (VWF) via glycoprotein Ibα (GPIbα). GPIbα contains many glycans, capped by sialic acid. Sialic acid cleavage (desialylation) triggers clearance of platelets.
Dianne E. van der Wal +3 more
doaj +1 more source
Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia
Haematologica, 2022 Immune thrombocytopenia (ITP) is a bleeding disorder caused by dysregulated B- and T- cell functions, which lead to platelet destruction. A well-recognized mechanism of ITP pathogenesis involves anti-platelet and anti-megakaryocyte antibodies ...
Shiying Silvia Zheng +6 more
doaj +1 more source
Journal of Interventional Cardiology, 2021 Aim. To predict platelet accumulation around stent struts in the presence or absence of tissue defects around them. Methods. Computer simulations were performed using virtual platelets implementing the function of the three membrane proteins ...
Yota Kawamura +3 more
doaj +1 more source
Онкогематология, 2022 Chronic immune thrombocytopenic purpura (ITP) is one of the most frequent immune hematological disorders in which development the leading part is played by the antibodies directed against a narrow spectrum of platelet antigens.
A. A. Maschan, A. G. Rumyantsev
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Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue. [PDF]
PLoS Pathogens, 2019 Thrombocytopenia and platelet dysfunction are commonly observed in patients with dengue virus (DENV) infection and may contribute to complications such as bleeding and plasma leakage.
Silvita Fitri Riswari +14 more
doaj +1 more source