Results 231 to 240 of about 83,070 (313)

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

The FEBS Journal, Volume 292, Issue 19, Page 4979-4991, October 2025.
Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie, Rebecca Rowan, Dessi Malinova, Lisa Crawford   +3 more
wiley   +1 more source

Spleen Tyrosine Kinase Inhibition Mitigates Hemin-Induced Thromboinflammation in an Organ-Specific Manner in Sickle Cell Mice. [PDF]

Arterioscler Thromb Vasc Biol
El-Awaisi J, Perrella G, Mayor N, Tinkova V, Cleary SJ, Grygielska B, Watson SP, Dimitrov JD, Brill A, Hassan E, Nicolson PLR, Kavanagh D, Kalia N, Rayes J.   +13 more
europepmc   +1 more source

Silent Dangers in Elderly Pharmacotherapy: The Interplay of Polypharmacy, Multimorbidity, and Drug Interactions

Journal of Evaluation in Clinical Practice, Volume 31, Issue 7, October 2025.
ABSTRACT Background Pharmacological therapy in older persons is inherently complex due to the interplay of age‐related physiological changes, multimorbidity, and polypharmacy. These factors increase the vulnerability of elderly patients to drug interactions and adverse drug reactions.
N. N. Ngcobo
wiley   +1 more source

Acute Life-Threatening Glycoprotein IIb/IIIa Inhibitor-Induced Thrombocytopenia Following Percutaneous Coronary Intervention (PCI): A Case Report and Review of the Literature. [PDF]

Cureus
Souman B, Wyant C, Parekh Z, Shokoohi C, Valina A.   +4 more
europepmc   +1 more source

The Roles and Clinical Significance of Major Hepatic‐Derived Metabolites in Hepatocellular Carcinoma

Journal of Gastroenterology and Hepatology, Volume 40, Issue 10, Page 2435-2448, October 2025.
ABSTRACT Hepatocellular carcinoma (HCC) is increasingly recognized as a metabolically orchestrated malignancy, in which hepatic‐derived metabolites function not only as byproducts of liver physiology but also as active modulators of tumor biology.
Rui Sun, Xiaoru Wang, Jiayi Ma, Yuying Cai, Lei Li, Shanshan Wang   +5 more
wiley   +1 more source

Advancements in nanomedicine for modulating ischemic cardiomyopathy therapy. [PDF]

Mater Today Bio
Ren X, Wang Y, Yang J, Zhu M, Zhang L, Li L.   +5 more
europepmc   +1 more source

A Scoping Review of Pathogenesis, Current Treatments, and Novel Approaches for Vitiligo

Journal of Cosmetic Dermatology, Volume 24, Issue 10, October 2025.
ABSTRACT Background Vitiligo is a chronic skin disorder characterized by loss of melanocytes, causing depigmentation and psychological distress. Its pathogenesis is complex and multifactorial, involving genetic predisposition, autoimmune, oxidative stress, and neurogenic mechanisms.
Nusaibah Sallehuddin, Nur Izzah Md Fadilah, Mh Busra Fauzi, Manira Maarof   +3 more
wiley   +1 more source

Role of glycoproteins in hepatic lipid metabolism: emerging diagnostic markers and therapeutic targets. [PDF]

PeerJ
Lan B, Huang S, Luo J, Shi P, Qiang Z.
europepmc   +1 more source

Autoantibodies and Inflammation in Schizophrenia

Psychiatry and Clinical Neurosciences, Volume 79, Issue 10, Page 611-618, October 2025.
The potential role of autoantibodies in the etiology of schizophrenia is a key research focus because growing evidence suggests an association between immune dysfunction and psychotic disorders. This hypothesis is supported by findings indicating immune‐related abnormalities in patients with schizophrenia, including chronic inflammation and genetic ...
Hiroki Shiwaku
wiley   +1 more source