Results 231 to 240 of about 131,155 (303)

Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface

open access: yesAdvanced Science, Volume 13, Issue 2, 9 January 2026.
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu   +12 more
wiley   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino   +21 more
wiley   +1 more source

Single‐Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics

open access: yesAdvanced Science, Volume 13, Issue 5, 27 January 2026.
A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li   +13 more
wiley   +1 more source

Novel Bioresorbable Bone Wax for Potentiated Hemostasis and Osteogenesis

open access: yesAdvanced Science, Volume 13, Issue 2, 9 January 2026.
The synthesized bioresorbable bone wax material for hemostasis and osteogenesis. The preparation process of the novel resorbable bone wax and its mechanism of accelerating coagulation and promoting osteoregeneration through blood cell aggregation. Abstract Orthopedic surgery faces dual challenges of uncontrolled bleeding and poor bone regeneration at ...
Longbao Feng   +10 more
wiley   +1 more source

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The PSEN1E280A mutation causes autosomal dominant Alzheimer's disease (ADAD) with predictable onset, enabling presymptomatic studies. Extracellular vesicles (EVs) are emerging biomarkers of cognitive decline, but their role in early ADAD is unclear.
Lina Pineda‐Lopez   +14 more
wiley   +1 more source

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