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Membrane Glycoproteins in Cryopreserved Platelets
Vox Sanguinis, 1994AbstractAlthough platelets stored by cryopreservation are effective in hemostasis, they acquire a number of functional defects during storage and preparation for transfusion. In addition to known acquired defects such as defective aggregation, decreased resistance to hypotonic shock, and disc‐spherocyte transformation, we have shown that cryopreserved ...
C. Afflerbach +3 more
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Platelet Aggregation By Membrane Glycoprotein I [PDF]
Thrombosis and Haemostasis, 1981 It has been recently shown that platelet membrane components, particularly glycoproteins, have a lectin activity, thus mediating an aggregation of platelets. To obtain further evidences for a crucial role of glycoproteins in an aggregation mechanism,we have investigated the possibility that membrane glycoprotein can directly induce an aggregation of ...
Y. Ikeda +10 more
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Platelet membrane glycoproteins
Thrombosis Research, 1996Inherited giant platelet disorders (IGPD) are a heterogeneous group of rare diseases characterized by thrombocytopenia, large platelets and variable bleeding symptoms. Glycoprotein (GP) expression on platelet surface in these conditions is poorly characterized. We have investigated the expression of constitutively expressed platelet membrane GP and the
Miguel Lozano +5 more
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Platelet Membrane Glycoproteins
2017Platelets are small anucleate blood cells that are produced in the bone marrow from the cytoplasm of megakaryocytes. Circulating platelets are essential for primary hemostasis and also involved in pathological thrombosis. For the platelet hemostatic functions, platelet surface membrane glycoproteins are crucial to form platelet-subendothelial matrix ...
Yoshiaki Tomiyama, Hisashi Kato
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New polymorphism of platelet membrane glycoproteins
Nature, 1977THE surface of the human blood platelet is rich in carbohydrate and at least four glycoprotein components have been resolved by gel electrophoresis of isolated platelet plasma membranes1. Two platelet disease states are characterised by a diminution or absence of certain of these glycoproteins2–5: in the case of Bernard-Soulier disease, glycoprotein I (
R. B. Bolin, G. A. Jamieson, T. Okumura
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Thrombin Interaction With Platelet Membrane Glycoprotein Ib [PDF]
Seminars in Thrombosis and Hemostasis, 1996 Platelet activation by low doses of thrombin allows the amplification thrombin formation and thereby plays an important role in the development of thrombi. Although thrombin-induced platelet activation is elicited via the cleavage of its specific receptor (TR), platelet membrane glycoprotein Ib (GPIb) is required for responses to low concentrations of ...
Marie-Christine Bouton +3 more
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Polymorphisms of Platelet Membrane Glycoproteins
2009Platelet glycoproteins (GPs) act as membrane receptors. Functions of GPs were well studied in GPIa/IIa (integrin α2β1), GPIb/IX/V, GPIIb/IIIa (integrin αIIbβ3), and GPVI. Each GP has a different role in the processes of physiological hemostasis and thrombus formation, such as platelet adhesion to the subendothelial matrix, firm adhesion with subsequent
Mitsuru Murata +2 more
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Thrombosis and Thrombolysis: Platelet Membrane Glycoproteins
Heart, Lung and Circulation, 2007Over the last quarter of a century, therapy for acute coronary syndromes has rapidly evolved. The major causative factor for acute coronary syndromes, particularly acute myocardial infarction, is now recognised to be coronary thrombosis and therapies using thrombolytic agents to dissolve thrombus or percutaneous coronary interventions (angioplasty and ...
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The Membrane Glycoproteins: Adhesion and Aggregation of Platelets [PDF]
, 1985 Though the membrane of platelets, together with that of erythrocytes, is one of the most studied from a biochemical and functional point of view, that which we know about it is only a minimal part of what remains to be learned. This situation is largely due to the fact that platelets are very difficult cells to study, since small differences in ...
Edoardo Ascari +3 more
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