Results 261 to 270 of about 83,070 (313)
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New polymorphism of platelet membrane glycoproteins
Nature, 1977THE surface of the human blood platelet is rich in carbohydrate and at least four glycoprotein components have been resolved by gel electrophoresis of isolated platelet plasma membranes1. Two platelet disease states are characterised by a diminution or absence of certain of these glycoproteins2–5: in the case of Bernard-Soulier disease, glycoprotein I (
R. B. Bolin, G. A. Jamieson, T. Okumura
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Thrombin Interaction With Platelet Membrane Glycoprotein Ib [PDF]
Seminars in Thrombosis and Hemostasis, 1996 Platelet activation by low doses of thrombin allows the amplification thrombin formation and thereby plays an important role in the development of thrombi. Although thrombin-induced platelet activation is elicited via the cleavage of its specific receptor (TR), platelet membrane glycoprotein Ib (GPIb) is required for responses to low concentrations of ...
Marie-Christine Bouton +3 more
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Polymorphisms of Platelet Membrane Glycoproteins
2009Platelet glycoproteins (GPs) act as membrane receptors. Functions of GPs were well studied in GPIa/IIa (integrin α2β1), GPIb/IX/V, GPIIb/IIIa (integrin αIIbβ3), and GPVI. Each GP has a different role in the processes of physiological hemostasis and thrombus formation, such as platelet adhesion to the subendothelial matrix, firm adhesion with subsequent
Mitsuru Murata +2 more
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Thrombosis and Thrombolysis: Platelet Membrane Glycoproteins
Heart, Lung and Circulation, 2007Over the last quarter of a century, therapy for acute coronary syndromes has rapidly evolved. The major causative factor for acute coronary syndromes, particularly acute myocardial infarction, is now recognised to be coronary thrombosis and therapies using thrombolytic agents to dissolve thrombus or percutaneous coronary interventions (angioplasty and ...
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The Membrane Glycoproteins: Adhesion and Aggregation of Platelets [PDF]
, 1985 Though the membrane of platelets, together with that of erythrocytes, is one of the most studied from a biochemical and functional point of view, that which we know about it is only a minimal part of what remains to be learned. This situation is largely due to the fact that platelets are very difficult cells to study, since small differences in ...
Edoardo Ascari +3 more
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The Clinical Significance of Platelet Membrane Glycoproteins
Hematology/Oncology Clinics of North America, 1990To mediate their hemostatic functions, platelets must adhere to exposed vascular subendothelium and then aggregate. A variety of membrane glycoprotein receptors for adhesive ligands are present on platelets that promote adhesion and aggregation. Analysis of congenital disorders of platelet glycoproteins has been instrumental in clarifying our knowledge
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Further Characterization Of Platelet Membrane Glycoproteins
Thrombosis and Haemostasis, 1981The binding of 125I-labelled lectins to major and minor platelet glycoproteins (GP) and their subunits has been investigated. Human platelets were isolated, washed, solubilized in sodium dodecyl sulphate (SDS) under non-reducing conditions and separated on 5, 7.5 and 10 % non-reduced/reduced 2-D polyacrylamide gels.
E F Lüscher +9 more
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Thrombin interaction with platelet membrane glycoprotein Ibα [PDF]
Trends in Molecular Medicine, 2003 The interaction of thrombin with platelet glycoprotein Ibalpha (GPIb alpha) is required for optimal platelet activation. The crystal structures of platelet GPIb alpha bound to thrombin reported by Dumas et al. and Celikel et al. both reveal the simultaneous interaction of GPIb alpha with thrombin exosites I and II but differ markedly regarding how the ...
Marie-Christine Bouton +3 more
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Platelet Membrane Glycoproteins: Functions in Cellular Interactions
Annual Review of Cell Biology, 1990The understanding of the structure and function of platelet membrane glycoproteins has been facilitated by studies showing that they belong to larger gene families of cell surface receptors involved in cellular interactions. In some instances (e.g. GP IIb-IIIa and GP Ib-IX) the study of the platelet proteins has served as a prototype for relatively ...
N Kieffer, D R Phillips
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Studies on human and bovine platelet membrane glycoproteins
International Journal of Biochemistry, 1979Abstract 1. 1. We have re-evaluated the number of platelet membrane glycoproteins with use of sodium dodecyl sulfate—polyacrylamide gel electrophoresis and two highly sensitive detection techniques. 2. 2. The first involves incorporation of the fluorophore dansyi hydrazine into the carbohydrate moiety after post-electrophoresis periodate ...
Milton E. Noelken, John F. Mcmaster
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