Results 261 to 270 of about 116,983 (327)

Ristocetin-dependent reconstitution of binding of von Willebrand factor to purified human platelet membrane glycoprotein Ib-IX complex.

Biochemistry, 1988
Whether the human platelet membrane glycoprotein (GP) Ib-IX complex is the receptor for ristocetin-dependent binding of von Willebrand factor (vWF) has been examined by reconstitution with the purified components using a solid-phase bead assay.
M C Berndt, X. Du, W. Booth
semanticscholar   +1 more source

Platelet membrane glycoproteins

Thrombosis Research, 1996
Inherited giant platelet disorders (IGPD) are a heterogeneous group of rare diseases characterized by thrombocytopenia, large platelets and variable bleeding symptoms. Glycoprotein (GP) expression on platelet surface in these conditions is poorly characterized. We have investigated the expression of constitutively expressed platelet membrane GP and the
Miguel Lozano, Antonio Ordinas, Nuria Pujol-Moix, Silvia Perez-Pujol, Maribel Diaz-Ricart, Gines Escolar   +5 more
openaire   +4 more sources

New polymorphism of platelet membrane glycoproteins

Nature, 1977
THE surface of the human blood platelet is rich in carbohydrate and at least four glycoprotein components have been resolved by gel electrophoresis of isolated platelet plasma membranes1. Two platelet disease states are characterised by a diminution or absence of certain of these glycoproteins2–5: in the case of Bernard-Soulier disease, glycoprotein I (
R. B. Bolin, G. A. Jamieson, T. Okumura
openaire   +3 more sources

Platelet Membrane Glycoproteins

2017
Platelets are small anucleate blood cells that are produced in the bone marrow from the cytoplasm of megakaryocytes. Circulating platelets are essential for primary hemostasis and also involved in pathological thrombosis. For the platelet hemostatic functions, platelet surface membrane glycoproteins are crucial to form platelet-subendothelial matrix ...
Yoshiaki Tomiyama, Hisashi Kato
openaire   +2 more sources

Structure and function of the von Willebrand factor A1 domain: analysis with monoclonal antibodies reveals distinct binding sites involved in recognition of the platelet membrane glycoprotein Ib-IX-V complex and ristocetin-dependent activation.

Blood, 2000
Binding of the adhesive glycoprotein, von Willebrand factor (vWf), to the platelet membrane glycoprotein (GP) Ib-IX-V complex initiates platelet adhesion and aggregation at high shear stress in hemostasis and thrombosis.
Mariagrazia De Luca, D. Facey, Emmanuel J. Favaloro, Mark Hertzberg, James C. Whisstock, Tracy McNally, Robert K. Andrews, Michael C. Berndt   +7 more
semanticscholar   +1 more source

Binding of a novel 50-kilodalton alboaggregin from Trimeresurus albolabris and related viper venom proteins to the platelet membrane glycoprotein Ib-IX-V complex. Effect on platelet aggregation and glycoprotein Ib-mediated platelet activation.

Biochemistry, 1996
Binding of the multimeric adhesive glycoprotein, von Willebrand Factor (vWF), to the platelet membrane glycoprotein (GP) Ib-IX-V complex mediates platelet adhesion and initiates signal transduction leading to platelet activation. Recently described viper
Robert K. Andrews, M. Kroll, C. Ward, J. Rose, R. Scarborough, A. Smith, José A López, M. Berndt   +7 more
semanticscholar   +1 more source

Thrombin Interaction With Platelet Membrane Glycoprotein Ib [PDF]

Seminars in Thrombosis and Hemostasis, 1996
Platelet activation by low doses of thrombin allows the amplification thrombin formation and thereby plays an important role in the development of thrombi. Although thrombin-induced platelet activation is elicited via the cleavage of its specific receptor (TR), platelet membrane glycoprotein Ib (GPIb) is required for responses to low concentrations of ...
Marie-Christine Bouton, Marie-Claude Guillin, Martine Jandrot-Perrus, François Lanza   +3 more
openaire   +2 more sources

Polymorphisms of platelet membrane glycoprotein Ib associated with arterial thrombotic disease.

Blood, 1998
Platelet membrane glycoprotein Ibalpha (GPIbalpha) is a major receptor for von Willebrand factor and thrombin, which plays a key role in the initial development of thrombi.
R. González-Conejero, M. Lozano, J. Rivera, J. Corral, Juan A. Iniesta, J. Moraleda, V. Vicente   +6 more
semanticscholar   +1 more source

Polymorphisms of Platelet Membrane Glycoproteins

2009
Platelet glycoproteins (GPs) act as membrane receptors. Functions of GPs were well studied in GPIa/IIa (integrin α2β1), GPIb/IX/V, GPIIb/IIIa (integrin αIIbβ3), and GPVI. Each GP has a different role in the processes of physiological hemostasis and thrombus formation, such as platelet adhesion to the subendothelial matrix, firm adhesion with subsequent
Mitsuru Murata, Yasuo Ikeda, Yumiko Matsubara   +2 more
openaire   +2 more sources

Blockade of platelet membrane glycoprotein Ib receptors delays intracoronary thrombogenesis, enhances thrombolysis, and delays coronary artery reocclusion in dogs.

Circulation, 1994
Von Willebrand factor and platelet membrane glycoprotein Ib receptors interact to mediate platelet adhesion and thrombogenesis in stenosed and endothelium-injured arteries.
S. Yao, J. Ober, L. Garfinkel, Y. Hagay, N. Ezov, J. J. Ferguson, H. Anderson, A. Panet, M. Gorecki, L. Buja   +9 more
semanticscholar   +1 more source