Results 71 to 80 of about 165,105 (313)

Permeability and conductivity of platelet-reinforced membranes and composites [PDF]

, 2001
We present large scale simulations of the diffusion constant $D$ of a random composite consisting of aligned platelets with aspect ratio $a/b>>1$ in a matrix (with diffusion constant $D_0$) and find that $D/D_0 = 1/(1+ c_1 x + c_2 x^2)$, where $x= a v_f/b$ and $v_f$ is the platelet volume fraction.
arxiv   +1 more source

Rupture Forces among Human Blood Platelets at different Degrees of Activation [PDF]

, 2020
Little is known about mechanics underlying the interaction among platelets during activation and aggregation. Although the strength of a blood thrombus has likely major biological importance, no previous study has measured directly the adhesion forces of single platelet-platelet interaction at different activation states.
arxiv   +1 more source

Isolation of Some Platelet Membrane Glycoproteins [PDF]

Thrombosis and Haemostasis, 1977
The platelet is surrounded by a pronounced glycocalix formed by carbohydrate moieties of the membrane glycoproteins. The number of glycoproteins of the outer platelet membrane is greater in number than had previously been reported : when solubilized membranes are analyzed by SDS-polyacrylamide gel electrophoresis the number of separated carbohydrate ...
C. S. P. Jenkins, A. Sturk, S. L. Pfueller, K.J. Clemetson, E.F. Lüscher   +4 more
openaire   +1 more source

Disparate effects of adhesion and degranulation of platelets on myocardial and coronary function in postischaemic hearts [PDF]

, 1998
Beside the major effect of acute thrombus formation, little is known about the interaction of platelets with the coronary endothelium in an ischaemia–reperfusion situation.
Alloatti, Altieri, Bünger, Capron, Chang, Coker, Conforti, Cook, D'Souza, Dauber, Dreyer, Gilbert, Goulielmos, Grover, Hicks, Hoshiga, Kowalski, Kupatt, Languino, Mannaionini, Mogford, Möbert, Rodgers, Rousseau, Rubboli, Rösen, Sheppeck, Sheridan, Sixma, Swerlick, Takiguchi, Wheatley, Yang, Yang, Yang, Zahler   +35 more
core   +1 more source

Association between fibrinogen receptor (Glycoprotein IIb) polymorphism and the risk of venous thromboembolism: a systematic review

Egyptian Journal of Medical Human Genetics, 2019
Background The fibrinogen receptor is an integrin on the platelet surface and is shaped from two types of glycoprotein (GP) subunits, GPIIb and GPIIIa. Membrane glycoprotein IIb/IIIa plays an important role in platelet function.
Zahra Rezaei Dezaki, Raihaneh Bagheri, Batoul Pourgheysari   +2 more
doaj   +1 more source

An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts

Scientific Reports, 2023
Receptor diffusion plays an essential role in cellular signalling via the plasma membrane microenvironment and receptor interactions, but the regulation is not well understood.
Chukiat Tantiwong, Joanne L. Dunster, Rachel Cavill, Michael G. Tomlinson, Christoph Wierling, Johan W. M. Heemskerk, Jonathan M. Gibbins   +6 more
doaj   +1 more source

Three-dimensional Multiscale Model of Deformable Platelets Adhesion to Vessel Wall in Blood Flow [PDF]

, 2013
When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation.
arxiv   +1 more source

Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating [PDF]

, 2018
In this study, we designed a novel drug-eluting coating for vascular implants consisting of a core coating of the anti-proliferative drug docetaxel (DTX) and a shell coating of the platelet glycoprotein IIb/IIIa receptor monoclonal antibody SZ-21.
A Arsiwala, A Bierhalz, A Tan, AW Heldman, B Almería, B O’brien, B O’Brien, C Stettler, CJ Pan, CJ Sweeney, CL Song, D Sun, DM Saylor, E Boersma, E Camenzind, ES Park, ES Thian, F Danhier, GY An, H Zhang, HG Wang, J Kanzer, J Riegger, J Yang, J Zhang, JB Slee, JJ Wykrzykowska, JM Lee, JV Natarajan, K Kolandaivelu, KH Bønaa, KS Lim, M Gawaz, M Zamani, M Zamani, MK Dong, MP Skinner, MT Ali, PS Douglas, PW Erruys, RH Müller, RK Aggarwal, RL Wilensky, S Freiberg, S Garg, S Hossfeld, S Jang, S Lee, S Mcginty, S Meng, S Puricel, S Yasuda, SJ Liu, T Inoue, T Nakano, TM Ko, U Baber, X Ma, X Wu, X Xi, Y Cao, YH Lee, Z Yang   +62 more
core   +1 more source

Mechanisms of the antiplatelet and analgesic effects of dextromethorphan and its metabolites

Tzu Chi Medical Journal, 2020
Objective: In the present study, we investigated the effects of dextromethorphan (DM) and its metabolites, including dextrorphan (LK2), 3-methoxymorphinan (LK3), and 3-hydroxymorphinan (LK4), on platelet aggregationin vitro and the inflammatory pain ...
Wen-Lin Su, Yu-Ya Weng, Wen-Hsin Huang, Hao-Ai Shui, Tz-Chong Chou   +4 more
doaj   +1 more source

IgG platelet antibodies in EDTA-dependent pseudothrombocytopenia bind to platelet membrane glycoprotein IIb.

American Journal of Clinical Pathology, 1998
EDTA-dependent pseudothrombocytopenia (PTCP) consists of an inappropriate low platelet count caused by autoantibodies present in the serum samples reacting with platelets only in EDTA-anticoagulated blood.
F. Fiorin, A. Steffan, P. Pradella, N. Bizzaro, Potenza Rocco, Vincenzo De Angelis   +5 more
semanticscholar   +1 more source