Results 81 to 90 of about 131,155 (303)

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx [PDF]

, 2008
A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and ...
Becker, Bernhard F., Chappell, Daniel, Conzen, Peter, Jacob, Matthias, Rehm, Markus, Stoeckelhuber, Mechthild, Welsch, Ulrich   +6 more
core   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα – 14-3-3ζ] association

Haematologica, 2012
Background Cold storage of platelets reduces bacterial growth and preserves their hemostatic properties better than current procedures do. However, storage at 0°C induces [14-3-3ζ-glycoprotein Ibα] association, 14-3-3ζ release from phospho-Bad, Bad ...
Dianne E. van der Wal, Eelo Gitz, Vivian X. Du, Kimberly S.L. Lo, Cornelis A. Koekman, Sabine Versteeg, Jan Willem N. Akkerman   +6 more
doaj   +1 more source

Synergistic effect of collagen and CXCL12 in the low doses on human platelet activation.

PLoS ONE, 2020
CXCL12, also known as stromal cell-derived factor-1, is a chemokine classified into CXC families, which exerts its function by binding to specific receptors called CXCR4 and CXCR7. Human platelets express CXCR4 and CXCR7 on the plasma membrane.
Daiki Nakashima, Takashi Onuma, Kumiko Tanabe, Yuko Kito, Kodai Uematsu, Daisuke Mizutani, Yukiko Enomoto, Masanori Tsujimoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Haruhiko Tokuda, Shinji Ogura, Toru Iwama, Osamu Kozawa, Hiroki Iida   +14 more
doaj   +1 more source

The complement binding-like domains of the murine homing receptor facilitate lectin activity. [PDF]

, 1991
The leukocyte homing receptor (HR), the endothelial leukocyte adhesion molecule, and gmp140/platelet activation-dependent granule membrane protein are members of a family of adhesion molecules, termed the lectin cell adhesion molecules (LEC-CAMS) which ...
Fennie, C, Geoffrey, J, Imai, Y, Lasky, LA, Rosen, SD, Singer, M, Watson, SR   +6 more
core  

Medication Complications in Extracorporeal Membrane Oxygenation. [PDF]

, 2017
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics.
Aebi, Ami G. Shah, Anderson, Arlt, Barr, Barthelemy, Beiderlinden, Bein, Bembea, Bhatt-Meht, Boucher, Brandi N. Thoma, Brown, Buck, Buscher, Chung, Dagan, Dagan, de Montmollin, De Rosa, DeGrado, Donadello, Donadello, Dzierba, Erstad, Esper, Eyler, Flordelis Lasierra, Glauber, Greenberg, Gélisse, Hadidi, Hertzog, Hraiech, Hynynen, Johnston, Kawada, Kim, Koster, Krueger, Lamarche, Latronico, Lemaitre, Levison, Malfertheiner, Mehta, Michelle Peahota, Moore, Mousavi, Mulla, Mulla, Muntean, Oliver, Paden, Park, Perkins, Peters, Pettignano, Phillips, Pieri, Potter, Preston, Protti, Ranucci, Riker, Roberts, Roos, Rosen, Ruiz, Rybak, Saini, Sanfilippo, Satyapriya, Schmith, Shekar, Shekar, Shekar, Shekar, Shekar, Sherwin, Sklar, Smith, Spriet, Staudacher, Strunk, Subramaniam, Szefner, Tellor, Trudzinski, Tulman, Turner, Veinstein, Vilay, Wagner, Walter K. Kraft, Welsch, Wen, Wildschut, Wu, Young   +99 more
core   +2 more sources

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Carcinoembryonic Antigen Gene Family [PDF]

, 1991
The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons.
Accili, Ahnen, Anderson, Arakawa, Arakawa, Audette, Aurivillius, Barnett, Barnett, Barnett, Barnett, Barnett, Barthels, Beatty, Beauchemin, Beauchemin, Beauchemin, Beidler, Benchimol, Berling, Berling, Bhattacharya-Chatterjee, Biggin, Bischof, Bischoff-Delaloye, Bohn, Bordes, Borjigin, Boucher, Boucher, Buchegger, Buchegger, Burtin, Börmer, Capecchi, Chakrabarty, Chakrabarty, Chan, Chan, Chandrasekaran, Chou, Chou, Chu, Cordon, Cournoyer, Cross, Cunningham, DeRobertis, Dustin, Edelman, Edwards, Egan, Fantini, Feizi, Fiebig, Freyer, Fritsch, Fritsche, Fritz Grunert, Gold, Gold, Goldenberg, Goldenberg, Greiner, Greiner, Grosveld, Grunert, Grunert, Guadagni, Hager, Hammarström, Haniford, Hansson, Hardman, Hass, Hefta, Hefta, Hefta, Hemperly, Higashide, Hinoda, Hinoda, Hinoda, Hostetter, Huang, Huitric, Hwang, Inazawa, Jean, John A. Thompson, Jones, Kamarck, Kasuga, Khan, Khan, Khan, Knapp, Kobata, Kodelja, Kolbinger, Kudo, Kupchik, Kuroki, Kuroki, Kuroki, Kuroki, Kuroki, Kuroki, Kuroki, Kurroki, Lai, Leon, Leslie, Leusch, Lewis, Lin, Lin, Lin, Lisanti, Losman, Mach, Margolis, Margolis, Martin, Matsuoka, McDonald, McLenachan, Monden, Mount, Nagata, Neumaier, Neumaier, Neumaier, Nichols, Niemann, Niemann, Niles, Novak-Hofer, Ocklind, Odin, Ogilvie, Oikawa, Oikawa, Oikawa, Oikawa, Oikawa, Paxton, Perkins, Perrotti, Pignatelli, Proudfoot, Ravetch, Ravetch, Rebstock, Rees-Jones, Rojas, Rooney, Rosen, Rosen, Rudert, Rudert, Ruoslahti, Sack, Salzer, Sato, Saunders, Schmid, Schonk, Schrewe, Schrewe, Schwarz, Schwarz, Sell, Sewell, Sharkey, Shively, Siepen, Slightom, Smale, Soeller, Staunton, Staunton, Streydio, Streydio, Streydio, Svenberg, Svenberg, Takami, Takeichi, Takeichi, Tatarinov, Tawaragi, Terry, Thomas, Thomas, Thompson, Thompson, Thompson, Thompson, Thompson, Tingström, Toribara, Toribara, Toth, Toth, Tran, Tsao, Tsujisaki, Tsujisaki, Tuan, Turbide, Van der Schoot, Van der Schoot, Von Kleist, Von Kleist, Von Kleist, Von Kleist, Vorličková, Wallner, Watanabe, Watanabe, Watt, Willcocks, Willcocks, Williams, Williams, Williams, Wolfgang Zimmermann, Yamaguchi, Yarden, Zheng, Zhou, Zimmermann, Zimmermann, Zimmermann, Zoubir, Öbrink   +236 more
core   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source