Results 181 to 190 of about 40,970 (289)

Molecular mechanism for platelet hyperreactivity in diabetes mellitus. [PDF]

J Diabetes Investig
Kaneto H.
europepmc   +1 more source

The role of protease-activated receptors (PARs) in the functioning of platelets and platelet-derived microparticles (PMPs). [PDF]

Front Mol Biosci
Jakobsche-Policht U, Bronowicka-Szydełko A, Adamiec R, Bednarska-Chabowska D, Mierzchała-Pasierb M, Lewandowski Ł, Gostomska-Pampuch K, Adamiec-Mroczek J, Rabczyński M, Kuźnik E, Lubieniecki P, Dróżdż O, Martynowicz H, Kwiecień A, Strzelecka M, Rudkiewicz D, Piersiak M, Ziomek M, Kondracki M, Galińska Z, Madziarska K.   +20 more
europepmc   +1 more source

T‐cell receptor–like chimeric antigen receptor T cells targeting mesothelin: A first‐in‐human dose‐escalation trial for platinum‐resistant advanced ovarian cancer

Cancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Ovarian cancer remains a formidable therapeutic challenge due to late diagnosis, high recurrence rates, and limited treatment options. Mesothelin (MSLN) is highly expressed in ovarian cancer, making it a promising target for immunotherapy.
Yiyang Shan, Bo Ding, Feng Ji, Hao Lin, Weiwei Shi, Enxiu Wang, Chen Wang, Yang Shen   +7 more
wiley   +1 more source

Role of glycoproteins in hepatic lipid metabolism: emerging diagnostic markers and therapeutic targets. [PDF]

PeerJ
Lan B, Huang S, Luo J, Shi P, Qiang Z.
europepmc   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Resveratrol as a Potential Platelet Inhibitor in Aspirin-Resistant Diabetic Patients-A Novel Therapeutic Strategy Targeting F₀F₁-ATP Synthase Inhibition. [PDF]

Life (Basel)
Panfoli I, Carlini L.
europepmc   +1 more source

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Astral-DIA proteomics and 4D label-free N-glycoproteomics of milk fat globule membrane proteins reveal distinct profiles between yak colostrum and mature milk. [PDF]

Food Chem X
Su D, Zhang X, An T, Wang X, Lin Y, Wang H, Yu P, Shi H.   +7 more
europepmc   +1 more source

A Human Model of Oligodendrocyte Development Shows MCL‐1 Influences Oligodendrocyte Morphogenesis

Glia, Volume 74, Issue 2, February 2026.
A unified model of oligodendrocyte differentiation from human embryonic stem cells revealed that MCL‐1 is critical for regulating the expression of oligodendrocyte‐related genes and the morphogenesis of myelinating oligodendrocytes. ABSTRACT Oligodendrocytes are the myelinating cells of the central nervous system.
Melanie Gil, Marina R. Hanna, Vivian Gama   +2 more
wiley   +1 more source

Sudden-Onset Severe Thrombocytopenia Secondary to Trimethoprim-Sulfamethoxazole. [PDF]

Cureus
Spadafora J, Spadafora P, Spadafora J, Starcke J, Spadafora PF.   +4 more
europepmc   +1 more source